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Sodium balance in pregnancy

Published online by Cambridge University Press:  10 October 2008

Mark A Brown
Mark A Brown*
Affiliation:
Renal Physician and Senior Lecturer in Medicine, Departments of Renal Medicine and Obstetrics, St George Hospital, Kogarah, New South Wales, Australia
*
Dr Mark A Brown, Renal Physician and Senior Lecturer in Medicine, Departments of Renal Medicine and Obstetrics, St George Hospital, Kogarah, New South Wales 2217, Australia.
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Extract

Sodium is the major cation in the extracellular fluid volume (ECFV) and as such, is the most important determinant of osmolality and of the volume of this fluid compartment. Hence any alteration in the control of body sodium will be reflected by changes in the ECFV, including the maternal plasma volume. There is no doubt that expansion of the plasma volume is a necessary and desirable event during pregnancy, influencing positively both maternal and fetal outcome. Therefore, studies of sodium balance in pregnancy provide important information relevant to both mother and fetus.

Type
Articles
Information
Fetal and Maternal Medicine Review , Volume 1 , Issue 2 , July 1989 , pp. 193 - 212
Copyright
Copyright © Cambridge University Press 1989

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References

1 Barron, WM, Lindheimer, MD. Renal sodium and water handling in pregnancy. Obstet Gynecol Ann 1984; 13: 35–69.Google ScholarPubMed
2 Gallery, EDM, Brown, MA. Control of sodium excretion in human pregnancy. Am J Kidney Dis 1987; 9: 290–5.CrossRefGoogle ScholarPubMed
3 Gallery, EDM, Brown, MA. Volume homeostasis in normal and hypertensive human pregnancy. Bailliere's Clinical Obstet Gynaecol 1987; 1: 835–51.CrossRefGoogle ScholarPubMed
4 Brown, MA. Sodium and plasma volume regulation in normal and hypertensive pregnancy: a review of physiology and clinical implications. Clin Exper Hyper 1988; B7: 265–82.Google Scholar
5 Chesley, LC. Hypertensive disorders in pregnancy. New York: Appleton-Century Crofts, 1978: 190.Google Scholar
6 Flexner, LB, Cowie, DB, Hellman, LM, Wilde, WS, Vosburg, GJ. The permeability of the human placenta to sodium in normal and abnormal pregnancies and the supply of sodium to the human fetus as determined with radioactive sodium. Am J Obstet Gynecol 1948; 55: 469–80.CrossRefGoogle Scholar
7 Pirani, BBK, Campbell, DM, MacGillivray, I. Plasma volume in normal first pregnancy. J Obstet Gynaecol Br Commonwlth 1973; 80: 884–87.CrossRefGoogle ScholarPubMed
8 Brown, MA, Prendergast, JS, Ross, MR, Gallery, EDM. Comparing methods to assess dietary sodium intake in pregnancy. J Am Dietetic Ass 1987; 87: 1058–60.CrossRefGoogle ScholarPubMed
9 Oliver, WJ, Neel, JV, Grekin, RJ, Cohen, EL. Hormonal adaptation to the stresses imposed upon sodium balance by pregnancy and lactation in the Yanomama Indians, a culture without salt. Circulation 1981; 63: 110–16.CrossRefGoogle Scholar
10 Brown, JE, Toma, RB. Taste changes during pregnancy. Am J Clin Nutr 1986; 43: 414–18.CrossRefGoogle ScholarPubMed
11 Gray, MJ, Munro, AB, Sims, EAH, Meeker, CI, Solomon, S, Watanabe, M. Regulation of sodium and total body water metabolism in pregnancy. Am J Obstet Gynecol 1964; 89: 760–65.CrossRefGoogle ScholarPubMed
12 Sarles, HE, Hill, SS, LeBlanc, AL, Smith, GH, Canales, CO, Remmers, AR. Sodium excretion patterns during and following intravenous sodium chloride loads in normal and hypertensive pregnancies. Am J Obstet Gynecol 1968; 102: 1–7.CrossRefGoogle ScholarPubMed
