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MANAGEMENT CONUNDRUMS IN MULTIPLE PREGNANCIES WITH SELECTIVE REDUCTION, INTRAUTERINE FETAL DEATH OR SPONTANEOUS ABORTION

Published online by Cambridge University Press:  01 August 2009

RITU MOGRA
Affiliation:
Royal Prince Alfred Hospital, University of Sydney, Sydney, New South Wales, Australia.
DAVID LH MOORE
Affiliation:
Gold Coast Hospital, Southport, Queensland, Australia
JON A HYETT*
Affiliation:
Royal Prince Alfred Hospital, University of Sydney, Sydney, New South Wales, Australia.
*
Dr Jon Hyett, Head of High Risk Obstetrics, RPA Women and Babies, Royal Prince Alfred Hospital, Missenden Road, Sydney 2050, Australia.

Extract

There has been a marked increase in the prevalence of twins, triplets and higher-order multiple pregnancies over the last 20 years due, in part, to delayed childbearing, but more significantly associated with the widespread introduction of assisted reproductive techniques. Once viability is confirmed these pregnancies pose a series of unique challenges to the obstetrician as the dynamic of the maternal – fetal relationship changes when there are two, or more, fetuses to consider. With the exception of postmaturity, all obstetric complications are more common in multiple pregnancies. Australian data shows perinatal mortality rates of 7, 25 and 63 per 1,000 births for singleton, twin (RR 3.4) and triplet (RR 8.5) pregnancies respectively; with similar rates reported in the UK and USA. While multiple pregnancies account for only 2% of births, they account for 20% of neonatal admissions and 12% of perinatal deaths – with a 5-fold increase in deaths before 1 year of age.

Type
Research Article
Copyright
Copyright © Cambridge University Press 2009

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References

REFERENCES

1Eriksson, AW, Fellman, J. Temporal trends in the rates of multiple maternities in England and Wales. Twin Res Hum Genet 2007; 10: 626–32.CrossRefGoogle ScholarPubMed
2Laws, P, Abeywardana, S, Walker, J, Sullivan, E. Australia's mothers and babies 2005. Sydney: AIHW National Perinatal Statistics Unit; 2007.Google Scholar
3Confidential Enquiry into Maternal and Child Health. Perinatal mortality 2005: England, Wales and Northern Ireland. London: CEMACH; 2007.Google Scholar
4MacDorman, MF, Hoyert, DL, Martin, JA, Munson, M, Hamilton, BE. Fetal and Perinatal Mortality, United States, 2003 Hyattsville: National Centre for Health Statistics; 2007.Google Scholar
5Petterson, B, Nelson, KB, Watson, L, Stanley, F. Twins, triplets, and cerebral palsy in births in Western Australia in the 1980s. Br Med J 1993; 307: 1239–243.CrossRefGoogle ScholarPubMed
6Hack, KE, Derks, JB, Elias, SG, Franx, A, Roos, EJ, Voerman, SK, et al. Increased perinatal mortality and morbidity in monochorionic versus dichorionic twin pregnancies: clinical implications of a large Dutch cohort study. BJOG 2008; 115: 5867.CrossRefGoogle ScholarPubMed
7Geipel, A, Berg, C, Katalinic, A, Ludwig, M, Germer, U, Diedrich, K, et al. Different preferences for prenatal diagnosis in pregnancies following assisted reproduction versus spontaneous conception. Reprod Biomed Online 2004; 8: 119–24.CrossRefGoogle ScholarPubMed
8Holmes, A, Jauniaux, E. Prospective study of parental choice for aneuploidy screening in assisted conception versus spontaneously conceived twins. Reprod Biomed Online 2004; 8: 243–45.CrossRefGoogle ScholarPubMed
9Sebire, NJ, Snijders, RJ, Hughes, K, Sepulveda, W, Nicolaides, KH. The hidden mortality of monochorionic twin pregnancies. Br J Obstet Gynaecol 1997; 104: 1203–207.CrossRefGoogle ScholarPubMed
10Sperling, L, Kiil, C, Larsen, LU, Qvist, I, Schwartz, M, Jorgensen, C, et al. Naturally conceived twins with monochorionic placentation have the highest risk of fetal loss. Ultrasound Obstet Gynecol 2006; 28: 644–52.CrossRefGoogle ScholarPubMed
