Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-20T03:23:01.092Z Has data issue: false hasContentIssue false

HEPATITIS B AND PREGNANCY, THE SCIENTIFIC BASIS FOR PERINATAL PREVENTION

Published online by Cambridge University Press:  15 March 2010

CHIEN-YI CHEN
Affiliation:
Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
MEI-HWEI CHANG*
Affiliation:
Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
*
Mei-Hwei Chang, Department of Pediatrics, National Taiwan University Hospital, No 7 Chung-Shan South Road, Taipei 100, Taiwan Email address: [email protected]

Extract

Hepatitis B and its complications are one of the major global health problems. Around 2 billion individuals are infected by hepatitis B virus (HBV) worldwide, more than 350 million are chronically infected, and approximately 15 to 40 percents of them will develop serious complications such as liver cirrhosis, hepatic failure, or hepatocellular carcinoma (HCC). The worldwide prevalence of chronic HBV infection ranges from 0.1 to 20 percent and varies widely in different geographic areas. According to the prevalence rate, WHO has classified countries into 3 levels: high areas (>8%) such as Africa, Asia, Western Pacific and Middle East; intermediate areas (2–8%) such as South America and Eastern Europe, and low areas (<2%) such as Western Europe, North America, and Australia.

Type
Research Article
Copyright
Copyright © Cambridge University Press 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1Lee, WM. Hepatitis B virus infection. N Engl J Med 1997; 337: 1733–45.CrossRefGoogle ScholarPubMed
2Lok, AS. Chronic hepatitis B. N Engl J Med 2002; 346: 1682–683.CrossRefGoogle ScholarPubMed
3Lavanchy, D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004; 11: 97107.CrossRefGoogle ScholarPubMed
4Van Herck, K, Van Damme, P. Benefits of early hepatitis B immunization programs for newborns and infants. Pediatr Infect Dis J 2008; 27: 861–69.CrossRefGoogle ScholarPubMed
5Chen, CJ, Wang, LY, Yu, MW. Epidemiology of hepatitis B virus infection in the Asia-Pacific region. J Gastroenterol Hepatol 2000; 15 Suppl: E36.Google ScholarPubMed
6Dinsmoor, MJ. Hepatitis in the obstetric patient. Infect Dis Clin North Am 1997; 11: 7791.CrossRefGoogle ScholarPubMed
7Ganem, D, Prince, AM. Hepatitis B virus infection–natural history and clinical consequences. N Engl J Med 2004; 350: 1118–129.CrossRefGoogle ScholarPubMed
8Wright, TL, Mamish, D, Combs, C, Kim, M, Donegan, E, Ferrell, L et al. Hepatitis B virus and apparent fulminant non-A, non-B hepatitis. Lancet 1992; 339: 952–55.CrossRefGoogle ScholarPubMed
9Gambarin-Gelwan, M. Hepatitis B in pregnancy. Clin Liver Dis 2007; 11: 945–63, x.CrossRefGoogle ScholarPubMed
10Hieber, JP, Dalton, D, Shorey, J, Combes, B. Hepatitis and pregnancy. J Pediatr 1977; 91: 545–49.CrossRefGoogle Scholar
11Levy, M, Koren, G. Hepatitis B vaccine in pregnancy: maternal and fetal safety. Am J Perinatol 1991; 8: 227–32.CrossRefGoogle ScholarPubMed
12Chu, CM, Liaw, YF. Natural history of chronic hepatitis B virus infection: an immunopathological study. J Gastroenterol Hepatol 1997; 12: S21822.CrossRefGoogle ScholarPubMed
13Lok, AS, McMahon, BJ. Chronic hepatitis B. Hepatology 2007; 45: 507–39.CrossRefGoogle ScholarPubMed
14Chang, MH. Natural history of hepatitis B virus infection in children. J Gastroenterol Hepatol 2000; 15 Suppl: E169.CrossRefGoogle ScholarPubMed
15Chang, MH. Hepatitis B virus infection. Semin Fetal Neonatal Med 2007; 12: 160–67.CrossRefGoogle ScholarPubMed
16Hsu, HY, Chang, MH, Lee, CY, Chen, JS, Hsu, HC, Chen, DS. Spontaneous loss of HBsAg in children with chronic hepatitis B virus infection. Hepatology 1992; 15: 382–86.CrossRefGoogle ScholarPubMed
17Hadziyannis, SJ, Vassilopoulos, D. Hepatitis B e antigen-negative chronic hepatitis B. Hepatology 2001; 34: 617–24.CrossRefGoogle ScholarPubMed
18Kwan, LC, Ho, YY, Lee, SS. The declining HBsAg carriage rate in pregnant women in Hong Kong. Epidemiol Infect 1997; 119: 281–83.CrossRefGoogle ScholarPubMed
