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The action of the gene prune (pn) in Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

Eliezer Lifschytz  and
Raphael Falk
Eliezer Lifschytz
Affiliation:
Laboratory of Genetics, The Hebrew University, Jerusalem, Israel
Raphael Falk
Affiliation:
Laboratory of Genetics, The Hebrew University, Jerusalem, Israel
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The gene pn was found to be active already in larvae 30 h old, long before eye-pteridines accumulated. At this developmental stage pn interacts with the gene K-pn. From studies with induced somatic recombination, gynandromorphs, and induced pn mutations, in a K-pn background it was concluded that the interaction pn-K-pn is non-autonomous in the epidermis, but in some internal organs it is apparently autonomous and causes the death of pn–K-pn flies. It is proposed that pn mutants interfere with an early step of the conversion of guanosine to pteridine, so that a deficiency of drosopterines, but not of the competing sepiapterine and biopterine, is caused. The accumulated precursor is presumably the substrate for a poisonous reaction triggered by K-pn.

Type
Research Article
Information
Genetics Research , Volume 14 , Issue 1 , August 1969 , pp. 53 - 61
Copyright
Copyright © Cambridge University Press 1969

References

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