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Controlling elements in the mouse X-chromosome

II. Location in the linkage map

Published online by Cambridge University Press:  14 April 2009

B. M. Cattanach ,
J. N. Perez  and
C. E. Pollard
B. M. Cattanach
Affiliation:
Department of Biology, City of Hope Medical Center, Duarte, California, U.S.A.
J. N. Perez
Affiliation:
Department of Biology, City of Hope Medical Center, Duarte, California, U.S.A.
C. E. Pollard
Affiliation:
Department of Biology, City of Hope Medical Center, Duarte, California, U.S.A.
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The frequency and nature of the changes in ‘state’ of the mouse X-chromosome controlling element (inactivation centre) have been investigated on an inbred background. The results indicate with near-certainty that meiotic crossing over is the responsible mechanism and that the frequency of recombination between the T(1; X)Ct breakpoint and the locus of the controlling element is approximately 3%. Maize-type ‘changes in state’ may occur under other experimental conditions. The data do not distinguish on which side of the autosomal insertion the element lies but when combined with observations of other investigators suggest that the location must be on the Mo-Ta side and very close to Ta.

Type
Research Article
Information
Genetics Research , Volume 15 , Issue 2 , April 1970 , pp. 183 - 195
Copyright
Copyright © Cambridge University Press 1970

References

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