19Chatterjee, S, Ravishankar, K, Chatterjee, R, Narang, A, Kinikar, A. Hepatitis B prevalence during pregnancy. Indian Pediatr 2009; 46: 10051008. Epub 2009 Apr 1.Google ScholarPubMed
20Denis, F, Ranger-Rogez, S, Alain, S, Mounier, M, Debrock, C, Wagner, A et al. Screening of pregnant women for hepatitis B markers in a French Provincial University Hospital (Limoges) during 15 years. Eur J Epidemiol 2004; 19: 973–78.CrossRefGoogle Scholar
21Knorr, B, Maul, H, Schnitzler, P. Prevalence of hepatitis B virus infection among women at reproductive age at a German university hospital. J Clin Virol 2008; 42: 422–24.CrossRefGoogle ScholarPubMed
22Nguyen, G, Garcia, RT, Nguyen, N, Trinh, H, Keeffe, EB, Nguyen, MH. Clinical course of hepatitis B virus infection during pregnancy. Aliment Pharmacol Ther 2009; 29: 755–64.CrossRefGoogle ScholarPubMed
23Angel Garcia, AL. Effect of pregnancy on pre-existing liver disease physiological changes during pregnancy. Ann Hepatol 2006; 5: 184–86.CrossRefGoogle ScholarPubMed
24Soderstrom, A, Norkrans, G, Lindh, M. Hepatitis B virus DNA during pregnancy and post partum: aspects on vertical transmission. Scand J Infect Dis 2003; 35: 814–19.CrossRefGoogle ScholarPubMed
25ter Borg, MJ, Leemans, WF, de Man, RA, Janssen, HL. Exacerbation of chronic hepatitis B infection after delivery. J Viral Hepat 2008; 15: 3741.CrossRefGoogle ScholarPubMed
26Lin, HH, Chen, PJ, Chen, DS, Sung, JL, Yang, KH, Young, YC et al. Postpartum subsidence of hepatitis B viral replication in HBeAg-positive carrier mothers. J Med Virol 1989; 29: 16.CrossRefGoogle ScholarPubMed
27Lin, HH, Wu, WY, Kao, JH, Chen, DS. Hepatitis B post-partum e antigen clearance in hepatitis B carrier mothers: Correlation with viral characteristics. J Gastroenterol Hepatol 2006; 21: 605609.CrossRefGoogle ScholarPubMed
28Tan, HH, Lui, HF, Chow, WC. Chronic hepatitis B virus (HBV) infection in pregnancy. Hepatol Int 2008; 2: 370–75.CrossRefGoogle ScholarPubMed
29Su, WH, Wang, PH, Yuan, CC, Chang, SP. Fetal meconium peritonitis in the infant of a woman with fulminant hepatitis B. A case report. J Reprod Med 2002; 47: 952–54.Google ScholarPubMed
30Lao, TT, Tse, KY, Chan, LY, Tam, KF, Ho, LF. HBsAg carrier status and the association between gestational diabetes with increased serum ferritin concentration in Chinese women. Diabetes Care 2003; 26: 3011–16.CrossRefGoogle ScholarPubMed
31Tse, KY, Ho, LF, Lao, T. The impact of maternal HBsAg carrier status on pregnancy outcomes: a case-control study. J Hepatol 2005; 43: 771–75.CrossRefGoogle ScholarPubMed
32Pastorek, JG 2nd, Miller, JM Jr., Summers PR. The effect of hepatitis B antigenemia on pregnancy outcome. Am J Obstet Gynecol 1988; 158: 486–89.CrossRefGoogle ScholarPubMed
33Wong, S, Chan, LY, Yu, V, Ho, L. Hepatitis B carrier and perinatal outcome in singleton pregnancy. Am J Perinatol 1999; 16: 485–88.CrossRefGoogle ScholarPubMed
34European Association For The Study Of The Liver EASL Clinical Practice Guidelines: management of chronic hepatitis B. J Hepatol 2009; 50: 227–42.CrossRefGoogle Scholar
35Liaw, YF, Leung, N, Kao, JH, Piratvisuth, T, Gane, E, Han, KH et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update. Hepatol Int 2008; 2: 263–83.CrossRefGoogle ScholarPubMed
36Tran, TT. Management of hepatitis B in pregnancy: weighing the options. Cleve Clin J Med 2009; 76 Suppl 3: S2529.Google ScholarPubMed
37Ikeda, T, Ch'ng, TW, Oleske, JM. Recommendations in pediatric antiretroviral therapy. Expert Opin Pharmacother 2007; 8: 155–66.CrossRefGoogle ScholarPubMed
38Mirochnick, M, Capparelli, E. Pharmacokinetics of antiretrovirals in pregnant women. Clin Pharmacokinet 2004; 43: 1071–87.CrossRefGoogle ScholarPubMed
39Watts, DH, Covington, DL, Beckerman, K, Garcia, P, Scheuerle, A, Dominguez, K et al. Assessing the risk of birth defects associated with antiretroviral exposure during pregnancy. Am J Obstet Gynecol 2004; 191: 985–92.CrossRefGoogle ScholarPubMed