13 Lindheimer, MD, Katz, AI. Controlling the kidney in pregnancy. N Engl J Med 1971; 284: 107.Google Scholar
14 Schewitz, LJ. Hypertension and renal disease in pregnancy. Med Clin N America 1971; 55: 47–69.CrossRefGoogle ScholarPubMed
15 Gordon, RD, Symonds, EM, Wilmshurst, EG, Pawsey, CGK. Plasma renin activity, plasma angiotensin and plasma and urinary electrolytes in normal and toxaemic pregnancy, including a prospective study. Clin Sci Mol Med 1973; 45: 115–27.Google ScholarPubMed
16 Gillum, RF, Prineas, RJ, Elmer, PJ. Assessing sodium and potassium intake in essential hypertension. Am Heart J 1984; 107: 549–55.CrossRefGoogle ScholarPubMed
17 Bay, WH, Ferris, TF. Factors controlling plasma renin and aldosterone during pregnancy. Hypertension 1979; 1: 410–15.CrossRefGoogle ScholarPubMed
18 Lindheimer, MD. Hypertension during pregnancy (discussion) In: Hunt, JC ed, Hypertension update. Bloomfield: Health Learning Systems, 1980: 92–93.Google Scholar
19 Ehrlich, EN, Laves, M, Lugibihl, K, Landau, RL. Progesterone-aldosterone interrelationships in pregnancy. J Lab Clin Med 1962; 59: 588–95.Google ScholarPubMed
20 Ehrlich, EN. Reciprocal variations in urinary cortisol and aldosterone in response to increased salt intake in humans. J Clin Endocrinol Metab 1966; 26: 1160–69.CrossRefGoogle ScholarPubMed
21 Ehrlich, EN, Lindheimer, MD. Effect of administered mineralocorticoids or ACTH in pregnant women: attenuation of kaliuretic influence of mineralocorticoids during pregnancy. J Clin Invest 1972; 51: 1301–309.CrossRefGoogle ScholarPubMed
22 Lindheimer, MD, delGreco, F, Ehrlich, EN. Postural effects on sodium and steroid excretion, and serum renin activity during pregnancy. J ApplPhysiol 1973; 35: 343–48.Google Scholar
23 Brown, MA. Sodium excretion in pregnancy. M.D. Thesis, University of New South Wales, 1987.Google Scholar
24 Chesley, LC. Weight changes and water balance in normal and toxic pregnancy. Am J Obstet Gynecol 1944; 48: 565–93.CrossRefGoogle Scholar
25 Dieckmann, WJ, Pottinger, RE, Rynkiewicz, LM. Etiology of pre-eclampsia, IV sodium chloride test for the diagnosis of pre-eclampsia. Am J Obstet Gynecol 1952; 63: 783–91.CrossRefGoogle ScholarPubMed
26 Willson, JR, Williams, JM, Hayashi, TT. Hypertonic saline infusions for the differential diagnosis of the toxemias of pregnancy. Am J Obstet Gynecol 1957; 73: 30–36.CrossRefGoogle Scholar
27 Chesley, LC, Valenti, C, Rein, H. Excretion of sodium loads by nonpregnant and pregnant normal, hypertensive and pre-eclamptic women. Metabolism 1958; 7: 575–88.Google ScholarPubMed
28 Lindheimer, MD, Weston, PV. Effect of hypotonic expansion on sodium, water and urea excretion in late pregnancy: the influence of posture on these results. J Clin Invest 1969; 48: 947–56.CrossRefGoogle ScholarPubMed
29 Lindheimer, MD, Katz, AI. Effects of hypotonic expansion on sodium and water excretion in hypertensive non pre-eclamptic gravidas. Am J Obstet Gynecol 1971; 111: 1053–58.CrossRefGoogle ScholarPubMed
30 Weinberger, MH, Kramer, NJ, Grim, CE, Peterson, LP. The effect of posture and saline loading on plasma renin activity and aldosterone concentration in pregnant, nonpregnant and estrogen-treated women. J Clin Endocrinol Metab 1977; 44: 69–77.CrossRefGoogle ScholarPubMed
31 Brown, MA, Gallery, EDM, Ross, MR, Esber, RP. Sodium excretion in normal and hypertensive pregnancy: a prospective study. Am J Obstet Gynecol 1988; 159: 297–307.CrossRefGoogle ScholarPubMed
