Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-23T12:45:07.528Z Has data issue: false hasContentIssue false

Genetic analysis of physiological homeostasis: glomerular filtration rate following saline loading in mice

Published online by Cambridge University Press:  14 April 2009

J. Stewart
Affiliation:
Department of Genetics, Milton Road, Cambridge, England
S. Mowbray
Affiliation:
Department of Genetics, Milton Road, Cambridge, England
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Saline loading caused an increase in glomerular filtration rate in RAP mice but not in CBA mice. On the basis of progeny testing of F 2 hybrids, backcrosses to CBA, and inbred lines derived from backcrosses to RAP, it was concluded that the difference between the strains RAP and CBA was probably largely accounted for by a single gene locus. The use of this gene in physiological investigations of the control of glomerular filtration rate is suggested.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1972

References

REFERENCES

Cannon, W. (1929). Organization for physiological homeostasis. Physiological Reviews 9, 399431.CrossRefGoogle Scholar
De Rouffignac, C. & Bonvalet, J. P. (1970). Variations in glomerular filtration-rate of single superficial and deep nephrons under various conditions of sodium intake in the rat. Pflugers Archiv, European Journal of Physiology 317, 141156.CrossRefGoogle Scholar
Haldane, J. B. S. (1955). The complete matrices for brother-sister and alternate parent-offspring mating involving one locus. Journal of Genetics 53, 315324.CrossRefGoogle Scholar
Stewart, J. (1969). Diuretic responses to electrolyte loads in four strains of mice. Comparative Biochemistry and Physiology 30, 977987.CrossRefGoogle ScholarPubMed
Stewart, J. (1970). Genetic variation in patterns of nephron function during natriuresis in mice. American Journal of Physiology 219, 865871.CrossRefGoogle ScholarPubMed
Stewart, J. (1971). Renal concentrating ability in mice: a model for the use of genetic variation in elucidating relationships between structure and function. Pflugers Archiv, European Journal of Physiology 327, 115.CrossRefGoogle Scholar
Thoday, J. M. (1953). Components of fitness. Symposium of the Society for Experimental Biology 7, 96113.Google Scholar
Thurau, K. (1969). The dependency of intrarenal distribution of single nephron filtration-rates on dietary salt intake (micropuncture studies). Proceedings of the Royal Society of Medicine 62, 11181122.CrossRefGoogle ScholarPubMed