40Su, GG, Pan, KH, Zhao, NF, Fang, SH, Yang, DH, Zhou, Y. Efficacy and safety of lamivudine treatment for chronic hepatitis B in pregnancy. World J Gastroenterol 2004; 10: 910–12.CrossRefGoogle ScholarPubMed
41Chen, DS, Hsu, NH, Sung, JL, Hsu, TC, Hsu, ST, Kuo, YT et al. A mass vaccination program in Taiwan against hepatitis B virus infection in infants of hepatitis B surface antigen-carrier mothers. JAMA 1987; 257: 2597–603.CrossRefGoogle ScholarPubMed
42Cobey, FC, Salem, RR. A review of liver masses in pregnancy and a proposed algorithm for their diagnosis and management. Am J Surg 2004; 187: 181–91.CrossRefGoogle Scholar
43Lau, WY, Leung, WT, Ho, S, Lam, SK, Li, CY, Johnson, PJ et al. Hepatocellular carcinoma during pregnancy and its comparison with other pregnancy-associated malignancies. Cancer 1995; 75: 2669–676.3.0.CO;2-B>CrossRefGoogle ScholarPubMed
44Yang, HI, Lu, SN, Liaw, YF, You, SL, Sun, CA, Wang, LY et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med 2002; 347: 168–74.CrossRefGoogle ScholarPubMed
45Fwu, CW, Chien, YC, Kirk, GD, Nelson, KE, You, SL, Kuo, HS et al. Hepatitis B virus infection and hepatocellular carcinoma among parous Taiwanese women: nationwide cohort study. J Natl Cancer Inst 2009; 101: 10191027.CrossRefGoogle ScholarPubMed
46Chen, CJ, Yu, MW, Liaw, YF. Epidemiological characteristics and risk factors of hepatocellular carcinoma. J Gastroenterol Hepatol 1997; 12: S294308.CrossRefGoogle ScholarPubMed
47Almog, Y, Klein, A, Adler, R, Laub, O, Tur-Kaspa, R. Oestrogen suppresses hepatitis B virus expression in male athymic mice transplanted with HBV transfected Hep G-2 cells. Antiviral Res 1992; 19: 285–93.CrossRefGoogle ScholarPubMed
48Naugler, WE, Sakurai, T, Kim, S, Maeda, S, Kim, K, Elsharkawy, AM et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007; 317: 121–24.CrossRefGoogle ScholarPubMed
49Yu, MW, Chang, HC, Chang, SC, Liaw, YF, Lin, SM, Liu, CJ et al. Role of reproductive factors in hepatocellular carcinoma: Impact on hepatitis B- and C-related risk. Hepatology 2003; 38: 1393–400.Google ScholarPubMed
50Gisi, P, Floyd, R. Hepatocellular carcinoma in pregnancy. A case report. J Reprod Med 1999; 44: 6567.Google ScholarPubMed
51Stevens, CE, Beasley, RP, Tsui, J, Lee, WC. Vertical transmission of hepatitis B antigen in Taiwan. N Engl J Med 1975; 292: 771–74.CrossRefGoogle ScholarPubMed
52Alter, MJ. Epidemiology of hepatitis B in Europe and worldwide. J Hepatol 2003; 39 Suppl 1: S6469.CrossRefGoogle ScholarPubMed
53Chang, MH. Chronic hepatitis virus infection in children. J Gastroenterol Hepatol 1998; 13: 541–48.CrossRefGoogle ScholarPubMed
54Beasley, RP, Hwang, LY, Lin, CC, Leu, ML, Stevens, CE, Szmuness, et al. Incidence of hepatitis B virus infections in preschool children in Taiwan. J Infect Dis 1982; 146: 198204.CrossRefGoogle ScholarPubMed
55McMahon, BJ, Alward, WL, Hall, DB, Heyward, WL, Bender, TR, Francis, DP et al. Acute hepatitis B virus infection: relation of age to the clinical expression of disease and subsequent development of the carrier state. J Infect Dis 1985; 151: 599603.CrossRefGoogle Scholar
56Beasley, RP, Hwang, LY, Lin, CC, Ko, YC, Twu, SJ. Incidence of hepatitis among students at a university in Taiwan. Am J Epidemiol 1983; 117: 213–22.CrossRefGoogle Scholar
57Okada, K, Kamiyama, I, Inomata, M, Imai, M, Miyakawa, Y. e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. N Engl J Med 1976; 294: 746–49.CrossRefGoogle ScholarPubMed
58Xu, DZ, Yan, YP, Choi, BC, Xu, JQ, Men, K, Zhang, JX et al. Risk factors and mechanism of transplacental transmission of hepatitis B virus: a case-control study. J Med Virol 2002; 67: 2026.CrossRefGoogle ScholarPubMed
59Milich, D, Liang, TJ. Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection. Hepatology 2003; 38: 10751086.CrossRefGoogle ScholarPubMed