32 Hytten, FE, Leitch, I. The physiology of human pregnancy. Second edition. Oxford: Blackwell Scientific, 1971.Google Scholar
33 MacGillivray, I. Pre-eclampsia: the hypertensive disease of pregnancy. London: W B Saunders, 1983: 63.Google Scholar
34 Schrier, RW, Durr, JA. Pregnancy: an overfill or underfill state. Am JKidney Dis 1987; 9: 284–89.CrossRefGoogle ScholarPubMed
35 Chesley, LC. Hypertensive disorders in pregnancy. New York: Appleton-Century Crofts, 1978: 168–80.Google Scholar
36 Gallery, EDM, Hunyor, SM, Gyory, AZ. Plasma volume contraction: a significant factor in both pregnancy-associated hypertension (pre-eclampsia) and chronic hypertension in pregnancy. Q J Med 1979; 48: 593–602.Google ScholarPubMed
37 Gant, NF, Daley, GL, Chand, S, Whalley, PJ, MacDonald, PC. A study of angiotensin II pressor response throughout primigravid pregnancy. J Clin Invest 1973; 52: 2682–89.CrossRefGoogle ScholarPubMed
38 August Taufield, P, Edersheim, TG, Druzin, ML, Mueller, FB, Laragh, JH, Sealey, JE. Blood pressure regulation in normal pregnancy: unmasking the role of the renin angiotensin system with captopril. Sixth International Congress ISSHP, 1988: 60 (abstract).Google Scholar
39 Hollenberg, NK. The renin-angiotensin system and sodium homeostasis. J Cardiovasc Pharmacol 1984; 6: S176–83.CrossRefGoogle ScholarPubMed
40 Peach, MJ. Renin-angiotensin system: biochemistry and mechanism of action. Physiol Rev 1977; 57: 313–70.CrossRefGoogle Scholar
41 Symonds, EM, Stanley, MA, Skinner, SL. Production of renin by in vitro cultures of human chorion and uterine muscle. Nature 1968; 217: 1152–53.CrossRefGoogle ScholarPubMed
42 Franks, RC, Hayashi, RH. Maternal and fetal renin activity and renin and big renin concentrations in second trimester pregnancy. Am J Obstet Gynecol 1979; 134: 20–22.CrossRefGoogle ScholarPubMed
43 Symonds, EM, Craven, DJ, Rodeck, CH. Fetal plasma renin and renin substrate in mid-trimester pregnancy. Br J Obstet Gynaecol 1985; 92: 618–21.CrossRefGoogle ScholarPubMed
44 Lumbars, ER. Activation of renin in human amniotic fluid by low pH. Enzymologia 1971; 40: 329–36.Google Scholar
45 Broughton Pipkin, F. The renin-angiotensin system in normal and hypertensive pregnancies. In: Rubin PC ed, Handbook of hypertension. Hypertension in pregnancy, volume 10. Amsterdam: Elsevier, 1988: 118–51.Google Scholar
46 Weir, RJ, Paintin, DB, Brown, JJ etal. A serial study in pregnancy of the plasma concentrations of renin, corticosteroids, electrolytes, and proteins and of haematocrit and plasma volume. J Obstet Gynaecol Br Commonwlth 1971; 78: 590–602.CrossRefGoogle ScholarPubMed
47 Symonds, EM, Broughton Pipkin, F, Craven, DJ. Changes in the renin-angiotensin system in primigravidae with hypertensive disease of pregnancy. Br J Obstet Gynaecol 1975; 82: 643–50.CrossRefGoogle ScholarPubMed
48 Brown, MA, Nicholson, E, Gallery, EDM. Sodium-renin-aldosterone relations in normal and hypertensive pregnancy. Br J Obstet Gynaecol 1988; 95: 1237–46.CrossRefGoogle ScholarPubMed
49 Brown, MA, Nicholson, E, Ross, MR, Norton, HE, Gallery, EDM. Progressive resetting of sodium-renin-aldosterone relationships in human pregnancy. Clin Exper Hyper 1987; B5: 349–74.Google Scholar
50 Weir, RJ, Brown, JJ, Fraser, R et al. Relationship between plasma renin, renin-substrate, angiotensin II, aldosterone and electrolytes in normal pregnancy. J Clin Endocrinol Metab 1975; 40: 108–15.CrossRefGoogle Scholar
51 Carr, BR, Gant, NF. The endocrinology of pregnancy-induced hypertension. Clinics Perinatology 1983; 10: 737–61.CrossRefGoogle ScholarPubMed
