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Allelism tests of 15 dominant cataract mutations in mice

Published online by Cambridge University Press:  14 April 2009

J. Kratochvilova  and
J. Favor
J. Kratochvilova*
Affiliation:
GSF-Institut für Säugetiergenetik, D-8042 Neuherberg, Federal Republic of Germany
J. Favor
Affiliation:
GSF-Institut für Säugetiergenetik, D-8042 Neuherberg, Federal Republic of Germany
*
* Corresponding author.

Summary

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Fifteen autosomal dominant mutations that cause cataract of lenses in mice were tested for allelism. The outcrosses of double mutants revealed three allelism groups, consisting of 5, 4 and 2 mutations as well as 4 mutations which segregated independently. The results indicated 7 different cataract loci in the sample of 15 mutations. The biomicroscopic examination of the eyes showed that phenotypically similar as well as very distinct cataract mutations can be alleles of the same gene. Conversely, phenotypically similar mutations were shown to be non-allelic.

Type
Research Article
Information
Genetics Research , Volume 59 , Issue 3 , June 1992 , pp. 199 - 203
Copyright
Copyright © Cambridge University Press 1992

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