60Arakawa, K, Tsuda, F, Takahashi, K, Ise, I, Naito, S, Kosugi, E et al. Maternofetal transmission of IgG-bound hepatitis B e antigen. Ped Res 1982; 16: 247–50.CrossRefGoogle ScholarPubMed
61Hsu, HY, Chang, MH, Hsieh, KH, Lee, CY, Lin, HH, Hwang, LH et al. Cellular immune response to HBcAg in mother-to-infant transmission of hepatitis B virus. Hepatology 1992; 15: 770–76.CrossRefGoogle ScholarPubMed
62Bortolotti, F, Cadrobbi, P, Crivellaro, C et al. Long-term outcome of chronic type B hepatitis in patients who acquire hepatitis B virus infection in childhood. Gastroenterol 1990; 99: 805–10.CrossRefGoogle ScholarPubMed
63Lok, AS, Lai, CL. A longitudinal follow-up of asymptomatic hepatitis B surface antigen-positive Chinese children. Hepatology 1988; 8: 1130–133.CrossRefGoogle ScholarPubMed
64Boxall, EH, Sira, J, Standish, RA, Davies, P, Sleight, E, Dhillon, AP et al. Natural history of hepatitis B in perinatally infected carriers. Arch Dis Child Fetal Neonatal Ed 2004; 89: F45660.CrossRefGoogle ScholarPubMed
65Burk, RD, Hwang, LY, Ho, GY, Shafritz, DA, Beasley, RP. Outcome of perinatal hepatitis B virus exposure is dependent on maternal virus load. J Infect Dis 1994; 170: 1418–423.CrossRefGoogle ScholarPubMed
66Wang, Z, Zhang, J, Yang, H, Li, X, Wen, S, Guo, Y et al. Quantitative analysis of HBV DNA level and HBeAg titer in hepatitis B surface antigen positive mothers and their babies: HBeAg passage through the placenta and the rate of decay in babies. J Med Virol 2003; 71: 360–66.CrossRefGoogle Scholar
67Li, XM, Shi, MF, Yang, YB, Shi, ZJ, Hou, HY, Shen, HM et al. Effect of hepatitis B immunoglobulin on interruption of HBV intrauterine infection. World J Gastroenterol 2004; 10: 3215–217.CrossRefGoogle ScholarPubMed
68Lin, HH, Lee, TY, Chen, DS, Sung, JL, Ohto, H, Etoh, T et al. Transplacental leakage of HBeAg-positive maternal blood as the most likely route in causing intrauterine infection with hepatitis B virus. J Pediatr 1987; 111: 877–81.CrossRefGoogle ScholarPubMed
69Gu, SQ, Zhu, QR, Yu, H, Fei, LE, Dong, ZQ, Pu, DP. Relationship between genetic polymorphism of tumor necrosis factor-alpha and susceptibility to intrauterine HBV infection. Zhonghua Gan Zang Bing Za Zhi 2004; 12: 538–39.Google ScholarPubMed
70Zhu, QR, Ge, YL, Gu Yu, H, Yu, H, Wang, JS, Gu, XH et al. Relationship between cytokines gene polymorphism and susceptibility to hepatitis B virus intrauterine infection. Chin Med J (Engl) 2005; 118: 1604–609.Google ScholarPubMed
71Yu, H, Zhu, QR, Gu, SQ, Fei, LE. Relationship between IFN-gamma gene polymorphism and susceptibility to intrauterine HBV infection. World J Gastroenterol 2006; 12: 2928–931.CrossRefGoogle ScholarPubMed
72Liu, HY, Kong, BH, Luo, X, Xu, YP, Dai, MS, Jiang, S. Study on the association between maternal-infantile vertical transmission of hepatitis B virus and human leukocyte antigen DR gene domain. Zhonghua Fu Chan Ke Za Zhi 2003; 38: 599603.Google Scholar
73Carman, WF, Zanetti, AR, Karayiannis, P et al. Vaccine-induced escape mutant of hepatitis B virus. Lancet 1990; 336: 325–29.CrossRefGoogle ScholarPubMed
74Su, HX, Xu, DZ, Li, D, Zhang, JX, Lu, J, Choi, BC et al. Heterogeneity analysis of the hepatitis B virus genome in intrauterine infection. J Med Virol 2005; 77: 180–87.CrossRefGoogle ScholarPubMed
75Cheng, H, Su, H, Wang, S, Shao, Z, Men, K, Li, M et al. Association between genomic heterogeneity of hepatitis B virus and intrauterine infection. Virology 2009; 387: 168–75.CrossRefGoogle ScholarPubMed
76Cacciola, I, Cerenzia, G, Pollicino, T, Squadrito, G, Castellaneta, S, Zanetti, AR et al. Genomic heterogeneity of hepatitis B virus (HBV) and outcome of perinatal HBV infection. J Hepatol 2002; 36: 426–32.CrossRefGoogle ScholarPubMed
77Bai, H, Zhang, L, Ma, L, Dou, XG, Feng, GH, Zhao, GZ. Relationship of hepatitis B virus infection of placental barrier and hepatitis B virus intra-uterine transmission mechanism. World J Gastroenterol 2007; 13: 3625–630.CrossRefGoogle ScholarPubMed