52 Friedman, SA. Preeclampsia: a review of the role of prostaglandins. Obstet Gynecol 1988; 71: 122–37.Google ScholarPubMed
53 Broughton Pipkin, F, Oats, JJN, Symonds, EM. Sequential changes in the human renin-angiotensin system following delivery. Br J Obstet Gynaecol 1978; 85: 821–27.CrossRefGoogle ScholarPubMed
54 Johnson, J, Johnson, IR, Ronan, JE, Craven, DJ. The site of renin in the human uterus. Histopathology 1984; 8: 273–78.CrossRefGoogle ScholarPubMed
55 Craven, DJ, Warren, AY, Symonds, EM. Generation of angiotensin I by tissues of the human female genital tract. Am J Obstet Gynecol 1983; 145: 749–51.CrossRefGoogle ScholarPubMed
56 Ihara, Y, Tais, S, Mori, T. Expression of renin and angiotensinogen genes in the human placental tissues. EndocrinolJapon 1987; 34: 887–96.Google ScholarPubMed
57 Coghlan, JP, Blair-West, JR. Aldosterone. In: Gray, CH, Bacharach, Al eds, Hormones in blood, volume 2. London: Academic Press, 1967: 391–488.Google Scholar
58 Karlberg, BE, Ryden, G, Wichman, K. Changes in the renin-angiotensin-aldosterone and kallikrein-kinin systems during normal and hypertensive pregnancy. Ada Obstet Gynecol Scand 1984; 118 (Suppl. 1): 17–24.CrossRefGoogle ScholarPubMed
59 Hsueh, WA, Luetscher, JA, Carlson, EJ, Grislis, G, Frazer, E, McHargue, A. Changes in active and inactive renin throughout pregnancy. J Clin Endocrinol Metab 1982; 54: 1010–16.CrossRefGoogle ScholarPubMed
60 Sealey, JE, Wilson, M, Morganti, AA, Zervoudakis, I, Laragh, JH. Changes in active and inactive renin throughout normal pregnancy. Clin Exper Hyper 1982; A4: 2373–84.Google Scholar
61 Wilson, M, Morganti, AA, Zervoudakis, I et al. Blood pressure, the renin-aldosterone system and sex steroids throughout normal pregnancy. Am J Med 1980; 68: 97–104.CrossRefGoogle ScholarPubMed
62 Brown, MA, Broughton Pipkin, F, Symonds, EM. The effects of intravenous angiotensin II upon blood pressure and sodium and urate excretion in human pregnancy. J Hypert 1988; 6: 457–64.CrossRefGoogle ScholarPubMed
63 Valloton, MB, Davison, JM, Riondel, AM, Lindheimer, MD. Response of the renin-aldosterone system and antidiuretic hormone to oral water loading and hypertonic saline infusion during and after pregnancy. Clin Exper Hyper 1982; B1: 385–400.Google Scholar
64 Weinberger, MH, Kramer, NJ, Petersen, LP, Cleary, RE, Young, PCM. Sequential changes in the renin-angiotensin-aldosterone systems and plasma progesterone concentration in normal and abnormal human pregnancy. In: Lindheimer, MD, Katz, Al, Zuspan, FP eds, Hypertension in pregnancy. New York: J Wiley & Sons, 1976: 263–69.Google Scholar
65 Oparil, S, Ehrlich, EN, Lindheimer, MD. Effect of progesterone on renal sodium handling in man: relation to aldosterone excretion and plasma renin activity. Clin Sci Mol Med 1975; 49: 139–47.Google ScholarPubMed
66 Sharp, GW, Komack, CL, Leaf, A. Studies of the binding of aldosterone in toad bladder. J Clin Invest 1966; 45: 450–59.CrossRefGoogle ScholarPubMed
67 Laidlaw, JC, Ruse, JL, Gornall, AG. The influence of estrogen and progesterone on aldosterone excretion. J Clin Endocrinol Metab 1962; 22: 161–71.CrossRefGoogle ScholarPubMed
68 Watanabe, M, Meeker, CI, Gray, MJ, Sims, EAH, Solomon, S. Aldosterone secretion rates in abnormal pregnancy. J Clin Endocrinol Metab 1965; 25: 1665–70.CrossRefGoogle ScholarPubMed
69 Simpson, ER, MacDonald, PC. Endocrinology of pregnancy. In: Williams, RH ed, Textbook of endocrinology, sixth edition. Philadelphia: WB Saunders, 1981: 415–16.Google Scholar