11Sampson, A, de Crespigny, LC. Vanishing twins: the frequency of spontaneous fetal reduction of a twin pregnancy. Ultrasound Obstet Gynecol 1992; 2: 107109.CrossRefGoogle ScholarPubMed
12Landy, HJ, Weiner, S, Corson, SL, Batzer, FR, Bolognese, RJ. The “vanishing twin”: ultrasonographic assessment of fetal disappearance in the first trimester. Am J Obstet Gynecol 1986; 155: 1419.CrossRefGoogle ScholarPubMed
13Samuels, P. Ultrasound in the management of the twin gestation. Clin Obstet Gynecol 1988; 31: 110–22.CrossRefGoogle ScholarPubMed
14Weiss, JL, Cleary-Goldman, J, Tanji, K, Budorick, N, D'Alton, ME. Multicystic encephalomalacia after first-trimester intrauterine fetal death in monochorionic twins. Am J Obstet Gynecol 2004; 190: 563–65.CrossRefGoogle ScholarPubMed
15Chasen, ST, Perni, SC, Predanic, M, Kalish, RB, Chervenak, FA. Does a “vanishing twin” affect first-trimester biochemistry in Down syndrome risk assessment? Am J Obstet Gynecol 2006; 195: 236–39.CrossRefGoogle Scholar
16Gjerris, AC, Loft, A, Pinborg, A, Christiansen, M, Tabor, A. The effect of a ‘vanishing twin’ on biochemical and ultrasound first trimester screening markers for Down's syndrome in pregnancies conceived by assisted reproductive technology. Hum Reprod 2009; 24: 5562.CrossRefGoogle ScholarPubMed
17Hellin, D. Die ursache der multiparitat der uniparen. Tiere uberhaupt und der zwillingsschwangerschaft beim menshen insbesondere. Munchen: Seitz & Schauer. 1895; 70.Google Scholar
18Umstad, MP, Gronow, MJ. Multiple pregnancy: a modern epidemic? Med J Australia 2003; 178: 613615.CrossRefGoogle ScholarPubMed
19Evans, MI, Ciorica, D, Britt, DW, Fletcher, JC. Update on selective reduction. Prenat Diagn 2005; 25: 807–13.CrossRefGoogle ScholarPubMed
20Strauss, A, Paek, BW, Genzel-Boroviczeny, O, Schulze, A, Janssen, U, Hepp, H. Multifetal gestation – maternal and perinatal outcome of 112 pregnancies. Fetal Diagn Ther 2002; 17: 209–17.CrossRefGoogle ScholarPubMed
21Elliott, JP. Management of high-order multiple gestation. Clin Perinatol 2005; 32: 387402.CrossRefGoogle ScholarPubMed
22Rand, L, Eddleman, KA, Stone, J. Long-term outcomes in multiple gestations. Clin Perinatol 2005; 32: 495513.CrossRefGoogle ScholarPubMed
23JOINT, SOGC-CFAS. Guidelines for the number of embryos to transfer following in vitro fertilization No. 182, September 2006. Int J Gynaecol Obstet 2008; 102: 203216.Google Scholar
24Dumez, Y, Oury, JF. Method for first trimester selective abortion in multiple pregnancy. Contrib Gynecol Obstet 1986; 15: 5053.CrossRefGoogle ScholarPubMed
25Evans, MI, Fletcher, JC, Zador, IE, Newton, BW, Sturyk, CK, Quigg, MH. Selective first trimester termination in octuplet and quadruplet pregnancies: clinical and ethical issues. Obstet Gynecol 1988; 71: 289–96.Google ScholarPubMed
26Berkowitz, RL, Lynch, L, Chitkara, U et al. Selective reduction of multiple pregnancies in the first trimester of pregnancy. N Engl J Med 1998; 318: 1043.CrossRefGoogle Scholar
27Timor-Tritsch, IE, Bashiri, A, Monteagudo, A, Rebarber, A, Arslan, AA. Two hundred ninety consecutive cases of multifetal pregnancy reduction: Comparison of the transabdominal versus the transvaginal approach. Am J Obstet Gynecol 2004; 191: 20852089.CrossRefGoogle ScholarPubMed
28Evans, MI, Dommergues, M, Wapner, RJ, Lynch, L, Dumez, Y, Goldberg, JD et al. Efficacy of transabdominal multifetal pregnancy reduction: collaborative experience among the world's largest centres. Obstet Gynecol 1993; 82: 6167.Google Scholar
29Evans, MI, Berkowitz, RL, Wapner, RJ, Carpenter, RJ, Goldberg, JD, Ayoub, MA, et al. Improvement in outcomes of multifetal pregnancy reduction with increased experience. Am J Obstet Gynecol 2001; 184: 97103.CrossRefGoogle ScholarPubMed
