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Genetic analysis of some mutations causing resistance to tetracycline in Escherichia coli K12

Published online by Cambridge University Press:  14 April 2009

E. C. R. Reeve
E. C. R. Reeve
Affiliation:
Institute of Animal Genetics, Edinburgh 9
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Mutations in at least five different genetic loci cause some degree of resistance to Chloramphenicol, Tetracycline or both antibiotics in Escherichia coli K12. Two have been identified as chromosomal genes: cmlA near λ prophage and cmlB near pyrD. A third, giving mucoid antibiotic-resistant mutants, is probably capR (Ion) near lac. Another group of mucoid mutants gives marked increases in resistance to Tetracycline and in sensitivity to Puromycin; these mutants do not occur at capR. Although all the mutations have rather small effects on resistance level, the patterns of resistance to the three antibiotics appear to be characteristically different for mutations at different loci.

Type
Research Article
Information
Genetics Research , Volume 11 , Issue 3 , June 1968 , pp. 303 - 310
Copyright
Copyright © Cambridge University Press 1968

References

REFERENCES

Broda, P. (1967). The formation of Hfr strains of Escherichia coli K12. Genet. Res. 9, 35–48.CrossRefGoogle Scholar
Markovitz, A. & Baker, B. (1967). Suppression of radiation sensitivity and capsular poly-saccharide synthesis in Escherichia coli K12 by Ochre suppressors. J. Bact. 94, 388–395.CrossRefGoogle Scholar
Reeve, E. C. R. (1966). Characteristics of some single-step mutants to chloramphenicol resistance in Eschericria coli K12 and their interactions with R-factor genes. Genet. Res. 7, 281–286.CrossRefGoogle ScholarPubMed
Reeve, E. C. R. & Bishop, J. O. (1965). Variations in resistance to three antibiotics among some single-step mutants to Chloramphenicol resistance in a strain of Escherichia coli K12. Genet. Res. 6, 310–315.CrossRefGoogle Scholar
Reeve, E. C. R. & Suttie, D. R. (1968). Chromosomal location of a mutation causing chloramphenicol resistance in Escherichia coli K12. Genet. Res. 11, 97–104.CrossRefGoogle Scholar
Taylor, A. L. & Trotter, C. D. (1967). Revised linkage map of Escherichia coli. Bact. Rev. 31, 332–353.CrossRefGoogle ScholarPubMed