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INSULIN-LIKE GROWTH FACTORS AND PLACENTAL FUNCTION

Part of: Bespoke shallow archive Weizmann

Published online by Cambridge University Press:  01 August 2007

NATALIA SCHLABRITZ-LOUTSEVITCH ,
CUN LI  and
PETER W NATHANIELSZ
NATALIA SCHLABRITZ-LOUTSEVITCH*
Affiliation:
University of Texas Health Science Center Medical School, Department of Obstetrics and Gynecology, San Antonio, Texas and Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas.
CUN LI
Affiliation:
University of Texas Health Science Center Medical School, Department of Obstetrics and Gynecology, San Antonio, Texas and Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas.
PETER W NATHANIELSZ
Affiliation:
University of Texas Health Science Center Medical School, Department of Obstetrics and Gynecology, San Antonio, Texas and Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas.
*
Address for correspondence: Natalia Schlabritz-Loutsevitch, Southwest National Primate Research Center, PO Box 760549 San Antonio, Texas 78245-5049, United States of America.
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Extract

Placentas from different species differ not only in their cellular structure and normal trajectory of growth but also in the architecture of their placental vasculature and the transport and exchange mechanisms that determine nutritional transfer from mother to fetus and waste disposal from fetus to mother.1 Many maternal and fetal hormonal and nutritional factors, as well as placental paracrine and autocrine systems affect placental growth and development throughout gestation.2 Nutrients delivered from the maternal circulation are as important for placental growth as they are for fetal growth. In addition to passing across the placenta to provide the building blocks for fetal growth, amino acids, carbohydrate and lipids are incorporated into the placenta.

Type
Research Article
Information
Fetal and Maternal Medicine Review , Volume 18 , Issue 3 , August 2007 , pp. 201 - 224
Copyright
Copyright © Cambridge University Press 2007

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