30Evans, MI, Johnson, MP, Quintero, RA, Fletcher, JC. Ethical issues surrounding multifetal pregnancy reduction and selective termination. Clin Perinatol 1996; 23: 437–51.CrossRefGoogle ScholarPubMed
31Yaron, Y, Bryant-Greenwood, PK, Dave, N, Moldenhauer, JS, Kramer, RL, Johnson, MP et al. Multifetal pregnancy reduction (MFPR) of triplets to twins: comparison with non-reduced triplets and twins. Am J Obstet Gynecol 1999; 180: 1268–271.CrossRefGoogle Scholar
32Leondires, MP, Ernst, SD, Miller, BT et al. Triplets: outcomes of expectant management versus multifetal reduction for 127 pregnancies. Am J Obstet Gynecol 1999; 72: 257–60.Google Scholar
33Stone, J, Belogolovkin, V, Matho, A, Berkowitz, RL, Moshier, E. Evolving trends in 2000 cases of multifetal pregnancy reduction: a single-centre experience. Am J Obstet Gynecol 2007; 197: 394.e1–4.CrossRefGoogle Scholar
34Papageorghiou, AT, Avgidou, K, bakoulas, V, Sebire, NJ, Nicolaides, KH. Risks of miscarriage and early preterm birth in trichorionic triplet pregnancies with embryo reduction versus expectant management: new data and systematic review. Human Reprod 2006; 21: 1912–917.CrossRefGoogle ScholarPubMed
35De Catte, L, Foulon, W. Obstetric outcome after fetal reduction to singleton pregnancies. Prenat Diagn 2002; 22: 206–10.CrossRefGoogle ScholarPubMed
36Stone, J, Ferrara, L, Kamrath, J, Getrajdman, J, Berkowitz, R, Moshier, E et al. Contemporary outcome with the latest 1000 cases of multifetal pregnancy reduction (MPR). Am J Obstet Gynecol 2008; 199: 406e1–4CrossRefGoogle ScholarPubMed
37Meyers, C, Adam, R, Dungan, J, Prenger, V. Aneuploidy in twin gestations: when is maternal age advanced? Obstet Gynecol 1997; 89: 248–51.CrossRefGoogle ScholarPubMed
38Mastroiacovo, P, Castilla, EE, Arpino, C, Botting, B, Cocchi, G, Goujard, J et al. Congenital malformations in twins: an international study. Am J Med Genet 1999; 83: 117–24.3.0.CO;2-4>CrossRefGoogle ScholarPubMed
39Machin, G. Placentation in multiple births. Twin Res 2001; 4: 150–55.CrossRefGoogle ScholarPubMed
40Spencer, K, Nicolaides, KH. Screening for trisomy 21 in twins using first trimester ultrasound and maternal serum biochemistry in a one-stop clinic: a review of three years experience. BJOG 2003; 110: 276–80.Google Scholar
41Sebire, NJ, D'Ercole, C, Hughes, K, Carvalho, M, Nicolaides, KH. Increased nuchal translucency thickness at 10–14 weeks of gestation as a predictor of severe twin-to-twin transfusion syndrome. Ultrasound Obstet Gynecol 1997; 10: 86–9.CrossRefGoogle ScholarPubMed
42Sebire, NJ, Snijders, RJ, Hughes, K, Sepulveda, W, Nicolaides, KH. Screening for trisomy 21 in twin pregnancies by maternal age and fetal nuchal translucency thickness at 10–14 weeks of gestation. Br J Obstet Gynaecol 1996; 103: 9991003.CrossRefGoogle ScholarPubMed
43Kagan, KO, Gazzoni, A, Sepulveda-Gonzalez, G, Sotiriadis, A, Nicolaides, KH. Discordance in nuchal translucency thickness in the prediction of severe twin-to-twin transfusion syndrome. Ultrasound Obstet Gynecol 2007; 29: 527–32.CrossRefGoogle ScholarPubMed
44Vandecruys, H, Faiola, S, Auer, M, Sebire, N, Nicolaides, KH. Screening for trisomy 21 in monochorionic twins by measurement of fetal nuchal translucency thickness. Ultrasound Obstet Gynecol 2005; 25: 551–53.CrossRefGoogle ScholarPubMed
45Rodis, JF, Egan, JF, Craffey, A, Ciarleglio, L, Greenstein, RM, Scorza, WE. Calculated risk of chromosomal abnormalities in twin gestations. Obstet Gynecol 1990; 76: 1037–41.Google ScholarPubMed
46Lewi, L, Blickstein, I, Van Schoubroeck, D, Gloning, KP, Casteels, M, Brandenburg, H, et al. Diagnosis and management of heterokaryotypic monochorionic twins. Am J Med Genet A 2006; 140: 272–75.CrossRefGoogle ScholarPubMed
