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Effects of selection for independent changes in two highly correlated body weight traits of mice*

Published online by Cambridge University Press:  14 April 2009

J. C. McCarthy  and
D. P. Doolittle
J. C. McCarthy
Affiliation:
Faculty of Agriculture, University College, Glasnevin, Dublin 9, Ireland and Purdue University, Lafayette, Indiana 47907, U.S.A.
D. P. Doolittle
Affiliation:
Faculty of Agriculture, University College, Glasnevin, Dublin 9, Ireland and Purdue University, Lafayette, Indiana 47907, U.S.A.
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Mice were selected for high and low body weight at 5 and at 10 weeks of age. Selection was performed (1) separately for each trait, and (2) for various combinations of the two traits, using (a) independent culling levels and (b) restricted indices. Two-way selection for each trait separately gave large responses and correlated responses. Selection by independent culling levels intended to increase 5-week weight while restricting change in 10-week weight gave no demonstrable response; selection by culling levels intended to decrease 5-week weight while restricting change in 10-week weight resulted in decreases in body weights at both ages. Index selection, intended to change weight at one age while holding that at the other age constant, was generally successful. Observed responses did not conform very well with predicted responses for either index or culling levels selection. The significance of these observations in regard to the problem of selection involving restriction of traits is discussed.

Type
Research Article
Information
Genetics Research , Volume 29 , Issue 2 , April 1977 , pp. 133 - 145
Copyright
Copyright © Cambridge University Press 1977

References

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