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Distorter genes of the mouse t-complex impair male fertility when heterozygous

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon
Mary F. Lyon
Affiliation:
M.R.C. Radiobiology Unit, Chilton, Didcot, Oxon OX11 ORD, U.K.
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Male mice heterozygous for two distorter genes, Tcd-1 and Tcd-2, of the mouse t-complex but homozygous wild type for the responder, were generated by crossing animals carrying the partial t-haplotypes th51 and th18 to inbred strains. The fertility of these males was then compared with that of their brothers carrying normal chromosome 17s. On three of the inbred backgrounds used, C3H/HeH, C57BL/6J and TFH/H, the th51th18 + / + + + males were significantly less fertile than their normal sibs. With the fourth inbred strain used, SM/JH, both types of male were nonnally fertile. This confirmed earlier preliminary findings that when both homologues of chromosome 17 carry wild-type alleles of the responder, heterozygosity for the distorter genes is sufficient to impair fertility, but the effect varies with genetic background. These results are consistent with the concept that both the transmission ratio distortion and the male sterility caused by the t-complex are due to harmful effects of the distorter genes on wild-type alleles of the responder.

Type
Research Article
Information
Genetics Research , Volume 49 , Issue 1 , February 1987 , pp. 57 - 60
Copyright
Copyright © Cambridge University Press 1987

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