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A SYSTEMATIC REVIEW OF MATERNAL CALCIUM SUPPLEMENTATION AND PAEDIATRIC HEALTH

Published online by Cambridge University Press:  16 June 2015

SHOROK ALI AL DORAZI  and
WASEEM AL TALALWAH
SHOROK ALI AL DORAZI*
Affiliation:
Directorate of Prevention and Control of Healthcare Associated Infection, Eastern Province, MOH, KSA, Saihat, Kingdom of Saudi Arabia.
WASEEM AL TALALWAH
Affiliation:
King Abdullah International Medical Research Center/King Saud bin Abdulaziz College of Medicine, Department of Basic Medical Sciences, Hospital, University for Health Sciences, – NGHA, Riyadh, Saudi Arabia.
*
Shorok Ali Al Dorazi, Dr, Directorate of Prevention and Control of Healthcare Associated Infection, Eastern Province, MOH, KSA, Saihat 31972, Kingdom of Saudi Arabia. Email: [email protected]
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Extract

Calcium is an important element of body composition1,2 as well as normal physiological functions3 . A neonate's body has around 20–30 g calcium present at birth2,4–6 and this amount has to be supplied by the mother since human body cannot synthesise calcium2 . Therefore, if the mother has a shortage of calcium, the foetus might be affected.

Type
Review Article
Information
Fetal and Maternal Medicine Review , Volume 25 , Issue 3-4 , November 2014 , pp. 178 - 196
Copyright
Copyright © Cambridge University Press 2015 

