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Bare-patches, a new sex-linked gene in the mouse, associated with a high production of XO females: II. Investigations into the nature and mechanism of the XO production

Published online by Cambridge University Press:  14 April 2009

Rita J. S. Phillips  and
M. H. Kaufman
Rita J. S. Phillips
Affiliation:
M.R.C. Radiobiology Unit, Harwell, Didcot OX11 0RD, England
M. H. Kaufman
Affiliation:
Physiology Laboratory, Cambridge, England
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The high XO production in Bpa+ mouse stocks appears to be due, not to Bpa itself, but to a closely linked factor for high XO production (Fxo) which may be a gene or a chromosomal aberration. The change of Bpa Fxo to Bpa non-Fxo occurs with a frequency of about 6%; the reciprocal change from Bpa Fxo to Fxo non-Bpa has not been found. There is some evidence that Fxo might involve a structural alteration such as an inversion or a deletion. The X-chromosome loss is due to non-disjunction which occurs in about one-third of the oocytes, probably mainly at meiosis I. Frequencies of other chromosomal abnormalities found in the stocks are given.

Type
Research Article
Information
Genetics Research , Volume 24 , Issue 1 , August 1974 , pp. 27 - 41
Copyright
Copyright © Cambridge University Press 1974

References

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