70 Smeaton, TC, Anderson, GJ, Fulton, IS. Study of aldosterone levels in plasma during pregnancy. J Clin Endocrinol Metab 1977; 44: 1–7.CrossRefGoogle ScholarPubMed
71 Brown, MA, Sinosich, MJ, Saunders, DM, Gallery, EDM. Potassium regulation and progesterone-aldosterone interrelationships in human pregnancy: a prospective study. Am J Obstet Gynecol 1986; 155: 349–53.CrossRefGoogle ScholarPubMed
72 Glance, DG, Elder, MG, Bloxem, DL, Myett, L. The effects of the components of the renin-angiotensin system on the isolated perfused human placental cotyledon. Am J Obstet Gynecol 1984; 149: 450–54.CrossRefGoogle ScholarPubMed
73 Broughton Pipkin, F, Hunter, JC, Turner, SR, O'Brien, PMS. The effect of prostaglandin E2 upon the biochemical response to infused angiotensin II in human pregnancy. Clin Sci 1984; 66: 399–406.CrossRefGoogle ScholarPubMed
74 Chesley, LC, Wynn, RM, Silverman, NI. Renal effects of angiotensin II infusions in normotensive pregnant and nonpregnant women. Circ Res 1963; 13: 232–38.CrossRefGoogle ScholarPubMed
75 Levenson, DJ, Simmons, CE, Brenner, BM. Arachidonic acid metabolism, prostaglandins and the kidney. Am J Med 1982; 72: 354–74.CrossRefGoogle ScholarPubMed
76 Patrono, C, Pugliese, F, Ciabattoni, G et al. Evidence for a direct stimulatory effect of prostacyclin on renin release in man. J Clin Invest 1982; 69: 231–39.CrossRefGoogle ScholarPubMed
77 Simpson, FO. Sodium intake, body sodium, and sodium excretion. Lancet 1988; ii: 25–29.CrossRefGoogle Scholar
78 Brown, JJ, Davies, DL, Doak, PB, Lever, AF, Robertson, JIS. Plasma renin concentration in the hypertensive diseases of pregnancy. Br J Obstet Gynaecol 1966; 73: 410–17.CrossRefGoogle ScholarPubMed
79 Weir, RJ, Brown, JJ, Frazer, R et al. Plasma renin, renin substrate, angiotensin II and aldosterone in hypertensive disease of pregnancy. Lancet 1973; i: 291–94.CrossRefGoogle Scholar
80 Symonds, EM, Anderson, GJ. The effect of bed rest on plasma renin in hypertensive disease of pregnancy. J Obstet Gynaecol Br Commonwlth 1974; 81: 676–81.CrossRefGoogle ScholarPubMed
81 Brar, HS, Kjos, SL, Dougherty, W, Do, YS, Tam, HB, Hsueh, WA. Increased fetoplacental active renin production in pregnancy-induced hypertension. Am J Obstet Gynecol 1987; 157: 363–67.CrossRefGoogle ScholarPubMed
82 Gallery, EDM, Stokes, GS, Gyory, AZ, Rowe, J, Williams, J. Plasma renin activity in normal human pregnancy and in pregnancy-associated hypertension, with reference to cryoactivation. Clin Sci 1980; 59: 49–53.CrossRefGoogle ScholarPubMed
83 Ambroso, GC, Morganti, A, Como, G, Masa, A, Candiani, GB, Polvani, F. Active and inactive renin throughout high risk pregnancy. Clin Exper Hyper 1988; B7: 75–88.Google Scholar
84 Lindberg, BS, Nilsson, BA, Johansson, EDB. Plasma progesterone levels in normal and abnormal pregnancies. Acta Obstet Gynecol Scand 1974; 53: 329–35.CrossRefGoogle ScholarPubMed
85 Kokot, F, Cekanski, A. Plasma renin activity in peripheral and uterine vein blood in pregnant and nonpregnant women. J Obstet Gynaecol Br Commonwlth 1972; 79: 72–76.CrossRefGoogle Scholar
86 Fievet, P, Pleskov, L, Desailly, I et al. Plasma renin activity, blood uric acid and plasma volume in pregnancy-induced hypertension. Proc EDTA 1983; 20: 520–29.Google ScholarPubMed
87 Nicholson, EC, Gallery, EDM, Brown, MA, Ross, MR, Jones, M. Renin activation in normal and hypertensive human pregnancy. Clin Exper Hyper 1988; B6: 453–64.Google Scholar
