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Direct and correlated responses to selection for plasma thyroxine levels in mice

Published online by Cambridge University Press:  14 April 2009

N. Tilakaratne ,
W. G. Hill  and
R. B. Land
N. Tilakaratne
Affiliation:
Institute of Animal Genetics, West Mains Road, Edinburgh EH9 3JN
W. G. Hill
Affiliation:
Institute of Animal Genetics, West Mains Road, Edinburgh EH9 3JN
R. B. Land
Affiliation:
ARC Animal Breeding Research Organisation, West Mains Road, Edinburgh EH9 3JQ
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Selection was carried out in mice for concentration of thyroxine hormone (T4) in plasma of males at 11 weeks of age over seven generations. Selection was practised for high level in two replicate lines and for low level in two replicate lines, and there was an unselected control. There was a response in both directions, and the divergence of 12·4 ng/ml observed in generation seven was equivalent to about 20% of the base population mean or nearly one phenotypic standard deviation. The realised heritability was 9%.

Plasma thyroxine level had a repeatability of 0·54 when two measurements were made 24 h apart. The responses made at 11 weeks in males were also evident in both males and females at 5 weeks. Plasma tri-iodo thyronine (T3) concentrations showed a correlated response almost as large, relative to the mean level, as that in T4.

Positive correlated responses were observed in total weights of the litter at 12 days, and in individual weights at 3, 6 and 9 weeks, the responses in the early weights being greater relative to their mean. The results suggest that the correlated weight changes were due to genetic responses in maternal characteristics, probably milk production, rather than individual growth.

Type
Research Article
Information
Genetics Research , Volume 38 , Issue 2 , October 1981 , pp. 157 - 169
Copyright
Copyright © Cambridge University Press 1981

References

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