Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-27T07:54:29.253Z Has data issue: false hasContentIssue false
  • English
  • Français

An attempt to estimate the effective size of the ancestral species common to two extant species from which homologous genes are sequenced

Published online by Cambridge University Press:  14 April 2009

Naoyuki Takahata
Naoyuki Takahata
Affiliation:
National Institute of Genetics, Mishima, Shizuoka-ken, 411Japan
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

When DNA sequence data on various kinds of homologous genes sampled from two related species are available, there is a way to infer the effective size of their ancestral species, which is a simple consequence of gene genealogical considerations. This method, when applied to the common ancestral species of human and rat, human and mouse, human and bovine, or rodents and bovine estimates their effective sizes all to be of the order of 107, supporting the view that these species indeed shared, around 75 million years ago, a common ancestral species from which they are descended. The effective size thus estimated would imply that the ancestral species was abundant enough to have ample opportunity for adaptive radiation. The extent of silent polymorphism in that species might have been very large, possibly comparable to the number of silent substitutions accumulated in a gene after the mammalian divergence. Some causes that may alter these results and require a more elaborated statistical analysis are discussed.

Type
Short Paper
Information
Genetics Research , Volume 48 , Issue 3 , December 1986 , pp. 187 - 190
Copyright
Copyright © Cambridge University Press 1986

References

Britten, R. J. (1986). Rates of DNA sequence evolution differ between taxonomic groups. Science 231, 1393–1398.CrossRefGoogle ScholarPubMed
Gillespie, J. H. & Langley, C. H. (1979). Are evolutionary rates really variable? Journal of Molecular Evolution 13, 27–34.CrossRefGoogle ScholarPubMed
Golding, G. B. & Strobeck, C. (1982). The distribution of nucleotide site differences between two finite sequences. Theoretical Population Biology 22, 96–107.CrossRefGoogle ScholarPubMed
Hayashida, H. & Miyata, T. (1983). Unusual evolutionary conservation and frequent DNA segment exchange in class I genes of the major histocompatibility complex. Proceedings of the National Academy of Sciences, USA 80, 2671–2675.CrossRefGoogle ScholarPubMed
Hudson, R. R. (1983). Properties of a neutral allele model with intragenic recombination. Theoretical Population Biology 23, 203–217.CrossRefGoogle ScholarPubMed
Kimura, M. (1971). Theoretical foundations of population genetics at the molecular level. Theoretical Population Biology 1, 174–208.CrossRefGoogle Scholar
Kimura, M. (1981). Estimation of evolutionary distances between homologous nucleotide sequences. Proceedings of the National Academy of Sciences, USA 78, 454–458.CrossRefGoogle ScholarPubMed
Kimura, M. (1983). The Neutral Theory of Molecular Evolution. Cambridge: Cambridge University Press.CrossRefGoogle Scholar
Kingman, J. F. C. (1982). On the genealogy of large populations. Journal of Applied Probability 19A, 27–43.CrossRefGoogle Scholar
Kreitman, M. (1983). Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster. Nature 304, 412–417.CrossRefGoogle ScholarPubMed
Koop, B. F., Goodman, M., Xu, P., Chan, K. & Slightom, J. L. (1986). Primate η-globin DNA sequences and man's place among the great apes. Nature 319, 234–237.CrossRefGoogle ScholarPubMed
Li, W.-H. (1977). Distribution of nucleotide differences between two randomly chosen cistrons in a finite population. Genetics 85, 331–337.CrossRefGoogle Scholar
Miyata, T. & Hayashida, H. (1981). Extraordinarily high evolutionary rate of pseudogenes: evidence for the presence of selective pressure against changes between synonymous codons. Proceedings of the National Academy of Sciences, USA 78, 5739–5743.CrossRefGoogle ScholarPubMed
Stephens, J. C. & Nei, M. (1985). Phylogenetic analysis of polymorphic DNA sequences at the Adh locus in Drosophila melanogaster and its sibling species. Journal of Molecular Evolution 22, 289–300.CrossRefGoogle ScholarPubMed
Tajima, F. (1983). Evolutionary relationship of DNA sequences in finite populations. Genetics 105, 437–460.CrossRefGoogle ScholarPubMed
Takahata, N. (1982). Linkage disequilibrium, genetic distance and evolutionary distance under a general model of linked genes or a part of the genome. Genetical Research 39, 63–77.CrossRefGoogle Scholar
Takahata, N. (1985). Gene diversity in finite populations. Genetical Research 46, 107–113.CrossRefGoogle ScholarPubMed
Takahata, N. & Nei, M. (1985). Gene genealogy and variance of interpopulational nucleotide differences. Genetics 110, 325–344.CrossRefGoogle ScholarPubMed
Tavaré, S. (1984). Line-of-descent and genealogical process, and their applications in population genetics models. Theoretical Population Biology 26, 119–164.CrossRefGoogle ScholarPubMed
Watterson, G. A. (1975). On the number of segregating sites in genetical models without recombination. Theoretical Population Biology 7, 256–276.CrossRefGoogle ScholarPubMed
Wu, C.-I. & Li, W.-H. (1985). Evidence for higher rates of nucleotide substitution in rodents than in man. Proceedings of the National Academy of Sciences, USA 82, 1741–1745.CrossRefGoogle ScholarPubMed