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Genetic control of the kinetics of mouse spermatogenesis

Published online by Cambridge University Press:  14 April 2009

W. Robert Bruce ,
Rudolf Furrer ,
Robert B. Goldberg ,
Marvin L. Meistrich  and
Beatrice Mintz
W. Robert Bruce
Affiliation:
Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Canada
Rudolf Furrer
Affiliation:
Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Canada
Robert B. Goldberg
Affiliation:
Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Canada
Marvin L. Meistrich
Affiliation:
Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Canada
Beatrice Mintz
Affiliation:
Institute for Cancer Research, Fox Chase, Philadelphia, Pa. 19111, U.S.A.
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The kinetics of spermatogenesis in the mouse, and the possible genetic controls, have been investigated in different genotypes by means of the method of velocity sedimentation at unit gravity to separate testis cells and nuclei labelled with tritiated thymidine. The progression of the radioactivity through different sedimentation classes of cells provides a measure of their kinetics. The results demonstrate kinetic differences at the stage of spermatocyte differentiation between the C57BL/6 and AKR inbred strains of Mus musculus musculus and in randombred mice of the subspecies Mus m. molossinus. These kinetic differences are controlled by genetic factors which are not linked to the Y chromosome. The relevant autosomal alleles of C57BL/6 are dominant over those of AKR in F1 hybrids.

Type
Research Article
Information
Genetics Research , Volume 22 , Issue 2 , October 1973 , pp. 155 - 167
Copyright
Copyright © Cambridge University Press 1973

References

REFERENCES

Beatty, R. A. (1969). A genetic study of spermatozoan dimensions in mice selected for body weight. Indian Journal of Heredity 1, 2–21.Google Scholar
Chowdhury, A. W. & Steinberger, E. (1964). A quantitative study of the effect of heat on germinal epithelium of rat testis. American Journal of Anatomy 115, 509–524.CrossRefGoogle Scholar
Clermont, Y. (1972). Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal. Physiological Reviews 52, 198–236.CrossRefGoogle ScholarPubMed
Clermont, Y. & Harvey, S. C. (1965). Duration of the cycle of the seminiferous epithelium of normal, hypophysectomized and hypophysectomized-hormone treated albino rats. Endocrinology 76, 80–89.CrossRefGoogle ScholarPubMed
Clermont, Y. & Morgenthaler, H. (1955). Quantitative study of spermatogenesis in the hypophysectomized rat. Endocrinology 57, 369–382.CrossRefGoogle ScholarPubMed
Clermont, Y. & Trott, M. (1969). Duration of the cycle of the seminiferous epithelium in the mouse and hamster determined by means of3H-thymidine and radioautography. Fertility and Sterility 20, 805–817.CrossRefGoogle ScholarPubMed
Desclin, J. & Ortavant, R. (1963). Influence des hormones gonadotropes sur la durée des processes spermatogénétiques chez le rat. Annales de Biologie Animate de Biochemie et Bio-physique 3, 329–342.CrossRefGoogle Scholar
Falconer, D. S. (1963). Quantitative inheritance. In Methodology in Mammalian Genetics (ed. by Burdett, W. J.), p. 215. San Francisco: Holden Day.Google Scholar
Firlit, C. F. & Davis, J. R. (1965). Morphogenesis of the residual body of the mouse. Quarterly Journal of Microscopical Science 106, 93–98.Google Scholar
Go, V. L. W., Vernon, R. G. & Fritz, I. B. (1971). Studies on spermatogenesis in rats. III. Effects of hormonal treatment on differentiation kinetics of the spermatogenic cycle in regressed hypophysectomized rats. Canadian Journal of Biochemistry 49, 768–775.CrossRefGoogle Scholar
Krzanowska, H. (1969). Factor responsible for spermatozoan abnormality located on the Y chromosome in mice. Genetical Research 13, 17–24.CrossRefGoogle Scholar
Lam, D. M. K., Furrer, R. & Bruce, W. R. (1970). The separation, physical characterization and differentiation kinetics of spermatogonial cells of the mouse. Proceedings of the National Academy of Sciences of the United States of America 65, 192–199.CrossRefGoogle ScholarPubMed
Loir, M. & Wyrobek, A. (1972). Density separations of mouse spermatid nuclei. Experimental Cell Research 75, 261–265.CrossRefGoogle ScholarPubMed
Leblond, C. P. & Clermont, Y. (1952). Definition of the stages of the cycle of the seminiferous epithelium in the rat. Annals of the New York Academy of Sciences 55, 548–573.CrossRefGoogle ScholarPubMed
Meistrich, M. L. (1972). Separation of mouse spermatogenic cells by velocity sedimentation. Journal of Cellular Physiology 80, 299–312.CrossRefGoogle ScholarPubMed
Meistrich, M. L. & Eng, V. W. S. (1972). Separation of nuclei of mouse testis cells by sedimentation velocity. Experimental Cell Research 70, 237–242.CrossRefGoogle ScholarPubMed
Meistrich, M. L., Bruce, W. R. & Clermont, Y. (1973 a). Cellular composition of fractions of mouse testis cells following velocity sedimentation separation. Experimental Cell Research 79, 213–227.CrossRefGoogle ScholarPubMed
Meistrich, M. L., Eng, V. W. S. & Loir, M. (1973 b). Temperature effects on the kinetics of spermatogenesis in the mouse. Cell and Tissue Kinetics 6, 379–393.Google ScholarPubMed
Metcalf, D. (1960). Adrenal corticol function in high-and low-leukemia strains of mice. Cancer Research 20, 1347–1353.Google Scholar
Miller, R. G. & Phillips, R. A. (1969). Separation of cells by velocity sedimentation. Journal of Cellular Physiology 73, 191–202.CrossRefGoogle ScholarPubMed
Monesi, V. (1962). Autoradiographic study of DNA synthesis and the cell cycle in spermato-gonia and spermatocytes of mouse testis using tritiated thymidine. Journal of Cell Biology 14, 1–18.CrossRefGoogle ScholarPubMed
Oakberg, E. F. (1956 a). A description of spermatogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal. American Journal of Anatomy 99, 391–413.CrossRefGoogle ScholarPubMed
Oakberg, E. F. (1956 b). Duration of spermatogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium. American Journal of Anatomy 99, 507–515.CrossRefGoogle ScholarPubMed
Perey, B., Clermont, Y. & Leblond, C. P. (1961). The wave of the seminiferous epithelium in the rat. American Journal of Anatomy 108, 47–77.CrossRefGoogle Scholar
Roosen-Runge, E. C. (1962). The process of spermatogenesis in mammals. Biological Reviews 37, 343–377.CrossRefGoogle ScholarPubMed
Vitale-Calpe, R. & Burgos, M. H. (1970). The mechanism of spermiation in the hamster. II. The ultrastructural effects of coitus and LH administration. Journal of Ultrastructural Research 31, 394–406.CrossRefGoogle ScholarPubMed
Welshons, W. J. & Russell, L. B. (1959). The F-chromosome as the bearer of male determining factors in the mouse. Proceedings of the National Academy of Sciences of the United States of America 45, 560–566.CrossRefGoogle Scholar