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The expression of the gene asebia in the laboratory mouse: 3. Sebaceous glands

Published online by Cambridge University Press:  14 April 2009

Wendy J. Josefowicz  and
Margaret H. Hardy
Wendy J. Josefowicz
Affiliation:
Department of Biomedical Sciences, University of Guelph, Guelph, Canada NIG 2W2
Margaret H. Hardy
Affiliation:
Department of Biomedical Sciences, University of Guelph, Guelph, Canada NIG 2W2

Summary

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Contrary to what their name asebia implies, mice homozygous for the ab gene do possess actively secreting sebaceous glands which develop normally from the follicular outer root sheath, at 18 days post-conception. However, by the 20th day post-conception, these mice exhibit the abnormal sebaceous cytodifferentiation which remains typical of the asebic glands throughout life. Nests of outer root sheath cells below the sebaceous glands also undergo atypical sebaceous differentiation. The smooth membrane system and mitochondria, which appear to be responsible for the orderly accumulation of lipid droplets and sebum production in normal mice, become increasingly abnormal in asebic mice. Fewer lipid droplets form, the smooth endoplasmic reticulum becomes distorted and dilated, and the normal transformation of mitochondria does not occur. Atypical differentiation occurs randomly and ‘differentiated’ cells often degenerate within the asebic sebaceous glands. Of the larger specialized sebaceous-type glands studied, only the Meibomian glands are similarly affected by the asebia mutation, while the anal and preputial glands appear to undergo a more normal cytological differentiation. The abnormalities seen in the asebic sebaceous glands seem to be due to defective regulation of the synthetic or degenerative processes necessary for completion of normal sebum production. Both the defects of sebaceous glands and the unusual characteristics of the epidermis and hair follicles in asebic mice may be initiated by the abnormal underlying dermis or the apparently abnormal endocrine system.

Type
Research Article
Information
Genetics Research , Volume 31 , Issue 2 , April 1978 , pp. 157 - 166
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Bell, M. (1969). Crystalline inclusions in sebaceous glands of macaques. Journal of Cell Biology 43, 12a.Google Scholar
Billingham, R. E. & Silvers, W. K. (1967). Studies on the conservation of epidermal specificities of skin and certain mucosas in adult mammals. Journal of Experimental Medicine 125, 429–446.CrossRefGoogle ScholarPubMed
Bullough, W. S. & Laurence, E. B. (1970). Chalone control of mitotic activity in sebaceous glands. Cell and Tissue Kinetics 3, 291–300.Google ScholarPubMed
Cunha, G. R. (1972 a). Epithelio-mesenchymal interactions in primordial gland structures which become responsive to androgenic stimulation. Anatomical Record 172, 179–196.CrossRefGoogle ScholarPubMed
Cunha, G. R. (1972 b). Tissue interactions between epithelium and mesenchyme of urogenital and integumental origins. Anatomical Record 172, 529–542.CrossRefGoogle Scholar
Ebbesen, P. (1974). Aging increases susceptibility of mouse skin to DMBA carcinogenesis independent of general immune status. Science N.Y. 183, 217–218.CrossRefGoogle ScholarPubMed
Ebling, F. J. (1963). Hormonal control of sebaceous glands in experimental animals. In Advances in Biology of Skin, vol. IV. The sebaceous glands (ed. Montagna, W., Ellis, R. A. and Silver, A. F.), pp. 200–219. New York: Macmillan.Google Scholar
Ebling, F. J. (1967). The action of an anti-androgenic steriod 17α-methyl-β-Nortestosterone on sebum secretion in rats treated with testosterone. Journal of Endocrinology 38, 181–185.CrossRefGoogle Scholar
Ebling, F. J. (1973). Effects of cyproterone acetate and oestradiol on testosterone stimulated sebaceous activity in rats. Acta Endocrinologica 72, 361–365.Google Scholar
Ebling, F. J., Ebling, E. & Skinner, J. (1969 a). The influence of pituitary hormones on the response of the sebaceous glands of the male rat to testosterone. Journal of Endocrinology 45, 245–256.CrossRefGoogle ScholarPubMed
Ebling, F. J., Ebling, E. & Skinner, J. (1969 b). The influence of the pituitary on the response of the sebaceous and preputial glands of the rat to progesterone. Journal of Endocrinology 45, 257–263.CrossRefGoogle ScholarPubMed
Gates, A. H. & Karasek, M. A. (1965). Hereditary absence of sebaceous glands in the mouse. Science N.Y. 148, 1471–1473.CrossRefGoogle ScholarPubMed
Gomot, L. (1959). Contribution a l'étude du développement embryonnaire de la glande uropygienne chez le canard. Archives d'Anatomie Microscopique et de Morphologie Experimentale, Supplement 48, 63–141.Google Scholar
Gutierriz, M. & Aoki, A. (1973). Fine structure of gular gland of the free-tailed bat, Tadarida brasiliensis. Journal of Morphology 141, 293–305.CrossRefGoogle Scholar
Hamilton, E. (1974). Cell kinetics in the sebaceous glands of the mouse. I. The glands in resting skin. Cell and Tissue Kinetics 7, 389–398.Google ScholarPubMed
Hardy, M. H. (1949). The development of mouse hair in vitro with some observations of pigmentation. Journal of Anatomy 83, 364–384.Google ScholarPubMed
Hummel, K. P., Richardson, F. L. & Fekete, E. (1966). Anatomy. In Biology of the Laboratory Mouse (ed. Green, E. L.), pp. 247–308. New York: McGraw-Hill Book Co.Google Scholar
Josefowicz, W. J. (1975). The Development and Expression of the Asebia Mutation in Mice. M.Sc. Thesis, University of Guelph, Guelph, Canada.Google Scholar
Josefowicz, W. J. & Hardy, M. H. (1978 a). The expression of the gene asebia in the laboratory mouse. 1. Epidermis and dermis. Genetical Research.CrossRefGoogle Scholar
Josefowicz, W. J. & Hardy, M. H. (1978 b). The expression of the gene asebia in the laboratory mouse. 2. Hair follicles. Genetical Research.CrossRefGoogle Scholar
Montagna, W. & Parakkal, P. F. (1974). The Structure and Function of Skin, 3rd ed.New York, London: Academic Press.Google Scholar
Nay, T. (1972). Mouse News Letter 46, 40.Google Scholar
Nay, T. (1973). Personal communication.Google Scholar
Rogers, G. E. (1957). Electron microscopic observations on the structure of sebaceous glands. Experimental Cell Research 13, 517–520.CrossRefGoogle ScholarPubMed
Sengel, P. (1975). Morphogenesis of Skin. No. 3 in Development and Cell Biology Series. Cambridge: Cambridge University Press.Google Scholar