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A gene triplet in the mouse*

Published online by Cambridge University Press:  14 April 2009

A. G. Searle  and
Gillian M. Truslove
A. G. Searle
Affiliation:
M.R.C. Radiobiology unit, Harwell, Berks.
Gillian M. Truslove
Affiliation:
M.R.C. Experimental Genetics Unit, University College London
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Mice heterozygous for rump-white (Rw) have white hair in lumbo-sacral and caudal regions, although the tail-tip is sometimes pigmented. The homozygote is lethal in utero. No recombination has been found between Rw and the very closely linked spotting genes patch (Ph) and the viable allele of W (Wv). The compounds between these genes are all viable and fertile, although individual homozygotes are either lethal (Ph, Rw) or sterile and anaemic (Wv). It is concluded that they are non-allelic, but form a gene triplet. Close linkage between a cluster of dominant spotting genes and an angora gene in mouse and rabbit provide evidence for homology of part of linkage group II in the rabbit and part of linkage group XVII in the mouse.

Type
Research Article
Information
Genetics Research , Volume 15 , Issue 2 , April 1970 , pp. 227 - 235
Copyright
Copyright © Cambridge University Press 1970

References

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