47Rogers, JG, Voullaire, L, Gold, H. Monozygotic twins discordant for trisomy 21. Am J Med Genet 1982; 11: 143–46.CrossRefGoogle ScholarPubMed
48Nieuwint, A, Van Zalen-Sprock, R, Hummel, P, Pals, G, Van Vugt, J, Van Der Harten, H et al. ‘Identical’ twins with discordant karyotypes. Prenat Diagn 1999; 19: 7276.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
49Evans, MI, Goldberg, JD, Horenstein, J, Wapner, RJ, Ayoub, MA, Stone, J, et al. Selective termination for structural, chromosomal, and Mendelian anomalies: International experience. Am J Obstet Gynecol 1999; 181: 893–97.CrossRefGoogle ScholarPubMed
50Sebire, NJ, Noble, PL, Psarra, A, Papapanagiotou, G, Nicolaides, KH. Fetal karyotyping in twin pregnancies: selection of technique by measurement of fetal nuchal translucency. Br J Obstet Gynaecol 1996; 103: 887–90.CrossRefGoogle ScholarPubMed
51Brambati, B, Tului, L, Guercilena, S, Alberti, E. Outcome of first-trimester chorionic villus sampling for genetic investigation in multiple pregnancy. Ultrasound Obstet Gynecol 2001; 17: 209–16.CrossRefGoogle ScholarPubMed
52Yukobowich, E, Anteby, EY, Cohen, SM, Lavy, Y, Granat, M, Yagel, S. Risk of fetal loss in twin pregnancies undergoing second trimester amniocentesis. Obstet Gynecol 2001; 98: 231–34.Google ScholarPubMed
53Millaire, M, Bujold, E, Morency, AM, Gauthier, RJ. Mid-trimester genetic amniocentesis in twin pregnancy and the risk of fetal loss. J Obstet Gynaecol Can 2006; 28: 512–18.CrossRefGoogle ScholarPubMed
54Taylor, MJ, Fisk, NM. Prenatal diagnosis in multiple pregnancy. Baillieres Best Pract Res Clin Obstet Gynaecol 2000; 14: 663–75.CrossRefGoogle ScholarPubMed
55Weisz, B, Rodeck, CH. Invasive diagnostic procedures in twin pregnancies. Prenat Diagn 2005; 25: 751–58.CrossRefGoogle ScholarPubMed
56Saltvedt, S, Almström, H, Kublickas, M, Valentin, L, Grunewald, C. Detection of malformations in chromosomally normal fetuses by routine ultrasound at 12 or 18 weeks of gestation-a randomised controlled trial in 39,572 pregnancies. BJOG 2006; 113: 664–74.CrossRefGoogle ScholarPubMed
57Li, SJ, Ford, N, Meister, K, Bodurtha, J. Increased risk of birth defects among children from multiple births. Birth Defects Res A Clin Mol Teratol 2003; 67: 879–85.CrossRefGoogle ScholarPubMed
58Hall, JG. Twinning. Lancet 2003; 362: 735–43.CrossRefGoogle ScholarPubMed
59Schinzel, AA, Smith, DW, Miller, JR. Monozygotic twinning and structural defects. J Pediatr 1979; 95: 921–30.CrossRefGoogle ScholarPubMed
60Hoyme, HE, Higginbottom, MC, Jones, KL. Vascular etiology of disruptive structural defects in monozygotic twins. Pediatrics 1981; 67: 288–91.CrossRefGoogle ScholarPubMed
61Tai, J, Grobman, WA. The association of crown-rump length discordance in twin gestations with adverse perinatal outcomes. Am J Obstet Gynecol 2007; 197: 369 e14.CrossRefGoogle ScholarPubMed
62Malone, FD, Craigo, SD, Chelmow, D, D'Alton, ME. Outcome of twin gestations complicated by a single anomalous fetus. Obstet Gynecol 1996; 88: 15.CrossRefGoogle ScholarPubMed
63Nassar, AH, Adra, AM, Gomez-Marin, O, O'Sullivan, MJ. Perinatal outcome of twin pregnancies with one structurally affected fetus: a case-control study. J Perinatol 2000; 20: 8286.CrossRefGoogle ScholarPubMed
64Ong, SS, Zamora, J, Khan, KS, Kilby, MD. Prognosis for the co-twin following single-twin death: a systematic review. BJOG 2006; 113: 992–98.CrossRefGoogle ScholarPubMed
65Bajoria, R, Wee, LY, Anwar, S, Ward, S. Outcome of twin pregnancies complicated by single intrauterine death in relation to vascular anatomy of the monochorionic placenta. Hum Reprod 1999; 14: 2124–130.CrossRefGoogle ScholarPubMed
66Nicolini, U, Poblete, A. Single intrauterine death in monochorionic twin pregnancies. Ultrasound Obstet Gynecol 1999; 14: 297301.CrossRefGoogle ScholarPubMed
