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The gene controlling the binding sites of Dolichos biflorus agglutinin, Dlb-1, is on chromosome 11 of the mouse

Published online by Cambridge University Press:  14 April 2009

H. G. Uiterdijk ,
B. A. J. Ponder ,
M. F. W. Festing ,
J. Hilgers ,
L. Skow  and
R. Van Nie
H. G. Uiterdijk
Affiliation:
Division of Tumor Biology, The Netherlands Cancer Institute Antoni van Leeuwenhoekhuis, Amsterdam, The Netherlands
B. A. J. Ponder
Affiliation:
Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, U.K.
M. F. W. Festing
Affiliation:
MRC Experimental Embryology and Teratology Unit, Carshalton, Surrey, U.K.
J. Hilgers
Affiliation:
Division of Tumor Biology, The Netherlands Cancer Institute Antoni van Leeuwenhoekhuis, Amsterdam, The Netherlands
L. Skow
Affiliation:
National Institute of Environmental Health Sciences, Research Triangle Park, N.C., U.S.A.
R. Van Nie
Affiliation:
Division of Tumor Biology, The Netherlands Cancer Institute Antoni van Leeuwenhoekhuis, Amsterdam, The Netherlands
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Summary

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A locus, Dlb-1, controlling the binding of the lectin from Dolichos biflorus to the intestinal epithelium and vascular endothelium of mice has been located on chromosome 11, 3.1 ± 1.4 centimorgans proximal to Rex, using recombinant inbred strains and conventional backcrosses with three-point linkage tests.

The two alleles so far discovered at this locus behave unusually. The Dlb-1a allele causes binding to the vascular endothelium but not to the intestinal epithelium while Dlb-1b induces the exact reciprocal binding pattern, and the heterozygote shows both patterns.

Type
Research Article
Information
Genetics Research , Volume 47 , Issue 2 , April 1986 , pp. 125 - 129
Copyright
Copyright © Cambridge University Press 1986

References

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