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GENETICS OF CARDIAC MALFORMATIONS

Part of: Bespoke shallow archive Weizmann

Published online by Cambridge University Press:  01 May 2008

SHA TANG  and
TAOSHENG HUANG
SHA TANG
Affiliation:
Department of Pediatrics, Division of Human Genetics
TAOSHENG HUANG*
Affiliation:
Department of Pediatrics, Division of Human Genetics Department of Pathology & Laboratory Medicine Department of Developmental and Cell Biology, University of California, Irvine, CA, USA
*
Taosheng Huang, Division of Genetics, Department of Pediatrics, Developmental & Cell Biology and Pathology, 314 Robert R. Sprague Hall, University of California, Irvine, CA 92697.
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Abstract

Congenital heart disease is one of the most common major malformations in humans, contributing substantially to the financial and psychological burden of child healthcare. About one percent of children are born with heart defects, and every year, more children die from congenital heart disease than are diagnosed with cancer. A diagnosis of congenital heart disease is frightening for parents, particularly when it affects a fragile newborn. The heart is the first organ to be matured in a human fetus and if a particular congenital heart defect is compatible with fetal life, the child will be born with a defective heart. More than 300 genetic syndromes are associated with congenital cardiac defects. In this review, we will discuss the genetics of congenital heart disease, how to carry out a diagnosis of the genetic causes and how to provide counseling for families with congenital heart disease.

Type
Research Article
Information
Fetal and Maternal Medicine Review , Volume 19 , Issue 2 , May 2008 , pp. 105 - 118
Copyright
Copyright © Cambridge University Press 2008

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