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THE EVIDENCE FOR LATE-ONSET PRE-ECLAMPSIA AS A MATERNOGENIC DISEASE OF PREGNANCY

Published online by Cambridge University Press:  19 March 2013

ENRICO FERRAZZI ,
TAMARA STAMPALIJA  and
JEAN EDGARD AUPONT
ENRICO FERRAZZI*
Affiliation:
Department of Woman, Mother and Neonate, Buzzi Children's Hospital, University Department of Biological and Clinical Sciences, University of Milan, Milan, Italy.
TAMARA STAMPALIJA
Affiliation:
Department of Woman, Mother and Neonate, Buzzi Children's Hospital, University Department of Biological and Clinical Sciences, University of Milan, Milan, Italy.
JEAN EDGARD AUPONT
Affiliation:
High Risk Maternity, St. Damien Children Hospital, Port-au-Prince, Haiti.
*
Enrico Ferrazzi, Department of Woman, Mother and Neonate, Buzzi Children's Hospital, University Department of Biological and Clinical Sciences, University of Milan, Milan, Italy. Email: [email protected]
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Extract

It is our opinion that the evidence from epidemiological observations, clinical trials and biological studies is strong enough to support the view of different origin and phenotypes of pre-eclampsia: placental, which usually occurs (but not exclusively) early in pregnancy and is associated with poor early placentation of different severity with subsequent restriction of foetal growth, at different stages of gestation; and maternogenic, which generally occurs late in pregnancy and it is not related to placental insufficiency and foetal growth restriction.

Type
Review Article
Information
Fetal and Maternal Medicine Review , Volume 24 , Issue 1 , February 2013 , pp. 18 - 31
Copyright
Copyright © Cambridge University Press 2013

