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The coalescent process in models with selection, recombination and geographic subdivision

Published online by Cambridge University Press:  14 April 2009

Norman Kaplan ,
Richard R. Hudson  and
Masaru Iizuka
Norman Kaplan*
Affiliation:
National Institute of Environmental Health Sciences, P. O. Box 12233, Research Triangle Park, N. C. 27709, USA
Richard R. Hudson
Affiliation:
Department of Ecology and Evolutionary Biology, University of California at Irvine, Irvine, CA 92717, USA
Masaru Iizuka
Affiliation:
General Education Course, Chikushi Jogakuen Junior College, Ishizaka 2-12-1, Dazaifu-shi, Fukuoka-ken 818-01, Japan
*
*Corresponding author.

Summary

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A population genetic model with a single locus at which balancing selection acts and many linked loci at which neutral mutations can occur is analysed using the coalescent approach. The model incorporates geographic subdivision with migration, as well as mutation, recombination, and genetic drift of neutral variation. It is found that geographic subdivision can affect genetic variation even with high rates of migration, providing that selection is strong enough to maintain different allele frequencies at the selected locus. Published sequence data from the alcohol dehydrogenase locus of Drosophila melanogaster are found to fit the proposed model slightly better than a similar model without subdivision.

Type
Research Article
Information
Genetics Research , Volume 57 , Issue 1 , February 1991 , pp. 83 - 91
Copyright
Copyright © Cambridge University Press 1991

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