67Vandecruys, H, Avgidou, K, Surerus, E, Flack, N, Nicolaides, KH. Dilemmas in the management of twins discordant for anencephaly diagnosed at 11 + 0 to 13 + 6 weeks of gestation. Ultrasound Obstet Gynecol 2006; 28: 653–58.CrossRefGoogle Scholar
68Lust, A, De Catte, L, Lewi, L, Deprest, J, Loquet, P, Devlieger, R. Monochorionic and dichorionic twin pregnancies discordant for fetal anencephaly: a systematic review of prenatal management options. Prenat Diagn 2008; 28: 275–79.CrossRefGoogle ScholarPubMed
69Ville, Y. Selective feticide in monochorionic pregnancies: toys for the boys or standard of care? Ultrasound Obstet Gynecol 2003; 22: 448–50.CrossRefGoogle ScholarPubMed
70Ville, Y, Hyett, JA, Vandenbussche, FP, Nicolaides, KH. Endoscopic laser coagulation of umbilical cord vessels in twin reversed arterial perfusion sequence. Ultrasound Obstet Gynecol 1994; 4: 396–98.CrossRefGoogle ScholarPubMed
71Diehl, W, Hecher, K. Selective cord coagulation in acardiac twins. Semin Fetal Neonatal Med 2007; 12: 458–63.CrossRefGoogle ScholarPubMed
72Crombleholme, TM, Robertson, F, Marx, G, Yarnell, R, D'Alton, ME. Fetoscopic cord ligation to prevent neurological injury in monozygous twins. Lancet 1996; 348: 191.CrossRefGoogle ScholarPubMed
73Deprest, JA, Van Ballaer, PP, Everard, VA, Peers, KHE, Spitz, B, Steegers, EA et al. Experience with fetoscopic cord ligation. Eur J Obstet Gynecol Reprod Biol 1998; 81: 157–64.CrossRefGoogle ScholarPubMed
74Hecher, K, Lewi, L, Gratacos, E, Huber, A, Ville, Y, Deprest, J. Twin reversed arterial perfusion: fetoscopic laser coagulation of placental anastomoses or the umbilical cord. Ultrasound Obstet Gynecol 2006; 28: 688–91.CrossRefGoogle ScholarPubMed
75Tan, TY, Sepulveda, W. Acardiac twin: a systematic review of minimally invasive treatment modalities. Ultrasound Obstet Gynecol 2003; 22: 409–19.CrossRefGoogle ScholarPubMed
76Deprest, JA, Audibert, F, Van Schoubroeck, D, Hecher, K, Mahieu-Cauto, D. Bipolar coagulation of the umbilical cord in complicated monochorionic twin pregnancy. Am J Obstet Gynecol 2000; 182: 340–45.CrossRefGoogle ScholarPubMed
77Gallot, D, Laurichesse, H, Lemery, D. Selective feticide in monochorionic twin pregnancies by ultrasound-guided umbilical cord occlusion. Ultrasound Obstet Gynecol 2003; 22: 484–88.CrossRefGoogle ScholarPubMed
78Rustico, MA, Baietti, MG, Coviello, D, Orlandi, E, Nicolini, U. Managing twins discordant for fetal anomaly. Prenat Diagn 2005; 25: 766–71CrossRefGoogle ScholarPubMed
79Robyr, R, Yamamoto, M, Ville, Y. Selective feticide in complicated monochorionic twin pregnancies using ultrasound-guided bipolar cord coagulation. BJOG 2005; 112: 1344–348.CrossRefGoogle ScholarPubMed
80Lewi, L, Gratacós, E, Ortibus, E, Van Schoubroeck, D, Carreras, E, Higueras, T et al. Pregnancy and infant outcome of 80 consecutive cord coagulations in complicated monochorionic multiple pregnancies. Am J Obstet Gynecol 2006; 194: 782–89.CrossRefGoogle ScholarPubMed
81Moise, KJ, Johnson, A, Moise, KY, Nickeleit, V. Radiofrequency ablation for selective reduction in the complicated monochorionic gestation. Am J Obstet Gynecol 2008; 198: 198.e1–5.CrossRefGoogle ScholarPubMed
82Fisk, NM, Fordham, K, Abramsky, L. Elective late fetal karyotyping. Br J Obstet Gynaecol 1996; 103: 468–70.CrossRefGoogle ScholarPubMed
83Glinianaia, SV, Pharoah, PO, Wright, C, Rankin, JM, Northern Region Perinatal Mortality Survey Steering Group. Fetal or infant death in twin pregnancy: neurodevelopmental consequence for the survivor. Arch Dis Child Fetal Neonatal Ed 2002; 86: F9–15.CrossRefGoogle ScholarPubMed
84Hack, KE, Derks, JB, Elias, SG, Franx, A, Roos, EJ, Voerman, SK, Bode, CL, Koopman-Esseboom, C, Visser, GH. Increased perinatal mortality and morbidity in monochorionic versus dichorionic twin pregnancies: clinical implications of a large Dutch cohort study. BJOG 2008; 115: 5867.CrossRefGoogle ScholarPubMed