78Lee, AK, Ip, HM, Wong, VC. Mechanisms of maternal-fetal transmission of hepatitis B virus. J Infect Dis 1978; 138: 668–71.CrossRefGoogle ScholarPubMed
79Alexander, JM, Ramus, R, Jackson, G, Sercely, B, Wendel, GD Jr.Risk of hepatitis B transmission after amniocentesis in chronic hepatitis B carriers. Infect Dis Obstet Gynecol 1999; 7: 283–86.CrossRefGoogle ScholarPubMed
80Towers, CV, Asrat, T, Rumney, P. The presence of hepatitis B surface antigen and deoxyribonucleic acid in amniotic fluid and cord blood. Am J Obstet Gynecol 2001; 184: 1514–518.CrossRefGoogle ScholarPubMed
81Chen, WH, Yin, CS, Chang, YK, Yan, JS, Chu, ML. Neonatal gastric aspirates as a predictor of perinatal hepatitis B virus infections. Int J Gynaecol Obstet 1998; 60: 1521.CrossRefGoogle ScholarPubMed
82Lin, HH, Kao, JH, Hsu, HY, Mizokami, M, Hirano, K, Chen, DS. Least microtransfusion from mother to fetus in elective cesarean delivery. Obstet Gynecol 1996; 87: 244–48.CrossRefGoogle ScholarPubMed
83Lee, SD, Lo, KJ, Tsai, YT, Wu, JC, Wu, TC, Yang, ZL et al. Role of caesarean section in prevention of mother-infant transmission of hepatitis B virus. Lancet 1988; 2: 833–34.CrossRefGoogle ScholarPubMed
84Wang, J, Zhu, Q, Zhang, X. Effect of delivery mode on maternal-infant transmission of hepatitis B virus by immunoprophylaxis. Chin Med J (Engl) 2002; 115: 1510–512.Google ScholarPubMed
85Yang, J, Zeng, XM, Men, YL, Zhao, LS. Elective caesarean section versus vaginal delivery for preventing mother to child transmission of hepatitis B virus–a systematic review. Virol J 2008; 5: 100.CrossRefGoogle ScholarPubMed
86Boxall, EH, Flewett, TH, Dane, DS, Cameron, CH, MacCallum, FO, Lee, TW. Hepatitis-B surface antigen in breast milk. Lancet 1974; 2: 10071008.CrossRefGoogle ScholarPubMed
87Lin, HH, Hsu, HY, Chang, MH, Chen, PJ, Chen, DS. Hepatitis B virus in the colostra of HBeAg-positive carrier mothers. J Pediatr Gastroenterol Nutr 1993; 17: 207–10.Google ScholarPubMed
88Mitsuda, T, Yokota, S, Mori, T, Ibe, M, Ookawa, N, Shimizu, H et al. Demonstration of mother-to-infant transmission of hepatitis B virus by means of polymerase chain reaction. Lancet 1989; 2: 886–88.CrossRefGoogle ScholarPubMed
89Beasley, RP, Stevens, CE, Shiao, IS, Meng, HC. Evidence against breast-feeding as a mechanism for vertical transmission of hepatitis B. Lancet 1975; 2: 740–41.CrossRefGoogle ScholarPubMed
90de Martino, M, Appendino, C, Resti, M, Rossi, ME, Muccioli, AT, Vierucci, A. Should hepatitis B surface antigen positive mothers breast feed? Arch Dis Child 1985; 60: 972–74.CrossRefGoogle ScholarPubMed
91Hill, JB, Sheffield, JS, Kim, MJ, Alexander, JM, Sercely, B, Wendel, GD. Risk of hepatitis B transmission in breast-fed infants of chronic hepatitis B carriers. Obstet Gynecol 2002; 99: 1049–52.Google ScholarPubMed
92Wang, JS, Zhu, QR, Wang, XH. Breastfeeding does not pose any additional risk of immunoprophylaxis failure on infants of HBV carrier mothers. Int J Clin Pract 2003; 57: 100102.CrossRefGoogle ScholarPubMed
93Gartner, LM, Morton, J, Lawrence, RA, Naylor, AJ, O'Hare, D, Schanler, RJ et al. Breastfeeding and the use of human milk. Pediatrics 2005; 115: 496506.Google ScholarPubMed
94Wang, JS, Chen, H, Zhu, QR. Transformation of hepatitis B serologic markers in babies born to hepatitis B surface antigen positive mothers. World J Gastroenterol 2005; 11: 3582–585.CrossRefGoogle ScholarPubMed
95Chang, MH, Lee, CY, Chen, DS, Hsu, HC, Lai, MY. Fulminant hepatitis in children in Taiwan: the important role of hepatitis B virus. J Pediatr 1987; 111: 3439.CrossRefGoogle ScholarPubMed
96Chen, HL, Chang, CJ, Kong, MS, Huang, FC, Lee, HC, Lin, CC et al. Pediatric fulminant hepatic failure in endemic areas of hepatitis B infection: 15 years after universal hepatitis B vaccination. Hepatology 2004; 39: 5863.CrossRefGoogle ScholarPubMed
97Chang, MH, Sung, JL, Lee, CY, Chen, CJ, Chen, JS, Hsu, HY et al. Factors affecting clearance of hepatitis B e antigen in hepatitis B surface antigen carrier children. J Pediatr 1989; 115: 385–90.CrossRefGoogle ScholarPubMed