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References

REFERENCES

1. Heaney, RP. The importance of calcium intake for lifelong skeletal health. Calcif Tissue Int 2002; 70 (2): 70–3.Google Scholar
2. Thomas, M, Weisman, SM. Calcium supplementation during pregnancy and lactation: effects on the mother and the fetus. Am J Obstet Gynecol 2006; 194 (4): 937–45.Google Scholar
3. Institute of Medicine. DRI dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. 1997. [online] Available at: http://www.nap.edu/openbook.php?record_id=5776&page=R1 accessed: 20/12/2010.Google Scholar
4. Kovacs, CS. Calcium and bone metabolism in pregnancy and lactation. J Clin Endocrinol Metab 2001; 86 (6): 2344–8.Google Scholar
5. Prentice, A. Micronutrients and the bone mineral content of the mother, fetus and newborn. J Nutr 2003; 133 (5 Suppl. 2): 693S–9S.Google Scholar
6. Kovacs, CS, Fuleihan, Gel-H. Calcium and bone disorders during pregnancy and lactation. Endocrinol Metab Clin North Am 2006; 35 (1): 21–51.Google Scholar
7. Prentice, A. Maternal calcium requirements during pregnancy and lactation. Am J Clin Nutr 1994; 59 (Suppl. 2): 477S–82S.Google Scholar
8. Kamau-Mbuthia, E, Elmadfa, I. Diet quality of pregnant women attending an antenatal clinic in Nakuru, Kenya. Ann Nutr Metab 2007; 51 (4): 324–30.Google Scholar
9. Darwish, AM, Mohamad, SN, Gamal Al-Din, HR, Elsayed, YA, Ahmad, SI. Prevalence and predictors of deficient dietary calcium intake during the third trimester of pregnancy: the experience of a developing country. J Obstet Gynaecol Res 2009; 35 (1): 106–12.CrossRefGoogle ScholarPubMed
10. The Standing Committee on Nutrition of the United Nations System. Global recession developing countries: pregnant increases malnutrition for the most vulnerable people in women and children are hardest hit. 2009 [online] Available at: http://www.unscn.org/files/Publications/Briefs_on_Nutrition/SCN_Nutrition_Impacts_of_Financial_Crisis_4p.pdf accessed: 21/12/2010.Google Scholar
11. Raman, L, Rajalakshmi, K, Krishnamachari, KA, Sastry, JG. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the bone density of the neonates. Am J Clin Nutr 1978; 31 (3): 466–9.Google Scholar
12. Villar, J, Repke, JT. Calcium supplementation during pregnancy may reduce preterm delivery in high-risk populations. Am J Obstet Gynecol 1990; 163 (4 Pt 1): 1124–31.Google Scholar
13. Jarjou, LM, Prentice, A, Sawo, Y, Laskey, MA, Bennett, J, Goldberg, GR et al. Randomized, placebo-controlled, calcium supplementation study in pregnant Gambian women: effects on breast-milk calcium concentrations and infant birth weight, growth, and bone mineral accretion in the first year of life. Am J Clin Nutr 2006; 83 (3): 657–66.Google Scholar
14. Kumar, A, Devi, SG, Batra, S, Singh, C, Shukla, DK. Calcium supplementation for the prevention of pre-eclampsia. Int J Gynaecol Obstet 2009; 104 (1): 32–6.Google Scholar
15. Abalos, E, Merialdi, M, Wojdyla, D, Carroli, G, Campodónico, L, Yao, SE et al. Effects of calcium supplementation on fetal growth in mothers with deficient calcium intake: a randomised controlled trial. Paediatr Perinat Epidemiol 2010; 24 (1): 53–62.Google Scholar
16. Belizán, JM, Villar, J, Bergel, E, del Pino, A, Di Fulvio, S, Galliano, SV et al. Long-term effect of calcium supplementation during pregnancy on the blood pressure of offspring: follow up of a randomised controlled trial. BMJ 1997; 315 (7103): 281–5.Google Scholar
17. Hiller, JE, Crowther, CA, Moore, VA, Willson, K, Robinson, JS. Calcium supplementation in pregnancy and its impact on blood pressure in children and women: follow up of a randomized controlled trial. Aus N Z J Obstet Gynaecol 2007; 47 (2): 115–21.Google Scholar
18. Hawkesworth, S, Sawo, Y, Fulford, AJ, Goldberg, GR, Jarjou, LM. Prentice A, Moore SE. Effect of maternal calcium supplementation on offspring blood pressure in 5- to 10-y-old rural Gambian children. Am J Clin Nutr 2010; 92 (4): 741–7.Google Scholar
19. Bucher, HC, Guyatt, GH, Cook, RJ, Hatala, R, Cook, DJ, Lang, JD et al. Effect of calcium supplementation on pregnancy-induced hypertension and preeclampsia: a meta-analysis of randomized controlled trials. JAMA 1996; 275 (14): 1113–7.Google Scholar
20. Hofmeyr, GJ, Atallah, ÁN, Duley, L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev (3). Art. 2006. No.: CD001059. doi: 10.1002/14651858.CD001059.pub2.Google Scholar
21. Hofmeyr, GJ, Lawrie, TA, Atallah, ÁN, Duley, L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 4 (8). Art. 2010. No.: CD001059. doi:10.1002/14651858.CD001059.pub3.Google Scholar
22. Levine, RJ, Esterlitz, JR, Raymond, EG, DerSimonian, R, Hauth, JC, Ben Curet, L et al. Trial of calcium for preeclampsia prevention (CPEP): rationale, design, and methods. Control Clin Trials 1996; 17 (5): 442–69.Google Scholar
23. Higgins, JPT, Green, S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2. 2009 [updated September 2009]. The Cochrane Collaboration. Available at: www.cochrane-handbook.org. accessed on 11/12/2010.Google Scholar
24. Belizán, JM, Villar, J, Zalazar, A, Rojas, L, Chan, D, Bryce, GF. Preliminary evidence of the effect of calcium supplementation on blood pressure in normal pregnant women. Am J Obstet Gynecol 1983; 146 (2): 175–80.Google Scholar
