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Controlling elements in the mouse X-chromosome III. Influence upon both parts of an X divided by rearrangement

Published online by Cambridge University Press:  14 April 2009

B. M. Cattanach
B. M. Cattanach
Affiliation:
M.R.G. Radiobiology Unit, Harwell, Berks,* and City of Hope Medical Center, Duarte, California†
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Summary

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Data are presented which support the conclusion that in the flecked translocation, T (1; X) Ct, there is a spread of inactivation into both sides of the autosomal region inserted into the X. This would indicate that both parts of the divided X are subject to the X-inactivation process. The data also demonstrate that the inactivation of autosomal genes lying near each end of the insertion are modified by the X-chromosome controlling element system, Xce. Since the element modifies the heterozygous expression of X-linked genes on one side of the insertion, it would therefore be expected that it similarly modifies the heterozygous phenotypes of those on the other side. The data thus support the concept that the controlling element is the master gene, receptor site or inactivation centre which regulates the X inactivation process.

Type
Research Article
Information
Genetics Research , Volume 16 , Issue 3 , December 1970 , pp. 293 - 301
Copyright
Copyright © Cambridge University Press 1970

References

REFERENCES

Baker, W. K. (1968). Position effect variegation. Advances in Genetics 14, 133–169.CrossRefGoogle ScholarPubMed
Cattanach, B. M. (1961). A chemically-induced variegated-type position effect in the mouse. Zeitschrift fur Vererbungslehre 92, 165–182.Google ScholarPubMed
Cattanach, B. M. (1963). The inactive-X hypothesis and position effects in the mouse. Genetics 48, 884–885.Google Scholar
Cattanach, B. M. (1970). Mouse News Letter 43, 27.Google Scholar
Cattanach, B. M. & Isaacson, J. H. (1965). Genetic control over the inactivation of autosomal genes attached to the X-chromosome. Zeitschrift fur Vererbungslehre 96, 313–323.Google ScholarPubMed
Cattanach, B. M. & Isaacson, J. H. (1967). Controlling elements in the mouse X chromosome. Genetics 57, 331–346.CrossRefGoogle ScholarPubMed
Cattanach, B. M. & Perez, J. N. (1969). Parental influence on X-autosome translocationinduced variegation in the mouse. Genetical Research 15, 43–53.CrossRefGoogle Scholar
Cattanach, B. M., Perez, J. N. & Pollard, C. E. (1970). Controlling elements in the mouse X chromosome. II. Location in the linkage map. Genetical Research, 15, 183–195.CrossRefGoogle ScholarPubMed
Cattanach, B. M., Pollard, C. E. & Perez, J. N. (1970). Controlling elements in the mouse X chromosome. I. Interaction with the X-linked genes. Genetical Research 14, 223–235.CrossRefGoogle Scholar
Chu, E. H. Y. & Russell, L. B. (1965). Pattern of DNA synthesis in X-autosome translocations in the mouse. Genetics 52, 435.Google Scholar
Dunn, L. C. & Bennett, D. (1967). Sex differences in recombination of X-linked genes in animals. Genetical Research 9, 211–220.CrossRefGoogle Scholar
Eicher, E. M. (1967). Genetic extent of the insertion involved in the flecked translocation in the mouse. Genetics 55, 203–212.CrossRefGoogle ScholarPubMed
Eicher, E. M. (1969). X-autosome translocations in the mouse: Total inactivation versus partial inactivation of the X chromosome. Advances in Genetics (in the Press).Google Scholar
Eicher, E. M. (1970). The position of ru-2 and qv with respect to the flecked translocation in the mouse. Genetics 64, 495–510.CrossRefGoogle Scholar
Evans, H. G., Ford, C. E., Lyon, M. F. & Gray, J. (1965). DNA replication and genetic expression in female mice with morphologically distinguishable X chromosomes. Nature 206, 900–903.CrossRefGoogle ScholarPubMed
Ford, C. E. & Evans, E. P. (1964). A reciprocal translocation in the mouse between the X chromosome and a short autosome. Cytogenetics 3, 295–305.CrossRefGoogle Scholar
Grumbach, M. M. (1964). Session I. Discussion, pp. 62–67. Second International Conference on Congenital Malformations. New York: International Medical Congress Ltd.Google Scholar
Lewis, E. B. (1950). The phenomenon of position effect variegation. Advances in Genetics 3, 73–115.CrossRefGoogle Scholar
Lyon, M. F. (1961). Gene action in the X chromosome of the mouse. (Mus musculus L.). Nature 190, 372–373.CrossRefGoogle ScholarPubMed
Lyon, M. F. (1963). Attempts to test the inactive-X theory of dosage compensation in mammals. Genetical Research 4, 93–104.CrossRefGoogle Scholar
Lyon, M. F. (1964). Session I. Discussion, pp. 67–68. Second International Conference on Congenital Malformations. New York: International Medical Congress, Ltd.Google Scholar
Nesbitt, M. N. & Gartler, S. M. (1970). Replication of the mouse sex chromosomes early in the S period. Cytogenetics 9, 212–221.CrossRefGoogle ScholarPubMed
Russell, L. B. (1963). Mammalian X-chromosome action: Inactivation limited in spread and in region of origin. Science 140, 976–978.CrossRefGoogle ScholarPubMed
Russell, L. B. (1964). Another look at the single-active-X hypothesis. Transactions of the New York Academy of Science 26, 726–736.CrossRefGoogle Scholar
Russell, L. B. & Montgomery, C. L. (1969). Comparative studies on X-autosome translocations in the mouse. I. Origin, viability, fertility, and weight of five T (X; 1)'s. Genetics 63, 103–120.CrossRefGoogle ScholarPubMed
Wolfe, H. G. (1967). Mapping the hemoglobin locus in mice transmitting the flecked trans-location. Genetics 55, 213–218.CrossRefGoogle Scholar