Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-20T07:40:39.818Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of selection on genetic variability: a simulation study

Published online by Cambridge University Press:  14 April 2009

M. G. Bulmer
M. G. Bulmer
Affiliation:
Department of Biomathematics, Pusey Street, Oxford
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Computer simulations have been done to study the effects of stabilizing and disruptive selection on a polygenic character. The results are reported in terms of three components of genetic variability which represent changes in gene frequencies, departures from Hardy–Weinberg equilibrium and linkage disequilibrium respectively. Under random mating the first and third components are the most important. The observed changes in gene frequencies are interpreted in the light of previous theoretical work on the stability of equilibria under selection. In addition, large and rapid changes in the genotypic variance result from the generation of linkage disequilibrium under selection; the observed changes are in good agreement with those predicted on theoretical grounds.

Type
Research Article
Information
Genetics Research , Volume 28 , Issue 2 , October 1976 , pp. 101 - 117
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

Bulmer, M. G. (1971 a). The stability of equilibria under selection. Heredity 27, 157–162.CrossRefGoogle ScholarPubMed
Bulmer, M. G. (1971 b). The effect of selection on genetic variability. American Naturalist 105, 201–211.CrossRefGoogle Scholar
Bulmer, M. G. (1974 a). Density-dependent selection and character displacement. American Naturalist 108, 45–58.CrossRefGoogle Scholar
Bulmer, M. G. (1974 b). Linkage disequilibrium and genetic variability. Genet. Res. 23, 281–289.CrossRefGoogle ScholarPubMed
Falconer, D. S. (1957). Selection for phenotypic intermediates in Drosophila. J. Genet. 55, 551–561.CrossRefGoogle Scholar
Falconer, D. S. (1960). Introduction to Quantitative Genetics. Edinburgh: Oliver and Boyd.Google Scholar
Hill, W. G. (1974). Disequilibrium among several linked neutral genes in finite populations. II. Variances and covariances of disequiibria. Theor. Pop. Biol. 6, 184–198.CrossRefGoogle Scholar
Hill, W. G. & Robertson, A. (1968). Linkage disequilibrium in finite populations. Theor. Appl. Genet. 38, 226–231.CrossRefGoogle ScholarPubMed
Roughgarden, J. (1972). Evolution of niche width. American Naturalist 106, 683–718.CrossRefGoogle Scholar
Slatkin, M. (1970). Selection and polygenic characters. Proc. Nat. Acad. Sci. 66, 87–93.CrossRefGoogle ScholarPubMed