85Pritchard, JA, Ratnoff, OD. Studies of fibrinogen and other haemostatic factors in women with intrauterine death and delayed delivery. Surg Gynecol Obstet 1955; 101: 467–77.Google ScholarPubMed
86Tempfer, CB, Brunner, A, Bentz, EK, Langer, M, Reinthaller, A, Hefler, LA. Intrauterine fetal death and delivery complications associated with coagulopathy: a retrospective analysis of 104 cases. J Womens Health 2009; 18: 469–74.CrossRefGoogle ScholarPubMed
87Maslow, AD, Breen, TW, Sarna, MC, Soni, AK, Watkins, J, Oriol, NE. Prevalence of coagulation abnormalities associated with intrauterine fetal death. Can J Anaesth 1996; 43: 1237–243.CrossRefGoogle ScholarPubMed
88Woo, HH, Sin, SY, Tang, LC. Single foetal death in twin pregnancies: review of the maternal and neonatal outcomes and management. Hong Kong Med J 2000; 6: 293300.Google ScholarPubMed
89Kaufman, HK, Hume, RF Jr, Calhoun, BC, Carlson, N, Yorke, V, Elliott, D, Evans, MI. Natural history of twin gestation complicated by in utero fetal demise: associations of chorionicity, prematurity, and maternal morbidity. Fetal Diagn Ther 2003; 18: 442–46.CrossRefGoogle ScholarPubMed
90Benirschke, K. Intrauterine death of a twin: mechanisms, implications for surviving twin, and placental pathology. Semin Diagn Pathol 1993; 10: 222–31.Google ScholarPubMed
91Denbow, ML, Cox, P, Taylor, M, Hammal, DM, Fisk, NM. Placental angioarchitecture in monochorionic twin pregnancies: relationship to fetal growth, fetofetal transfusion syndrome, and pregnancy outcome. Am J Obstet Gynecol 2000; 182: 417–26.CrossRefGoogle ScholarPubMed
92Larroche, JC, Droulle, P, Delezoide, AL, Narcy, F, Nessman, C. Brain damage in monozygous twins. Biol Neonat 1990; 57: 261–78.CrossRefGoogle ScholarPubMed
93Fusi, L, Gordon, H. Twin pregnancy complicated by single intrauterine death. Problems and outcome with conservative management. Br J Obstet Gynecol 1990; 97: 511–16.CrossRefGoogle ScholarPubMed
94Fusi, L, McPartland, P, Fisk, N, Nicolini, U, Wigglesworth, J. Acute twin-twin transfusion: possible mechanisms for brain damaged survivors after intrauterine death of a monochorionic twin. Obstet Gynecol 1991; 78: 517–20.Google ScholarPubMed
95Nikkels, PG, Hack, KE, van Gemert, MJ. Pathology of twin placentas with special attention to monochorionic twin placentas. J Clin Pathol 2008; 61: 1247–253.CrossRefGoogle ScholarPubMed
96Pharoah, PO, Adi, Y. Consequences of in-utero death in a twin pregnancy. Lancet 2000; 355: 1597–602.CrossRefGoogle Scholar
97Gonen, R. The origin of brain lesions in survivors of twin gestations complicated by fetal death. Am J Obstet Gynecol 1991; 165: 1897–898.CrossRefGoogle ScholarPubMed
98Nicolini, U, Pisoni, MP, Cela, E, Roberts, A. Fetal blood sampling immediately before and within 24 hours of death in monochorionic twin pregnancies complicated by intrauterine death. Am J Obstet Gynecol 1998; 179: 800803.CrossRefGoogle ScholarPubMed
99Senat, MV, Loizeau, S, Couderc, S, Bernard, JP, Ville, Y. The value of middle cerebral peak systolic velocity in the diagnosis of fetal anemia after intrauterine detah of one monochorionic twin. Am J Obstet Gynecol 2003; 189: 1320–324.CrossRefGoogle Scholar
100Quarello, E, Stirnemann, J, Nassar, M, Nasr, B, Bernard, JP, Leleu-Huard, F, et al. Outcome of anaemic monochorionic single survivors following early intrauterine rescue transfusion in cases of feto-fetal transfusion syndrome. BJOG 2008; 115: 595601.CrossRefGoogle ScholarPubMed
101Barigye, O, Pasquini, L, Galea, P, Chambers, H, Chappell, L, Fisk, NM. High risk of unexpected late fetal death in monochorionic twins despite intensive ultrasound surveillance: a cohort study. PLoS Med 2005; 2: e172.CrossRefGoogle ScholarPubMed