25. Ettinger, AS, Lamadrid-Figueroa, H, Téllez-Rojo, MM, Mercado-García, A, Peterson, KE, Schwartz, J et al. Effect of calcium supplementation on blood lead levels in pregnancy: a randomized placebo-controlled trial. Environ Health Perspect 2009; 117 (1): 26–31.Google Scholar
26. Levine, RJ, Hauth, JC, Curet, LB, Sibai, BM, Catalano, PM, Morris, CD et al. Trial of calcium to prevent preeclampsia. N Engl J Med 1977; 337 (2): 69–76.CrossRefGoogle Scholar
27. Koo, WW, Walters, J, Esterlitz, J, Levine, RJ, Bush, AJ, Sibai, B. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999; 94 (4): 577–82.Google Scholar
28. Hatton, DC, Harrison-Hohner, J, Coste, S, Reller, M, McCarron, D. Gestational calcium supplementation and blood pressure in the offspring. Am J Hypertens 2003; 16 (10): 801–5.Google Scholar
29. Jarjou, LM, Prentice, A, Bennett, J. Impact of calcium supplementation in the preceding pregnancy on the human milk calcium concentration of Gambian women. Adv Exp Med Biol 2004; 554: 347–9.Google Scholar
30. Belizán, JM, Villar, J, Gonzalez, L, Campodonico, L, Bergel, E. Calcium supplementation to prevent hypertensive disorders of pregnancy. N Engl J Med 1991; 325 (20): 1399–405.Google Scholar
31. López-Jaramillo, P, Delgado, F, Jácome, P, Terán, E, Ruano, C, Rivera, J. Calcium supplementation and the risk of preeclampsia in Ecuadorian pregnant teenagers. Obstet Gynecol 1997; 90 (2): 162–7.Google Scholar
32. Crowther, CA, Hiller, JE, Pridmore, B, Bryce, R, Duggan, P, Hague, WM et al. Calcium supplementation in nulliparous women for the prevention of pregnancy-induced hypertension, preeclampsia and preterm birth: an Australian randomized trial. FRACOG and the ACT Study Group. Aus N Z J Obstet Gynaecol 1999; 39 (1): 12–8.CrossRefGoogle ScholarPubMed
33. Villar, J, Abdel-Aleem, H, Merialdi, M, Mathai, M, Ali, MM, Zavaleta, N et al. World health organization calcium supplementation for the prevention of preeclampsia trial group. World health organization randomized trial of calcium supplementation among low calcium intake pregnant women. Am J Obstet Gynecol 2006; 194 (3): 639–49.Google Scholar
34. Abdel-Aleem, H, Merialdi, M, Elsnosy, ED, Elsedfy, GO, Abdel-Aleem, MA, Villar, J. The effect of calcium supplementation during pregnancy on fetal and infant growth: a nested randomized controlled trial within WHO calcium supplementation trial. J Matern Fetal Neonatal Med 2009; 22 (2): 94–100.Google Scholar
35. Jadad, A. Randomised Controlled Trials: A user's Guide. London: BMJ Books; 1998.Google Scholar
36. Beinder, E. Calcium-supplementation in pregnancy-is it a must? Therapeutische Umschau 2007; 64 (5): 243–7.CrossRefGoogle Scholar
37. Karandish, M, Djazayery, A, Mahmoudi, M, Behrooz, A. The effect of calcium supplementation during pregnancy on birth weight. Med J Reprod Infertility 2003; 4 (3): 184.Google Scholar
38. Cong, KJ, Chi, SL, Liu, GR. Calcium supplementation during pregnancy to reduce pregnancy induced hypertension. Beijing Med J 1992; 5: 268.Google Scholar
39. Cong, KJ, Chi, SL, Liu, GR. Calcium and pregnancy induced hypertension. Chin J Obstet Gynecol 1993; 28 (11): 657–9.Google Scholar
40. Cong, KJ, Chi, SL, Liu, GR. Calcium supplementation during pregnancy for reducing pregnancy induced hypertension. Chin Med J (Engl) 1995; 108 (1): 57–9.Google Scholar
41. Bogden, JD, Thind, IS, Louria, DB, Caterini, H. Maternal and cord blood metal concentrations and low birth weight–a case-control study. Am J Clin Nutr 1978; 31 (7): 1181–7.Google Scholar
42. Rees, GA, Doyle, W, Srivastava, A, Brooke, ZM, Crawford, MA, Costeloe, KL. The nutrient intakes of mothers of low birth weight babies - a comparison of ethnic groups in East London, UK. Matern Child Nutr 2005; 1 (2): 91–9.Google Scholar
43. Smolarczyk, R, Wójcicka-Jagodzínska, J, Romejko, E, Piekarski, P, Czajkowski, K, Teliga, J. Calcium-phosphorus-magnesium homeostasis in women with threatened preterm delivery. Int J Gynaecol Obstet 1997; 57 (1): 43–8.CrossRefGoogle ScholarPubMed
44. Ortega, RM, Martínez, RM, Quintas, ME, López-Sobaler, AM, Andrés, P. Calcium levels in maternal milk: relationships with calcium intake during the third trimester of pregnancy. Br J Nutr 1998; 79 (6): 501–7.Google Scholar
45. Straub, DA. Calcium supplementation in clinical practice: a review of forms, doses, and indications. Nutr Clin Pract 2007; 22 (3): 286–96.CrossRefGoogle ScholarPubMed
46. Ulrich, U, Miller, PB, Eyre, DR, Chesnut, CH 3rd, Schlebusch, H, Soules, MR. Bone remodeling and bone mineral density during pregnancy. Arch Gynecol Obstet 2003; 268 (4): 309–16.Google Scholar
47. Drinkwater, BL, Chesnut, CH 3rd. Bone density changes during pregnancy and lactation in active women: a longitudinal study. Bone Miner 1991; 14 (2): 153–60.Google Scholar
48. Brooke, OG, Brown, IR, Bone, CD, Carter, ND, Cleeve, HJ, Maxwell, JD et al. Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth. Br Med J 1980; 280 (6216): 751–4.CrossRefGoogle ScholarPubMed
49. Laboissiere, FP, Bezerra, FF, Rodrigues, RB, King, JC, Donangelo, CM. Calcium homeostasis in primiparae and multiparae pregnant women with marginal calcium intakes and response to a 7-day calcium supplementation trial. Nutrition Res 2000; 20 (9): 1229–39.CrossRefGoogle Scholar