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References

REFERENCES

1, Duley L.The global impact of pre-eclampsia and eclampsia. Semin Perinatol 2009; 33 (3): 130–37. Epub 2009/05/26.CrossRefGoogle Scholar
2Khan, KS, Wojdyla, D, Say, L, Gulmezoglu, AM, Van Look, PF. WHO analysis of causes of maternal death: a systematic review. Lancet 2006; 367 (9516): 1066–74. Epub 2006/04/04.Google Scholar
3Zhang, C, Ning, Y. Effect of dietary and lifestyle factors on the risk of gestational diabetes: review of epidemiologic evidence. Am J Clin Nutrit 2011; 94 (6 Suppl): 1975S–9S. Epub 2011/05/27.CrossRefGoogle ScholarPubMed
4Bell, MJ. A historical overview of preeclampsia–eclampsia. J Obstet Gynecol Neonatal Nurs: JOGNN/NAACOG 2010; 39 (5):510–18. Epub 2010/10/06.Google Scholar
5Hutcheon, JA, Lisonkova, S, Joseph, KS. Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Best Pract Res Clin Obstet Gynaecol 2011; 25 (4): 391–403. Epub 2011/02/22.Google Scholar
6Steegers, AE, von Dadelszen, P, Duvekot, JJ, Pijnenborg, R. Seminar, Preeclampsia. Lancet 2010; 376: 631–44.Google Scholar
7Sibai, BM. Preeclampsia as a cause of preterm and late preterm (near-term) births. Semin Perinatol 2006; 30 (1): 16–19. Epub 2006/03/22.Google Scholar
8Magee, LA, Helewa, M, Moutquin, JM, von Dadelszen, P.Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. SOGC clinical Practice Guideline, No. 206, March 2008. JOGC 2008; 30 (Suppl 1): S1–S48.Google ScholarPubMed
9Burton, GJ, Woods, AW, Jauniaux, E, Kingdom, JC. Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta 2009; 30 (6): 473–82. Epub 2009/04/21.CrossRefGoogle ScholarPubMed
10Borzychowski, AM, Sargent, IL, Redman, CW. Inflammation and pre-eclampsia. Semin Fetal Neonatal Med. 2006; 11 (5): 309–16. Epub 2006/07/11.Google Scholar
11Long, PA, Abell, DA, Beischer, NA. Fetal growth retardation and pre-eclampsia. Br J Obstet Gynaecol 1980; 87 (1): 13–18. Epub 1980/01/01.Google Scholar
12Ferrazzi, E, Rigano, S, Padoan, A, Boito, S, Pennati, G, Galan, HL. Uterine artery blood flow volume in pregnant women with an abnormal pulsatility index of the uterine arteries delivering normal or intrauterine growth restricted newborns. Placenta 2011; 32 (7): 487–92. Epub 2011/05/03.Google Scholar
13Ferrazzi, E, Bulfamante, G, Mezzopane, R, Barbera, A, Ghidini, A, Pardi, G. Uterine Doppler velocimetry and placental hypoxic-ischemic lesion in pregnancies with fetal intrauterine growth restriction. Placenta 1999; 20 (5–6): 389–94. Epub 1999/07/27.CrossRefGoogle ScholarPubMed
14Alfirevic, Z, Stampalija, T, Gyte, GM. Fetal and umbilical Doppler ultrasound in high-risk pregnancies. Cochrane Database Syst Rev 2010; (1): CD007529. Epub 2010/01/22.Google Scholar
15Egbor, M, Ansari, T, Morris, N, Green, CJ, Sibbons, PD. Morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction. BJOG 2006; 113 (5): 580–89. Epub 2006/04/04.CrossRefGoogle ScholarPubMed
16Moldenhauer, JS, Stanek, J, Warshak, C, Khoury, J, Sibai, B. The frequency and severity of placental findings in women with preeclampsia are gestational age dependent. Am J Obstet Gynecol. 2003; 189 (4): 1173–77. Epub 2003/10/31.CrossRefGoogle ScholarPubMed
17Vadillo-Ortega, F, Perichart-Perera, O, Espino, S, Avila-Vergara, MA, Ibarra, I, Ahued, R, et al.Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high-risk population: randomised controlled trial. BMJ 2011; 342: d2901. Epub 2011/05/21.Google Scholar
18Martinelli, I, Ruggenenti, P, Cetin, I, Pardi, G, Perna, A, Vergani, P, et al.Heparin in pregnant women with previous placenta-mediated pregnancy complications: a prospective, randomized, multicenter, controlled clinical trial. Blood 2012; 119 (14): 3269–75. Epub 2012/02/01.Google Scholar
19Gris, JC, Chauleur, C, Molinari, N, Mares, P, Fabbro-Peray, P, Quere, I, et al.Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial. Thromb Haemost 2011; 106 (6): 1053–61. Epub 2011/09/29.Google Scholar
20Conserva, V, Muggiasca, M, Arrigoni, L, Mantegazza, V, Rossi, E, Ferrazzi, E. Recurrence and severity of abnormal pregnancy outcome in patients treated by low-molecular-weight heparin: a prospective pilot study. J Matern Fetal Neonatal Med 2012; 25 (8): 1467–73. Epub 2011/11/30.Google Scholar
21Sacks, GP, Studena, K, Sargent, K, Redman, CW. Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis. Am J Obstet Gynecol 1998; 179 (1): 80–6. Epub 1998/08/15.Google Scholar
22Smarason, AK, Gunnarsson, A, Alfredsson, JH, Valdimarsson, H. Monocytosis and monocytic infiltration of decidua in early pregnancy. J Clin Lab Immunol 1986; 21 (1): 1–5. Epub 1986/09/01.Google Scholar
23Austgulen, R, Lien, E, Liabakk, NB, Jacobsen, G, Arntzen, KJ. Increased levels of cytokines and cytokine activity modifiers in normal pregnancy. Eur J Obstet Gynecol Reprod Biol 1994; 57 (3): 149–55. Epub 1994/12/01.Google Scholar
