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Copper localization in the duodenal mucosa of heterozygous tortoiseshell (Moto/+) female mice (Mus musculus)

Published online by Cambridge University Press:  14 April 2009

Harold J. Sheedlo  and
Melvin L. Beck
Harold J. Sheedlo
Affiliation:
Department of Biology, Memphis State University, Memphis, Tennessee 38152
Melvin L. Beck
Affiliation:
Department of Biology, Memphis State University, Memphis, Tennessee 38152
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Summary

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The duodenal mucosa of normal (+/+) and heterozygous tortoiseshell (Moto / +) female mice was analysed by an ultrastructural histochemical copper localization technique. Copper was rarely detected along the duodenal microvilli of + / + female mice. However, copper was localized on the surface of the brush border of the duodenal mucosa and within pinocytotic vesicles at the base of the microvilli of Moto /+ female mice. The mottled defect may involve a defective intestinal uptake of copper, as well as a faulty copper transport mechanism.

Type
Short Paper
Information
Genetics Research , Volume 38 , Issue 3 , December 1981 , pp. 333 - 336
Copyright
Copyright © Cambridge University Press 1981

References

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