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Assignment of the mouse desmin gene to chromosome 1 band C3

Published online by Cambridge University Press:  14 April 2009

Zhenlin Li
Affiliation:
Laboratoire de Biologie Moléculaire de la Différenciation de l'Université Paris 7 et de l'Institut Pasteur – 25, rue du Docteur Roux – 75754, Paris
Marie-Geneviève Mattei
Affiliation:
INSERM U. 242 Centre de génétique médicale, Hôpital d'enfants de la Timone, 13385 Marseille Cedex, France
Jean-François Mattei
Affiliation:
INSERM U. 242 Centre de génétique médicale, Hôpital d'enfants de la Timone, 13385 Marseille Cedex, France
Denise Paulin*
Affiliation:
Laboratoire de Biologie Moléculaire de la Différenciation de l'Université Paris 7 et de l'Institut Pasteur – 25, rue du Docteur Roux – 75754, Paris
*
Corresponding author: Denise Paulin, Institut Pasteur SCME, 25 rue du Dr Roux, 75015 Paris.
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The chromosomal localization of the mouse gene coding for desmin, one of the muscle-specific intermediate filament subunits, was determined by in situ hybridization using a specific 3H-labelled DNA probe. There is only one copy of the desmin gene and it is located on chromosome 1 in the band C3. This result adds an eleventh locus to a conserved gene cluster and confirms the partial homology that exists between the long arm of human chromosome 2 and chromosome 1 of the mouse.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1990

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