102Gratacós, E, Carreras, E, Becker, J, Lewi, L, Enríquez, G, Perapoch, J et al. Prevalence of neurological damage in monochorionic twins with selective intrauterine growth restriction and intermittent absent or reversed end-diastolic umbilical artery flow. Ultrasound Obstet Gynecol 2004; 24: 159–63.CrossRefGoogle ScholarPubMed
103Weig, SG, Marshall, PC, Abroms, IF, Gauthier, NS. Patterns of cerebral injury and clinical presentation in the vascular disruptive syndrome of monozygotic twins. Pediatr Neurol 1995; 13: 279–85.CrossRefGoogle ScholarPubMed
104Patten, RM, Mack, LA, Nyberg, DA, Filly, RA. Twin embolization syndrome: prenatal sonographic detection and significance. Radiol 1989; 173: 685–89.CrossRefGoogle ScholarPubMed
105Langer, B, Boudier, E, Gasser, B, Christmann, D, Messer, J, Schlaeder, G. Antenatal diagnosis of brain damage in the survivor after the second trimester death of a monochorionic monoamniotic co-twin: case report and literature review. Fetal Diagn Ther 1997; 12: 286–91.CrossRefGoogle ScholarPubMed
106Righini, A, Kustermann, A, Parazzini, C, Fogliani, R, Ceriani, F, Triulzi, F. Diffusion-weighted magnetic resonance imaging of acute hypoxic-ischemic cerebral lesions in the survivor of a monochorionic twin pregnancy: case report. Ultrasound Obstet Gynecol 2007; 29: 453–56.CrossRefGoogle ScholarPubMed
107Jelin, AC, Norton, ME, Bartha, AI, Fick, AL, Glenn, OA. Intracranial magnetic resonance imaging findings in the surviving fetus after spontaneous monochorionic cotwin demise. Am J Obstet Gynecol 2008; 199: 398 e1–5.CrossRefGoogle ScholarPubMed
108Quarello, E, Molho, M, Ville, Y. Incidence, mechanisms, and patterns of fetal cerebral lesions in twin-to-twin transfusion syndrome. J Matern Fetal Neonatal Med 2007; 20: 589–97.CrossRefGoogle ScholarPubMed
109Simonazzi, G, Segata, M, Ghi, T, Sandri, F, Ancora, G, Bernardi, B et al. Accurate neurosonographic prediction of brain injury in the surviving fetus after the death of a monochorionic cotwin. Ultrasound Obstet Gynecol 2006; 27: 517–21.CrossRefGoogle ScholarPubMed
110Carson, JCL. Twins born with an interval of forty-four days. Br Med J 1880; i: 242.Google Scholar
111Abrams, RH. Double pregnancy: Report of a case with thirty-five days between deliveries. Obstet Gynecol 1957; 9: 435–37.Google ScholarPubMed
112Drucker, P, Finkel, J, Savel, LE. Sixty-five day interval between the birth of twins. Am J Obstet Gynecol 1960; 80: 761–62.CrossRefGoogle ScholarPubMed
113Thomsen, RJ. Delayed interval delivery of a twin pregnancy. Obstet Gynecol 1978; 52: s37–40.Google ScholarPubMed
114Poeschmann, PP, van Oppen, CA, Bruinse, HW. Delayed interval delivery in multiple pregnancies: report of three cases and review of the literature. Obstet Gynecol Surv 1992; 47: 139–47.CrossRefGoogle ScholarPubMed
115Wittmann, BK, Farquharson, D, Wong, GP, Baldwin, V, Wadsworth, LD, Elit, L. Delayed delivery of second twin: report of four cases and review of the literature. Obstet Gynecol 1992; 79: 260–63.Google ScholarPubMed
116Cristinelli, S, Fresson, J, Andre, M, Monnier-Barbarino, P. Management of delayed-interval delivery in multiple gestations. Fetal Diagn Ther 2005; 20: 285–90.CrossRefGoogle ScholarPubMed
117Fayad, S, Bongain, A, Holhfeld, P, Janky, E, Durand-Reville, M, Ejnes, L et al. Delayed delivery of second twin: a multicentre study of 35 cases. Eur J Obstet Gynecol Reprod Biol 2003; 109: 1620.CrossRefGoogle ScholarPubMed
118Zhang, J, Hamilton, B, Martin, J, Trumble, A. Delayed interval delivery and infant survival: a population-based study. Am J Obstet Gynecol 2004; 191: 470–76.CrossRefGoogle ScholarPubMed
