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The genetic control of antibody production. A study of isoimmune antibodies in cattle twins*

Published online by Cambridge University Press:  14 April 2009

J. Sellei  and
J. Redel
J. Sellei
Affiliation:
Department of Animal Breeding, Agricultural College of Sweden, Uppsala
J. Redel
Affiliation:
Department of Animal Breeding, Agricultural College of Sweden, Uppsala
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1. The antibody response was studied in twenty-five monozygous (MZ) and ten dizygous (DZ) pairs o f cattle twins, which were inoculated with red cells from one cattle donor carrying the M, V and U′ antigens. These red cell antigens are controlled by genes at three different loci. Most o f the recipients lacked two or all of these antigens. All had passed puberty at the onset of the experiment.

2. The antibody response against the three antigens differed markedly. Anti-U′ appeared on the average 11 days after the 1st injection and the maximum titre values were high. The V antibodies were produced at a slow rate, while anti-M was intermediate.

3. There was some influence of age on the rate and intensity of antibody production. Older animals gave a faster response and, with regard to anti-M, also higher titres.

4. Twins belonging to the same MZ pair usually produced v e r y similar antibody curves. However, there was at least one noticeable exception, which is given special consideration in the Discussion. The differences between MZ pairs accounted for a considerable portion of the variance in the different measures of antibody response and in most cases this portion remained significant also after the elimination of the influence o f age and sex. The DZ pairs were more variable.

5. The simultaneous response o f two or three antibodies in the same animal was studied. There was a significant positive association between antibody types which suggests the existence o f individual (probably genetic) differences in the general antibody-producing ability.

Type
Research Article
Information
Genetics Research , Volume 11 , Issue 3 , June 1968 , pp. 271 - 288
Copyright
Copyright © Cambridge University Press 1968

References

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