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The effect of H-2 region and genetic background on hormone-induced ovulation rate, puberty, and follicular number in mice

Published online by Cambridge University Press:  14 April 2009

J. L. Spearow ,
R. P. Erickson ,
T. Edwards  and
L. Herbon
J. L. Spearow
Affiliation:
Reproductive Endocrinology Program, and Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA Department of Meat and Animal Science, University of Wisconsin, Madison, Wisconsin, USA
R. P. Erickson
Affiliation:
Department of Meat and Animal Science, University of Wisconsin, Madison, Wisconsin, USA
T. Edwards
Affiliation:
Reproductive Endocrinology Program, and Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
L. Herbon
Affiliation:
Reproductive Endocrinology Program, and Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
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We have examined the effects of major histocompatibility (H-2) haplotypes and genetic background (all loci other than the H-2 region) on hormone-induced ovulation rate in congenic strains of mice. In comparison with the H-2a haplotype, the H-2b haplotype increased hormone-induced ovulation rate 92% on the A/J (A) genetic background. However, H-2 haplotype did not affect hormone-induced ovulation rate on the C57BL/10J (C57) genetic background. The H-2b-linked gene(s) increased hormone-induced ovulation rate on the A/J genetic background largely by (1) enhancing the maturation of follicles in response to pregnant mare's serum gonadotrophin (PMSG) and (2) altering the stages of follicular development which can be induced to ovulate in response to human chorionic gonadotrophin (hCG). The observed effects of H-2 on hormone-induced ovulation rate were not explained by differences in the timing of puberty, the number of follicles present in untreated females, or the incidence of follicular atresia. The effect of genetic background on hormone-induced ovulation rate was much greater than was the effect of the H-2 region. We found that hormone-induced ovulation rate was five- to six-fold higher on the C57 genetic background than on the A genetic background. The C57 genetic background increased hormone-induced ovulation rate by (1) enhancing the induction of follicular maturation in response to gonadotropins and (2) by reducing the incidence of follicular atresia.

Type
Research Article
Information
Genetics Research , Volume 57 , Issue 1 , February 1991 , pp. 41 - 49
Copyright
Copyright © Cambridge University Press 1991

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