119Oyelese, Y, Ananth, CV, Smulian, JC, Vintzileos, AM. Delayed interval delivery in twin pregnancies in the United States: Impact on perinatal mortality and morbidity. Am J Obstet Gynecol 2005; 192: 439–44.CrossRefGoogle ScholarPubMed
120Farkouh, LJ, Sabin, ED, Heyborne, KD, Lindsay, LG, Porreco, RP. Delayed-interval delivery: extended series from a single maternal-fetal medicine practice. Am J Obstet Gynecol 2000; 183: 1499–503.CrossRefGoogle ScholarPubMed
121Long, MG, Gibb, DM, Kempley, S, Cardozo, LD, Nicolaides, K, Gamsu, H. Retention of the second twin: a viable option? Case reports. Br J Obstet Gynaecol 1991; 98: 1295–299.CrossRefGoogle ScholarPubMed
122Bagga, R, Keepanasseril, A, Suri, V. Is gestation greater than 28 weeks a contraindication to attempting delayed-delivery in twin pregnancies? J Obstet Gynaecol 2007; 27: 734–35.CrossRefGoogle Scholar
123Flynn, A, Scott, F, Birrell, W, Evans, N. Delayed-interval delivery in a quadruplet pregnancy: the use of transperineal ultrasound and cervical cerclage. Aust N Z J Obstet Gynaecol 1995; 35: 280–82.CrossRefGoogle Scholar
124Kalchbrenner, MA, Weisenborn, EJ, Chyu, JK, Kaufman, HK, Losure, TA. Delayed delivery of multiple gestations: maternal and neonatal outcomes. Am J Obstet Gynecol 1998; 179: 1145–149.CrossRefGoogle ScholarPubMed
125van Doorn, HC, van Wezel-Meijler, G, van Geijn, HP, Dekker, GA. Delayed interval delivery in multiple pregnancies. Is optimism justified? Acta Obstet Gynecol Scand 1999; 78: 710–15.CrossRefGoogle ScholarPubMed
126Goldenberg, RL, Iams, JD, Miodovnik, M, Van Dorsten, JP, Thurnau, G, Bottoms, S et al. The preterm prediction study: risk factors in twin gestations. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol 1996; 175: 1047–53.CrossRefGoogle ScholarPubMed
127Brambati, B, Tului, L, Camurri, L, Guercilena, S. First-trimester fetal reduction to a singleton infant or twins: outcome in relation to the final number and karyotyping before reduction by transabdominal chorionic villus sampling. Am J Obstet Gynecol 2004; 191: 20352040.CrossRefGoogle ScholarPubMed
128Lembet, A, Selam, B, Gaddipati, S, Berkowitz, RL, Salafia, CM. Shortened gestational age following multifetal pregnancy reduction: can chronic placental inflammation be the explanation? J Matern Fetal Med 2001; 10: 149–54.CrossRefGoogle ScholarPubMed
129Wennerholm, UB, Holm, B, Mattsby-Baltzer, I, Nielsen, T, Platz-Christensen, J, Sundell, G et al. Fetal fibronectin, endotoxin, bacterial vaginosis and cervical length as predictors of preterm birth and neonatal morbidity in twin pregnancies. Br J Obstet Gynaecol 1997; 104: 1398–404.CrossRefGoogle ScholarPubMed
130Skentou, C, Souka, AP, To, MS, Liao, AW, Nicolaides, KH. Prediction of preterm delivery in twins by cervical assessment at 23 weeks. Ultrasound Obstet Gynecol 2001; 17: 710.CrossRefGoogle ScholarPubMed
131Guzman, ER, Walters, C, O'Reilly-Green, C, Kinzler, WL, Waldron, R, Nigam, J, et al. Use of cervical ultrasonography in prediction of spontaneous preterm birth in twin gestations. Am J Obstet Gynecol 2000; 183: 1103–107.CrossRefGoogle ScholarPubMed
132Vayssiere, C, Favre, R, Audibert, F, Chauvet, MP, Gaucherand, P, Tardif, D et al. Cervical length and funneling at 22 and 27 weeks to predict spontaneous birth before 32 weeks in twin pregnancies: a French prospective multicenter study. Am J Obstet Gynecol 2002; 187: 1596–604.CrossRefGoogle ScholarPubMed
133Imseis, HM, Albert, TA, Iams, JD. Identifying twin gestations at low risk for preterm birth with a transvaginal ultrasonographic cervical measurement at 24 to 26 weeks’ gestation. Am J Obstet Gynecol 1997; 177: 1149–155.CrossRefGoogle ScholarPubMed
134Rebarber, A, Carreno, CA, Lipkind, H, Funai, EF, Maturi, J, Kuczynski, E, et al. Cervical length after multifetal pregnancy reduction in remaining twin gestations. Am J Obstet Gynecol 2001; 185: 1113–117.CrossRefGoogle ScholarPubMed