88 Taufield, PA, Druzin, ML, Edersheim, TE, Sealey, JE, Laragh, JH. Correlation between plasma renin activity and birth weight in hypertensive pregnancy. J Hypert 1986; 4 (Suppl. 5): S96–98.Google ScholarPubMed
89 Nochy, D, Bariety, J, Camilleri, JP, Barres, D, Corvol, P, Menard, J. Diminished number of renin containing cells in kidney biopsy samples from hypertensive women immediately post-partum: an immunomorphologic study. Kidney Int 1984; 26: 85–87.CrossRefGoogle ScholarPubMed
90 Fievet, P, Gregoire, I, Agnes, E et al. Renin-angiotensin-aldosterone system, urinary prostaglandins and kallikrein in pregnancy-induced hypertension: evidence for a dysregulation of the renin-angiotensin-prostacyclin loop. J Hypert 1986; 4 (Suppl. 5): S88–91.Google ScholarPubMed
91 Maack, T, Camargo, MJF, Kleinert, HD, Laragh, JH, Atlas, SA. Atrial natriuretic factor: structures and functional properties. Kidney Int 1985; 27: 607–15.CrossRefGoogle Scholar
92 Trippodo, NC. An update on the physiology of atrial natriuretic factor. Hypertension 1987; 10: 1122–127.CrossRefGoogle ScholarPubMed
93 Thomsen, JK, Storm, TL, Thamsborg, G, de Nully, M, Bodker, B, Skouby, SO. Increased concentration of circulating atrial natriuretic peptide during normal pregnancy. Eur J Obstet Gynecol Reprod Biol 1988; 27: 197–201.CrossRefGoogle ScholarPubMed
94 Otsuki, Y, Okamoto, E, Iwata, I, Nishino, E, Tanizawa, O. Plasma hANP concentrations during pregnancy including PIH and around the delivery. Sixth International Congress ISSHP, 1988: 26: (abstract).Google Scholar
95 Miyamoto, S, Shimokawa, H, Sumioki, H et al. Circadian rhythm of plasma ANP, aldosterone and blood pressure during the third trimester in normal and preeclamptic pregnancies. Am J Obstet Gynecol 1988; 158: 393–99.CrossRefGoogle Scholar
96 Doniec Ulman, I, Wambach, KG, Drab, M. Water immersion induced endocrine alterations in women with EPH gestosis. Clin Nephrol 1987; 28: 51–55.Google ScholarPubMed
97 Shrivastav, P, Gill, DS, D'Souza, V, O'Brien, PMS, Dandona, P. Secretion of atrial natriuretic peptide and digoxin-like immunoreactive substance during pregnancy. Clin Chem 1988; 34: 977–80.CrossRefGoogle ScholarPubMed
98 Hirai, N, Yandihara, T, Nakayama, T, Ishibashi, M, Yamaji, T. Plasma levels of atrial natriuretic peptide during normal pregnancy and in pregnancy complicated by hypertension. Am J Obstet Gynecol 1988; 159: 27–31.CrossRefGoogle ScholarPubMed
99 Di Lieto, A, Campanile, M, Paladini, D, Albano, G, Paladini, A. Atrial natriuretic peptide and the renin angiotensin aldosterone system in normotensive and hypertensive pregnancy. Clin Exper Hyper 1988; B7: 89–97.Google Scholar
100 Jackson, B, Hodsman, GP, Allen, PS, Johnson, CI. Atrial natriuretic factor: plasma concentrations in normal pregnancy. Kidney Int 1988; 33: 140 (abstract).Google Scholar
101 Stratta, P, Canavese, C, Gurioli, L et al. Atrial natriuretic factor as a marker of the intravascular volume conditions in normal and hypertensive pregnancies. Clin Exper Hyper 1988; 7: 107–11.Google Scholar
102 Steegers, EAP, Derky, FHM, Benraad, TJ, Schalekamp, MADH, de Bruin, R, Hein, PR. Effects of short term dietary sodium restriction on the renin-aldosterone system and atrial natriuretic peptide in normal pregnancy. Sixth International Congress ISSHP, 1988: 23 (abstract).Google Scholar
103 Mizutori, M, Morikawa, H, Yamasaki, M, Mimura, O, Inui, M, Mochizuki, M. The changes in human atrial natriuretic polypeptide after loading tests performed in pregnancy-induced hypertension. Sixth International Congress ISSHP, 1988: 19 (abstract).Google Scholar