98Chang, MH, Chen, DS, Hsu, HC, Hsu, HY, Lee, CY. Maternal transmission of hepatitis B virus in childhood hepatocellular carcinoma. Cancer 1989; 64: 2377–780.3.0.CO;2-8>CrossRefGoogle ScholarPubMed
99Hsu, HC, Wu, MZ, Chang, MH, Su, IJ, Chen, DS. Childhood hepatocellular carcinoma develops exclusively in hepatitis B surface antigen carriers in three decades in Taiwan. Report of 51 cases strongly associated with rapid development of liver cirrhosis. J Hepatol 1987; 5: 260–67.CrossRefGoogle ScholarPubMed
100Zuckerman, AJ. Prevention of primary liver cancer by immunization. N Engl J Med 1997; 336: 1906–907.CrossRefGoogle ScholarPubMed
101Lee, C, Gong, Y, Brok, J, Boxall, EH, Gluud, C. Effect of hepatitis B immunisation in newborn infants of mothers positive for hepatitis B surface antigen: systematic review and meta-analysis. Br Med J 2006; 332: 328–36.CrossRefGoogle ScholarPubMed
102Beasley, RP, Hwang, LY, Stevens, CE, Szmuness, W. Efficacy of hepatitis B immune globulin for prevention of perinatal transmission of the hepatitis B virus carrier state: final report of a randomized double-blind, placebo-controlled trial. Hepatology 1983; 3: 135–41.CrossRefGoogle ScholarPubMed
103Ni, YH, Huang, LM, Chang, MH et al. Two decades of universal hepatitis B vaccination in Taiwan: impact and implication for future strategies. Gastroenterology 2007; 132: 1287–293.CrossRefGoogle ScholarPubMed
104Assad, S, Francis, A. Over a decade of experience with a yeast recombinant hepatitis B vaccine. Vaccine 1999; 18: 5767.CrossRefGoogle Scholar
105But, DY, Lai, CL, Lim, WL, Fung, J, Wong, DK, Yuen, MF. Twenty-two years follow-up of a prospective randomized trial of hepatitis B vaccines without booster dose in children: final report. Vaccine 2008; 26: 6587–591.CrossRefGoogle ScholarPubMed
106Mast, EE, Margolis, HS, Fiore, AE, Brink, EW, Goldstein, ST, Wang, SA et al. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) part 1: immunization of infants, children, and adolescents. MMWR Recomm Rep 2005; 54: 131.Google ScholarPubMed
107Cowan, SA, Bagdonaite, J, Qureshi, K. Universal hepatitis B screening of pregnant women in Denmark ascertains substantial additional infections: results from the first five months. Euro Surveill 2006; 11: E060608 3.Google ScholarPubMed
108Malecki, JM, Guarin, O, Hulbert, A, Brumback, CL. Prevalence of hepatitis B surface antigen among women receiving prenatal care at the Palm Beach County Health Department. Am J Obstet Gynecol 1986; 154: 625–26.CrossRefGoogle ScholarPubMed
109Butterfield, CR, Shockley, M, San Miguel, G, Rosa, C. Routine screening for hepatitis B in an obstetric population. Obstet Gynecol 1990; 76: 2527.Google Scholar
110Fitzsimons, D, Francois, G, Hall, A, McMahon, B, Meheus, A, Zanetti, A et al. Long-term efficacy of hepatitis B vaccine, booster policy, and impact of hepatitis B virus mutants. Vaccine 2005; 23: 4158–166.CrossRefGoogle ScholarPubMed
111Chang, MH, Chen, CJ, Lai, MS, Hsu, HM, Wu, TC, Kong, MS et al. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group. N Engl J Med 1997; 336: 1855–859.CrossRefGoogle ScholarPubMed
112Chen, HL, Chang, MH, Ni, YH, Hsu, HY, Lee, PI, Lee, CY et al. Seroepidemiology of hepatitis B virus infection in children: Ten years of mass vaccination in Taiwan. JAMA 1996; 276: 906908.CrossRefGoogle ScholarPubMed
113Kao, JH, Hsu, HM, Shau, WY, Chang, MH, Chen, DS. Universal hepatitis B vaccination and the decreased mortality from fulminant hepatitis in infants in Taiwan. J Pediatr 2001; 139: 349–52.CrossRefGoogle ScholarPubMed
114Chang, MH, Shau, WY, Chen, CJ, Wu, TC, Kong, MS, Liang, DC et al. Hepatitis B vaccination and hepatocellular carcinoma rates in boys and girls. JAMA 2000; 284: 3040–42.CrossRefGoogle ScholarPubMed
115Lin, HH, Wang, LY, Hu, CT, Huang, SC, Huang, LC, Lin, SS et al. Decline of hepatitis B carrier rate in vaccinated and unvaccinated subjects: sixteen years after newborn vaccination program in Taiwan. J Med Virol 2003; 69: 471–74.CrossRefGoogle ScholarPubMed
