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Dosage dependent modifiers of white alleles in Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

Joy F. Sabl  and
James A. Birchler
Joy F. Sabl
Affiliation:
The Biological Laboratories, Harvard University, Cambridge, MA 02138
James A. Birchler*
Affiliation:
The Biological Laboratories, Harvard University, Cambridge, MA 02138
*
‡Corresponding author.
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Summary

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As part of a study to identify dosage-sensitive modifiers of the white eye colour locus and the retrotransposon, copia, a segmental aneuploid screen was conducted. It surveys the autosomal complement of the genome for dosage dependent modifiers of white, including ones effective upon retrotransposon insertion-induced alleles. Several regions were found which, when present as a segmental trisomy, affected one or more of the alleles tested in a strong and consistent fashion. Two of these regions have been identified as containing previously described modifiers, Darkener of-apricot and Inverse regulator-a. The remainder identify new white allele modifiers. Selected segmental monosomics were also tested where possible for regions exhibiting a trisomic effect. At least three regions were found to have a dosage-dependent effect in one, two and three copies.

Type
Research Article
Information
Genetics Research , Volume 62 , Issue 1 , August 1993 , pp. 15 - 22
Copyright
Copyright © Cambridge University Press 1993

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