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The effects of Salmonella typhimurium on derepressed mutants of F-like factors

Published online by Cambridge University Press:  14 April 2009

N. D. F. Grindley ,
E. S. Anderson ,
H. R. Smith  and
June N. Grindley
N. D. F. Grindley
Affiliation:
Enteric Reference Laboratory, Public Health Laboratory Service, Colindale Avenue, London, N.W.9
E. S. Anderson
Affiliation:
Enteric Reference Laboratory, Public Health Laboratory Service, Colindale Avenue, London, N.W.9
H. R. Smith
Affiliation:
Enteric Reference Laboratory, Public Health Laboratory Service, Colindale Avenue, London, N.W.9
June N. Grindley
Affiliation:
Enteric Reference Laboratory, Public Health Laboratory Service, Colindale Avenue, London, N.W.9
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Derepressed mutants of F-like transfer factors, isolated by mutagenesis, were characterized as repressor-minus (i−) or operator-constitutive (oc). Mutants of the i− class are derepressed in K12 but repressed in Salmonella typhimurium. They are derepressed in S. typhimurium by a kanamycin resistance determinant carrying a locus der, described previously. Most oc mutants of F-like factors are derepressed in both K 12 and S. typhimurium. However, one mutant of F-lac was oc in K12 but was repressed in S. typhimurium. It was derepressed by der. Repression by S. typhimurium is different from that by fi+ factors, since der reverses the former but does not affect the latter. Possible interpretations of these findings are discussed.

Type
Short Paper
Information
Genetics Research , Volume 17 , Issue 1 , February 1971 , pp. 89 - 93
Copyright
Copyright © Cambridge University Press 1971

References

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