116American Academy of Pediatrics. Hepatitis B. Report of the Committee on Infectious Diseases. 28th Ed Red Book Elk Grove, It. 2009; 337–356.Google Scholar
117Lau, YL, Tam, AY, Ng, KW, Tsoi, NS, Lam, B, Lam, P et al. Response of preterm infants to hepatitis B vaccine. J Pediatr 1992; 121: 962–65.CrossRefGoogle ScholarPubMed
118Linder, N, Handsher, R, German, B, Sirota, L, Bachman, M, Zinger, S et al. Controlled trial of immune response of preterm infants to recombinant hepatitis B and inactivated poliovirus vaccines administered simultaneously shortly after birth. Arch Dis Child Fetal Neonatal Ed 2000; 83: F2427.CrossRefGoogle ScholarPubMed
119Losonsky, GA, Wasserman, SS, Stephens, I, Mahoney, F, Armstrong, P, Gumpper, K et al. Hepatitis B vaccination of premature infants: a reassessment of current recommendations for delayed immunization. Pediatrics 1999; 103: E14.CrossRefGoogle ScholarPubMed
120Patel, DM, Butler, J, Feldman, S, Graves, GR, Rhodes, PG. Immunogenicity of hepatitis B vaccine in healthy very low birth weight infants. J Pediatr 1997; 131: 641–43.CrossRefGoogle ScholarPubMed
121Freitas da Motta, MS, Mussi-Pinhata, MM, Jorge, SM, Tachibana Yoshida, CF, Sandoval de Souza, CB. Immunogenicity of hepatitis B vaccine in preterm and full term infants vaccinated within the first week of life. Vaccine 2002; 20: 1557–62.CrossRefGoogle ScholarPubMed
122Huang, FY, Lee, PI, Lee, CY, Huang, LM, Chang, LY, Liu, SC. Hepatitis B vaccination in preterm infants. Arch Dis Child Fetal Neonatal Ed 1997; 77: F13538.CrossRefGoogle ScholarPubMed
123Kim, SC, Chung, EK, Hodinka, RL, DeMaio, J, West, DJ, Jawad, AF et al. Immunogenicity of hepatitis B vaccine in preterm infants. Pediatrics 1997; 99: 534–36.CrossRefGoogle ScholarPubMed
124Saari, TN. Immunization of preterm and low birth weight infants. American Academy of Pediatrics Committee on Infectious Diseases. Pediatrics 2003; 112: 193–98.CrossRefGoogle Scholar
125McMahon, BJ, Bruden, DL, Petersen, KM, Bulkow, LR, Parkinson, AJ, Nainan, O et al. Antibody levels and protection after hepatitis B vaccination: results of a 15-year follow-up. Ann Intern Med 2005; 142: 333–41.CrossRefGoogle ScholarPubMed
126McMahon, BJ, Dentinger, CM, Bruden, D, Zanis, C, Peters, H, Hurlburt, D et al. Antibody levels and protection after hepatitis B vaccine: results of a 22-year follow-up study and response to a booster dose. J Infect Dis 2009; 200: 1390–396.CrossRefGoogle ScholarPubMed
127Zanetti, AR, Mariano, A, Romano, L, D'Amelio, R, Chironna, M, Coppola, RC et al. Long-term immunogenicity of hepatitis B vaccination and policy for booster: an Italian multicentre study. Lancet 2005; 366: 1379–84.CrossRefGoogle ScholarPubMed
128Petersen, KM, Bulkow, LR, McMahon, BJ, Zanis, C, Getty, M, Peters, H et al. Duration of hepatitis B immunity in low risk children receiving hepatitis B vaccinations from birth. Pediatr Infect Dis J 2004; 23: 650–55.CrossRefGoogle ScholarPubMed
129Ni, YH, Chang, MH, Huang, LM, Chen, HL, Hsu, HY, Chiu, TY et al. Hepatitis B virus infection in children and adolescents in a hyperendemic area: 15 years after mass hepatitis B vaccination. Ann Intern Med 2001; 135: 796800.CrossRefGoogle Scholar
130Lu, JJ, Cheng, CC, Chou, SM, Hor, CB, Yang, YC, Wang, HL. Hepatitis B immunity in adolescents and necessity for boost vaccination: 23 years after nationwide hepatitis B virus vaccination program in Taiwan. Vaccine 2009; 27: 6613–618.CrossRefGoogle ScholarPubMed
131Wiseman, E, Fraser, MA, Holden, S, Glass, A, Kidson, BL, Heron, LG et al. Perinatal transmission of hepatitis B virus: an Australian experience. Med J Aust 2009; 190: 489–92.CrossRefGoogle ScholarPubMed
132Tang, JR, Hsu, HY, Lin, HH, Ni, YH, Chang, MH. Hepatitis B surface antigenemia at birth: a long-term follow-up study. J Pediatr 1998; 133: 374–77.CrossRefGoogle ScholarPubMed
