Cerebral Palsy (CP) describes a group of permanent non progressive but often changing neurological impairement syndromes as assessed at 3 and 5 years of age. The term includes serious motor disorders including spastic diplegia (Little syndrome), hemiplegia and quadriplegia associated with neuropsychological seizures and cognitive impairment due to permanent damage to the immature brain. Fifty percent of CP cases are premature neonates and 25% are very severely premature. There is a significant correlation between CP and brain lesions in the neonatal period among which periventricular leukomalacia (PVL) is the most common.