Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-26T12:59:30.476Z Has data issue: false hasContentIssue false
  • English
  • Français

Behavioural changes as a correlated response to selection

Published online by Cambridge University Press:  14 April 2009

Ingrid S. Holmes  and
Ian M. Hastings
Ingrid S. Holmes
Affiliation:
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT
Ian M. Hastings*
Affiliation:
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT
*
* Corresponding author.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Lines of mice have been selected for up to 50 generations on the following traits: high body weight, low body weight, high fat content or low fat content. The lines selected for high or low body weight differ by a factor of 2·5 and those selected for high or low fat content differ by a factor of five, both traits measured in 10 week old males. A set of behavioural traits was measured to ascertain whether this selection had caused correlated responses in behaviour: studies included feeding behaviour, open field behaviour, ultrasound calling rates of pups, and the response to the introduction of a novel physical object. Alterations in behavioural patterns which were expected a priori were observed but there appeared to be no changes in behaviour associated with any one selection criterion. Estimates of the genetic correlations between selected and behavioural traits were, with one exception, generally less than 0·1 in magnitude and not significantly different from zero (the exception was food intake in lines selected on body weight). Assuming that mice are accurate models for commercial species, then these results have important implications for animal welfare: they demonstrate that large scale behavioural changes do not arise as an inevitable consequence of intense long-term selection on traits of economic importance in commercial species

Type
Research Article
Information
Genetics Research , Volume 66 , Issue 1 , August 1995 , pp. 27 - 33
Copyright
Copyright © Cambridge University Press 1995

References

Asante, E. A., Hill, W. G., & Bulfield, G. (1989). Analysis of lines of mice selected for fat content. 1. Correlated responses in the activities of NADPH-generating enzymes. Genetical Research 54, 155–160.CrossRefGoogle ScholarPubMed
Bannister, D. W., Lee, A., Whitehead, C. C., & Griffin, H. D. (1984). Lipogenic enzyme activity and fructose 2, 6-biphosphate concentration in livers of two lines of domestic fowl selected for different body fat content. International Journal of Biochemistry 16, 1301–1305.CrossRefGoogle ScholarPubMed
Beniwal, B. K., Hastings, I. M., Thompson, R., & Hill, W. G. (1992 a). Estimation of changes in genetic parameters in selected lines of mice using REML with an animal model. 1. Lean mass. Heredity 69: 352–360.CrossRefGoogle ScholarPubMed
Beniwal, B. K., Hastings, I. M., Thompson, R., & Hill, W. G. (1992 b). Estimation of changes in genetic parameters in selected lines of mice using REML with an animal model. II. Body weight, body composition and litter size. Heredity 69, 361–371.CrossRefGoogle Scholar
Boake, C. R. B. (1994). Quantitative Genetic Studies of Behavioural Evolution. Chicago: University of Chicago Press.Google Scholar
Broadhurst, P. L. (1975). The Maudsley reactive and non-reactive strains of rats: a survey. Behaviour Genetics 5, 299–319.CrossRefGoogle Scholar
DeFries, J. C., Gervais, M. C., & Thomas, E. A. (1978). Response to 30 generations of selection for open field activity in laboratory mice. Behaviour Genetics 8, 3–13.CrossRefGoogle ScholarPubMed
Eisen, E. J. (1989). Selection experiments for body composition in mice and rats: a review. Livestock Production Science 23, 17–32.CrossRefGoogle Scholar
Falconer, D. S. (1953). Selection for large and small size in mice. Journal of Genetics 51, 470–501.CrossRefGoogle Scholar
Falconer, D. S. (1989). An Introduction to Quantitative Genetics, 3rd Edition. Longman, U.K.Google Scholar
Fowler, R. E. (1962). The efficiency of food utilization, digestibility of foodstuffs and energy expenditure of mice selected for large or small body size. Genetical Research 3, 51–68.CrossRefGoogle Scholar
Genstat 5 Committee, (1988). Genstat 5 Reference Manual. Oxford: Oxford University Press.Google Scholar
Hastings, I. M. (1989). Genetic and Biochemical Analyses of Growth. Ph.D. thesis, University of Edinburgh.Google Scholar
Hastings, I. M., & Hill, W. G. (1989). A note on the effects of different selection criteria on carcass composition in mice. Animal Production 48, 229–233.CrossRefGoogle Scholar
Hastings, I. M., & Hill, W. G. (1990). Analysis of lines of mice selected for fat content. 2. Correlated responses in the activities of enzymes involved in lipogenesis. Genetical Research 55, 55–61.CrossRefGoogle ScholarPubMed
Hastings, I. M., & Hill, W. G. (1993). The effect of cage type on murine body composition. Mouse Genome 91, 329–330.Google Scholar
Hastings, I. M., Yang, J., & Hill, W. G. (1991). Analysis of lines of mice selected on fat content. 4. Correlated responses in growth and reproduction. Genetical Research 58, 253–259.CrossRefGoogle ScholarPubMed
Hay, D. A. (1985). Essentials of Behavioural Genetics. Blackwell Scientific, U.K.Google Scholar
HMSO (1974). Food and Nutrition Research.Google Scholar
Lynch, C. B. (1980). Response to divergent selection for nesting behaviour in Mus musculus. Genetics 96, 757–765.CrossRefGoogle ScholarPubMed
MacArthur, J. W. (1944). Genetics of body size and related characters. American Naturalist 78, 224–237.CrossRefGoogle Scholar
Muller, E. (1986). Physiological and biochemical indicators of growth and composition. In Exploiting new Technologies in Animal Breeding, Genetic Developments, (ed. Smith, C., King, B., and McKay, J. C.). Oxford Science Publications.Google Scholar
Patterson, H. D., & Thompson, R. (1971). Recovery of inter-block information when block sizes are unequal. Biometrika 58, 545–554.CrossRefGoogle Scholar
Rankin, J., & Manning, A. (1993). Alterations to the pattern of ultrasound calling after prenatal exposure to aluminium sulphate. Behavioural and Neural Biology 59, 136–142.CrossRefGoogle Scholar
Sharp, G. L., Hill, W. G., & Robertson, A. (1984). Effects of selection on growth, body composition and food intake in mice. I. Responses in selected traits. Genetical Research 43, 75–92.CrossRefGoogle ScholarPubMed
Van Oortmerssen, G. A., & Bakker, T. C. M. (1981). Artificial selection for short and long attack latencies in wild Mus musculus domesticus. Behavioural Genetics 11, 115–126.CrossRefGoogle Scholar
Wahlston, D. (1978). Genetic experiments with animal learning: a critical review. Behavioural Biology 1, 143–152.Google Scholar
Zbinden, G. (1981). Experimental methods in behavioural teratology. Archives of Toxicology 48, 69–88.CrossRefGoogle Scholar