Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-23T00:35:50.602Z Has data issue: false hasContentIssue false
  • English
  • Français

Distorter genes of the mouse t-complex impair male fertility when heterozygous

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon
Mary F. Lyon
Affiliation:
M.R.C. Radiobiology Unit, Chilton, Didcot, Oxon OX11 ORD, U.K.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Male mice heterozygous for two distorter genes, Tcd-1 and Tcd-2, of the mouse t-complex but homozygous wild type for the responder, were generated by crossing animals carrying the partial t-haplotypes th51 and th18 to inbred strains. The fertility of these males was then compared with that of their brothers carrying normal chromosome 17s. On three of the inbred backgrounds used, C3H/HeH, C57BL/6J and TFH/H, the th51th18 + / + + + males were significantly less fertile than their normal sibs. With the fourth inbred strain used, SM/JH, both types of male were nonnally fertile. This confirmed earlier preliminary findings that when both homologues of chromosome 17 carry wild-type alleles of the responder, heterozygosity for the distorter genes is sufficient to impair fertility, but the effect varies with genetic background. These results are consistent with the concept that both the transmission ratio distortion and the male sterility caused by the t-complex are due to harmful effects of the distorter genes on wild-type alleles of the responder.

Type
Research Article
Information
Genetics Research , Volume 49 , Issue 1 , February 1987 , pp. 57 - 60
Copyright
Copyright © Cambridge University Press 1987

References

Frischauf, A. M. (1985). The T/t complex of the mouse. Trends in Genetics 1, 100–103.Google Scholar
Hashimoto, Y., Suzuki, A., Yamakawa, T., Miyashita, N. & Moriwaki, K. (1983). Expression ofGMl and GD1a in mouse liver is linked to the H-2 complex on chromosome 17. Journal of Biochemistry 94, 2043–2048.Google Scholar
Klein, J., Figueroa, F. & David, C. S. (1983). H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17, 553–596.Google Scholar
Lewontin, R. C. (1962). Interdeme selection controlling a polymorphism in the house mouse. American Naturalist 96, 65–78.Google Scholar
Lewontin, R. C. (1968). The effect of differential viability on the population dynamics of t alleles in the house mouse. Evolution 22, 262–273.Google Scholar
Lewontin, R. C. & Dunn, L. C. (1960). The evolutionary dynamics of a polymorphism in the house mouse. Genetics 45, 705–722.Google Scholar
Lyon, M. F. (1984). Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37, 621–628.Google Scholar
Lyon, M. F. (1986). Male sterility of the mouse t-complex is due to homozygosity of the distorter genes. Cell 44, 357–363.Google Scholar
Olds-Clarke, P. & Peitz, B. (1985). Fertility of sperm from t/ + mice: evidence that + − bearing sperm are dysfunctional. Genetical Research 47, 49–52.Google Scholar
Peters, J., Swallow, D., Andrews, S. J. & Evans, L. (1981). A gene (Neu-1) on chromosome 17 of the mouse affects acid -glucosidase and codes for neuraminidase. Genetical Research 38, 47–55.CrossRefGoogle ScholarPubMed
Seitz, A. W. & Bennett, D. (1985). Transmission ratio distortion of t haplotypes is due to interactions between meiotic partners. Nature 313, 143–144.Google Scholar
Silver, L. M. (1985). Mouse t haplotypes. Annual Reviews of Genetics 19, 179–208.Google Scholar
Washburn, L. L. & Eicher, E. M. (1983). Sex reversal in XY mice caused by dominant mutation on chromosome 17. Nature 303, 338–340.Google Scholar
Willison, K. R., Dudley, K. & Potter, J. (1985). Molecular cloning and sequence analysis of a haploid expressed gene encoding t-complex polypeptide 1. Cell 44, 727–738.Google Scholar
Womack, J. E., Yan, D. L. S. & Potier, M. (1981). Gene for neuraminidase activity on mouse chromosome 17 near H-2: pleiotropic effects on multiple hydrolases. Science 212, 63–65.Google Scholar