104 Niesert, S, Kaulhausen, H. Atrial natriuretic peptide (ANP) during pregnancy. Clin Exper Hyper 1988; B7: 99–105.Google Scholar
105 Fievet, P, Fournier, A, de Bold, A et al. Atrial natriuretic factor in pregnancy-induced hypertension and preeclampsia: increased plasma concentrations possibly explaining these hypovolemic states with paradoxical hyporeninism. Am J Hypert 1988; 1: 16–21.CrossRefGoogle ScholarPubMed
106 Visser, W, Derkx, F, Makovitz, J et al. Cardiac production of natriuretic peptide in preeclampsia. Sixth International Congress ISSHP, 1988: 3.Google Scholar
107 Brown, MA, Zammit, VC, Lowe, SA. Capillary permeability and extracellular fluid volumes in normal pregnancy induced hypertension. Clin Sci (in press).Google Scholar
108 Doucet, A. Function and control of Na+-K+-ATPase in single nephron segments of the mammalian kidney. Kidney Int 1988; 34: 749–60.CrossRefGoogle Scholar
109 de Wardener, HE, MacGregor, GA. The relation of a circulating sodium transport inhibitor (the natriuretic hormone?) to hypertension. Medicine 1983; 62: 310–26.CrossRefGoogle ScholarPubMed
110 Weisberg, PL, Weaver, J, Woods, KL, West, MJ, Beevers, DG. Pregnancy induced hypertension: evidence for increased cell membrane permeability to sodium. Br Med J 1983; 287: 709–11.CrossRefGoogle Scholar
111 Rubython, J, Morgan, DB. The effect of pregnancy and pregnancy induced hypertension on active sodium transport in the erythrocyte. Clin Chem Ada 1983; 132: 91–99.CrossRefGoogle ScholarPubMed
112 Gudson, JP Jr, Buckalew, VM Jr, Hennessy, JF. A digoxin-like immunoreactive substance in preeclampsia. Am J Obstet Gynecol 1984; 150: 83–85.Google Scholar
113 Friedman, HS, Abramowitz, I, Nguyen, T et al. Urinary digoxin-like immunoreactive substance in pregnancy. Am J Med 1987; 83: 261–64.CrossRefGoogle ScholarPubMed
114 Graves, SW, Williams, GH. An endogenous ouabain-like factor associated with hypertensive pregnant women. J Clin Endocrinol Metab 1984; 59: 1070–74.CrossRefGoogle ScholarPubMed
115 Longerich, L, Brent, DA, Johnson, RL, Vasdev, S, Gault, MH. Identification of progesterone and cortisol as immunoreactive plasma digitalis like factors in pregnancy. Res Comm Chem Path Pharm 1988; 59: 383–93.Google ScholarPubMed
116 Gonzales, AR, Phelps, JJ, Cochran, EB, Sibai, BM. Digoxin-like immunoreactive substance in pregnancy. Am J Obstet Gynecol 1987; 157: 660–64.CrossRefGoogle Scholar
117 Gallery, EDM, Rowe, J, Brown, MA, Ross, M. Effect of changes in dietary sodium on active electrolyte transport by erythrocytes at different stages of human pregnancy. Clin Sci 1988; 74: 145–50.CrossRefGoogle ScholarPubMed
118 Gallery, EDM, Esber, RP, Brown, MA, Hawkins, MR, Ross, M. Alterations in erythrocyte Na+-K+-cotransport in normal and hypertensive human pregnancy. J Hypert 1988; 6: 153–58.CrossRefGoogle Scholar
119 Blaustein, MP, Hamlyn, JM. Sodium transport inhibition, cell calcium and hypertension. Am J Med 1984; 77(4A): 45–59.CrossRefGoogle ScholarPubMed
120 Hamlyn, JM, Blaustein, MP. Sodium chloride, extracellular fluid volume, and blood pressure regulation. AmJ Physiol 1986; 251: F563–75.Google ScholarPubMed
121 Gregoire, I, Roth, D, Siegenthaler, G et al. A ouabain-displacing factor in normal pregnancy, pregnancy-induced hypertension and pre-eclampsia. Clin Sci 1988; 74: 307–10.CrossRefGoogle ScholarPubMed
122 Gallery, EDM, Delprado, W, Györy, AZ. Antihypertensive effect of plasma volume expansion in pregnancy-associated hypertension. Aust NZ J Med 1981; 11: 20–24.Google ScholarPubMed