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Genetic control of the kinetics of mouse spermatogenesis

Published online by Cambridge University Press:  14 April 2009

W. Robert Bruce ,
Rudolf Furrer ,
Robert B. Goldberg ,
Marvin L. Meistrich  and
Beatrice Mintz
W. Robert Bruce
Affiliation:
Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Canada
Rudolf Furrer
Affiliation:
Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Canada
Robert B. Goldberg
Affiliation:
Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Canada
Marvin L. Meistrich
Affiliation:
Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Canada
Beatrice Mintz
Affiliation:
Institute for Cancer Research, Fox Chase, Philadelphia, Pa. 19111, U.S.A.
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The kinetics of spermatogenesis in the mouse, and the possible genetic controls, have been investigated in different genotypes by means of the method of velocity sedimentation at unit gravity to separate testis cells and nuclei labelled with tritiated thymidine. The progression of the radioactivity through different sedimentation classes of cells provides a measure of their kinetics. The results demonstrate kinetic differences at the stage of spermatocyte differentiation between the C57BL/6 and AKR inbred strains of Mus musculus musculus and in randombred mice of the subspecies Mus m. molossinus. These kinetic differences are controlled by genetic factors which are not linked to the Y chromosome. The relevant autosomal alleles of C57BL/6 are dominant over those of AKR in F1 hybrids.

Type
Research Article
Information
Genetics Research , Volume 22 , Issue 2 , October 1973 , pp. 155 - 167
Copyright
Copyright © Cambridge University Press 1973

References

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