133Ip, HM, Lelie, PN, Wong, VC, Kuhns, MC, Reesink, HW. Prevention of hepatitis B virus carrier state in infants according to maternal serum levels of HBV DNA. Lancet 1989; 1: 406–10.CrossRefGoogle ScholarPubMed
134del Canho, R, Grosheide, PM, Schalm, SW, de Vries, RR, Heijtink, RA. Failure of neonatal hepatitis B vaccination: the role of HBV-DNA levels in hepatitis B carrier mothers and HLA antigens in neonates. J Hepatol 1994; 20: 483–86.CrossRefGoogle ScholarPubMed
135del Canho, R, Grosheide, PM, Mazel, JA, Heijtink, RA, Hop, WC, Gerards, LJ et al. Ten-year neonatal hepatitis B vaccination program, The Netherlands, 1982–1992: protective efficacy and long-term immunogenicity. Vaccine 1997; 15: 1624–630.CrossRefGoogle ScholarPubMed
136Karthigesu, VD, Allison, LM, Ferguson, M, Howard, CR. A hepatitis B virus variant found in the sera of immunised children induces a conformational change in the HBsAg “a” determinant. J Med Virol 1999; 58: 346–52.3.0.CO;2-7>CrossRefGoogle Scholar
137Hsu, HY, Chang, MH, Ni, YH, Lin, HH, Wang, SM, Chen, DS. Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxis. Hepatology 1997; 26: 786–91.CrossRefGoogle ScholarPubMed
138Hsu, HY, Chang, MH, Liaw, SH, Ni, YH, Chen, HL. Changes of hepatitis B surface antigen variants in carrier children before and after universal vaccination in Taiwan. Hepatology 1999; 30: 1312–317.CrossRefGoogle ScholarPubMed
139Hsu, HY, Chang, MH, Ni, YH, Chen, HL. Survey of hepatitis B surface variant infection in children 15 years after a nationwide vaccination programme in Taiwan. Gut 2004; 53: 1499–503.CrossRefGoogle ScholarPubMed
140Chang, MH, Hsu, HY, Huang, LM, Lee, PI, Lin, HH, Lee, CY. The role of transplacental hepatitis B core antibody in the mother-to-infant transmission of hepatitis B virus. J Hepatol 1996; 24: 674–79.CrossRefGoogle ScholarPubMed
141Li, D, Xu, DZ, Choi, BC, Men, K, Zhang, JX, Lei, XY et al. Preliminary study on the efficacy and safety of lamivudine and interferon alpha therapy in decreasing serum HBV DNA level in HBV positive transgenic mice during pregnancy. J Med Virol 2005; 76: 203207.CrossRefGoogle Scholar
142van Zonneveld, M, van Nunen, AB, Niesters, HG, de Man, RA, Schalm, SW, Janssen, HL. Lamivudine treatment during pregnancy to prevent perinatal transmission of hepatitis B virus infection. J Viral Hepat 2003; 10: 294–97.CrossRefGoogle ScholarPubMed
143van Nunen, AB, de Man, RA, Heijtink, RA, Niesters, HG, Schalm, SW. Lamivudine in the last 4 weeks of pregnancy to prevent perinatal transmission in highly viremic chronic hepatitis B patients. J Hepatol 2000; 32: 1040–41.Google ScholarPubMed
144Xu, WM, Cui, YT, Wang, L, Yang, H, Liang, ZQ, Li, XM et al. Lamivudine in late pregnancy to prevent perinatal transmission of hepatitis B virus infection: a multicentre, randomized, double-blind, placebo-controlled study. J Viral Hepat 2009; 16: 94103.CrossRefGoogle ScholarPubMed
145Kazim, SN, Wakil, SM, Khan, LA, Hasnain, SE, Sarin, SK. Vertical transmission of hepatitis B virus despite maternal lamivudine therapy. Lancet 2002; 359: 1488–89.CrossRefGoogle ScholarPubMed
146Chotiyaputta, W, Lok, AS. Role of antiviral therapy in the prevention of perinatal transmission of hepatitis B virus infection. J Viral Hepat 2009; 16: 9193.CrossRefGoogle ScholarPubMed
147Xiao, XM, Li, AZ, Chen, X, Zhu, YK, Miao, J. Prevention of vertical hepatitis B transmission by hepatitis B immunoglobulin in the third trimester of pregnancy. Int J Gynaecol Obstet 2007; 96: 167–70.CrossRefGoogle ScholarPubMed
148Yuan, J, Lin, J, Xu, A, Li, H, Hu, B, Chen, J et al. Antepartum immunoprophylaxis of three doses of hepatitis B immunoglobulin is not effective: a single-centre randomized study. J Viral Hepat 2006; 13: 597604.CrossRefGoogle Scholar
149Xu, Q, Xiao, L, Lu, XB, Zhang, YX, Cai, X. A randomized controlled clinical trial: interruption of intrauterine transmission of hepatitis B virus infection with HBIG. World J Gastroenterol 2006; 12: 3434–437.CrossRefGoogle ScholarPubMed