Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-23T01:26:06.044Z Has data issue: false hasContentIssue false
  • English
  • Français

Factors affecting the observed number of young resulting from adjacent-2 disjunction in mice carrying a translocation

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon  and
P. H. Glenister
Mary F. Lyon
Affiliation:
MRG Radiobiology Unit, Harwell, Didcot, OXON 0X11 0RD
P. H. Glenister
Affiliation:
MRG Radiobiology Unit, Harwell, Didcot, OXON 0X11 0RD
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The frequency of adjacent-2 disjunction in mice carrying the reciprocal translocation T(9; 17)138Ca was studied by mating together animals heterozygous for the translocation and carrying different recessive marker genes, using Tt for chromosome 17 and cwcw for chromosome 9. The proportion of marked young arising from adjacent-2 disjunction varied according to the markers carried in the two parents. When the female carried Tt the frequencies of marked young were always higher than when non-T females were used, and when Tt and cwcw were carried in the same parent there was a shortage of marked young obtaining both copies of the proximal region of chromosome 17 from the father. Both these effects were regarded as probably another example of the phenomenon discovered by Johnson, of inviability of young lacking a maternal homologue of a certain region of chromosome 17. There were other variations in frequency of marked young, among crosses using non-T females, which may have been due to differences in transmission ratio of male gametes carrying various t-haplotypes or to true variations in frequency of adjacent-2 disjunction.

Type
Research Article
Information
Genetics Research , Volume 29 , Issue 1 , February 1977 , pp. 83 - 92
Copyright
Copyright © Cambridge University Press 1977

References

REFERENCES

Bennett, D. (1975). The T-locus of the mouse. Cell 6, 441–454.CrossRefGoogle Scholar
Carter, T. C., Lyon, M. F. & Phillips, R. J. S. (1955). Gene-tagged chromosome translocations in eleven stocks of mice. Journal of Genetics 53, 154–166.CrossRefGoogle Scholar
Carter, T. C., Lyon, M. F. & Phillips, R. J. S. (1956). Further studies of eleven translocations in the mouse. Journal of Genetics 54, 462–473.CrossRefGoogle Scholar
Evans, E. P., Breckon, G. & Ford, C. E. (1964). An air-drying method for meiotic preparations from mammalian testes. Cytogenetics 3, 289–294.CrossRefGoogle ScholarPubMed
Forejt, J. (1972). Chiasmata and crossing-over in the male mouse (Mus musculus). Suppression of recombination and chiasma frequencies in the ninth linkage group. Folia biologica 18, 161–170.Google ScholarPubMed
Green, M. C. & Stimpfling, J. (1966). Private communication. Mouse News Letter 35, 32.Google Scholar
Johnson, D. R. (1974). Hairpintail: A case of post-reductional gene action in the mouse egg? Genetics 76, 795–805.CrossRefGoogle ScholarPubMed
Johnson, D. R. (1975). Further observations on the hairpintail (Thp) mutation in the mouse. Genetical Research 24, 207–213.CrossRefGoogle Scholar
Klein, J. & Klein, D. (1972). Position of the translocation break T(2;9)138Ca in linkage group IX of the mouse. Genetical Research 19, 177–179.CrossRefGoogle Scholar
Lyon, M. F. (1977). Private communication. Mouse News Letter 56.Google Scholar
Lyon, M. F., Butler, J. M. & Kemp, R. (1968). The position of the centromeres in linkage groups II and IX of the mouse. Genetical Research 11, 193–199.CrossRefGoogle ScholarPubMed
Lyon, M. F., Glenister, P. H. & Hawker, S. G. (1972). Do the H-2 and T-loci of the mouse have a function in the haploid phase of sperm? Nature 240, 152–153.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Meredith, R. (1964). The nature of t-alleles in the mouse: I. Heredity 19, 301–312.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Phillips, R. J. S. (1959). Crossing-over in mice heterozygous for t-alleles. Heredity 13, 23–32.CrossRefGoogle Scholar
Searle, A. G., Ford, C. E. & Beechey, C. V. (1971). Meiotic disjunction in mouse translocations and the determination of centromere position. Genetical Research 18, 215–235.CrossRefGoogle ScholarPubMed