24Gatti, L, Tenconi, PM, Guarneri, D, Bertulessi, C, Ossola, MW, Bosco, P, et al.Hemostatic parameters and platelet activation by flow-cytometry in normal pregnancy: a longitudinal study. Int J Clin Lab Res 1994; 24 (4): 217–19. Epub 1994/01/01.CrossRefGoogle ScholarPubMed
25Halligan, A, Bonnar, J, Sheppard, B, Darling, M, Walshe, J. Haemostatic, fibrinolytic and endothelial variables in normal pregnancies and pre-eclampsia. Br J Obstet Gynaecol. 1994; 101 (6): 488–92. Epub 1994/06/01.Google Scholar
26Haram, K, Augensen, K, Elsayed, S. Serum protein pattern in normal pregnancy with special reference to acute-phase reactants. Br J Obstet Gynaecol 1983; 90 (2): 139–45. Epub 1983/02/01.Google Scholar
27Studd, JW, Blainey, JD, Bailey, DE. Serum protein changes in the pre-eclampsia–eclampsia syndrome. JObstet Gynaecol Br Commonw 1970; 77 (9): 796–801. Epub 1970/09/01.Google Scholar
28Stanley, K, Fraser, R, Bruce, C. Physiological changes in insulin resistance in human pregnancy: longitudinal study with the hyperinsulinaemic euglycaemic clamp technique. Br J Obstet Gynaecol 1998; 105 (7): 756–59. Epub 1998/08/06.CrossRefGoogle ScholarPubMed
29Maynard, SE, Min, JY, Merchan, J, Lim, KH, Li, J, Mondal, S, et al.Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111 (5): 649–58. Epub 2003/03/06.Google Scholar
30Lee, SM, Romero, R, Lee, YJ, Park, IS, Park, CW, Yoon, BH. Systemic inflammatory stimulation by microparticles derived from hypoxic trophoblast as a model for inflammatory response in preeclampsia. Am J Obstet Gynecol 2012; 207 (4): 337 e1–8. Epub 2012/10/02.CrossRefGoogle Scholar
31WHO. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organization technical report series. 2000; 894: i–xii, 1–253. Epub 2001/03/10.Google Scholar
32Wood, LE. Obesity, waist–hip ratio and hunter-gatherers. BJOG 2006; 113 (10): 1110–16. Epub 2006/09/16.Google Scholar
33Despres, JP. Is visceral obesity the cause of the metabolic syndrome? Ann Med 2006; 38 (1): 52–63. Epub 2006/02/02.CrossRefGoogle ScholarPubMed
34Rosen, ED, Spiegelman, BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006; 444 (7121): 847–53. Epub 2006/12/15.Google Scholar
35Matsuzawa, Y, Funahashi, T, Nakamura, T. Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann N Y Acad Sci 1999; 892: 146–54. Epub 2000/06/08.Google Scholar
36Cote, M, Mauriege, P, Bergeron, J, Almeras, N, Tremblay, A, Lemieux, I, et al.Adiponectinemia in visceral obesity: impact on glucose tolerance and plasma lipoprotein and lipid levels in men. J Clin Endocrinol Metab 2005; 90 (3): 1434–39. Epub 2004/12/16.Google Scholar
37Suganami, T, Nishida, J, Ogawa, Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol. 2005; 25 (10): 2062–8. Epub 2005/08/27.Google Scholar
38Weisberg, SP, McCann, D, Desai, M, Rosenbaum, M, Leibel, RL, FerranteAW, Jr AW, Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112 (12):1796–808. Epub 2003/12/18.CrossRefGoogle ScholarPubMed
39Curat, CA, Miranville, A, Sengenes, C, Diehl, M, Tonus, C, Busse, R, et al.From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 2004; 53 (5): 1285–92. Epub 2004/04/28.CrossRefGoogle ScholarPubMed
40Cancello, R, Clement, K. Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG 2006; 113 (10): 1141–47. Epub 2006/08/15.CrossRefGoogle ScholarPubMed
41Xu, H, Barnes, GT, Yang, Q, Tan, G, Yang, D, Chou, CJ, et al.Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112 (12): 1821–30. Epub 2003/12/18.Google Scholar
42Grundy, SM, Brewer, HB Jr., Cleeman, JI, Smith, SC Jr., Lenfant, C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Arterioscler Thromb Vasc Biol 2004; 24 (2): e13–18. Epub 2004/02/10.Google Scholar
43Sohlberg, S, Stephansson, O, Cnattingius, S, Wikstrom, AK. Maternal body mass index, height, and risks of preeclampsia. Am J Hypertens 2012; 25 (1): 120–25. Epub 2011/10/07.Google Scholar
44Crispi, F, Llurba, E, Dominguez, C, Martin-Gallan, P, Cabero, L, Gratacos, E. Predictive value of angiogenic factors and uterine artery Doppler for early- versus late-onset pre-eclampsia and intrauterine growth restriction. Ultrasound Obstet Gynecol 2008; 31 (3): 303–9. Epub 2007/12/07.Google Scholar
45Mbah, AK, Kornosky, JL, Kristensen, S, August, EM, Alio, AP, Marty, PJ, et al. Super-obesity and risk for early and late pre-eclampsia BJOG 2010 Jul; 117 (8): 997–1004.Google Scholar
46Crispi, F, Dominguez, C, Llurba, E, Martin-Gallan, P, Cabero, L, Gratacos, E. Placental angiogenic growth factors and uterine artery Doppler findings for characterization of different subsets in preeclampsia and in isolated intrauterine growth restriction. Am J Obstet Gynecol 2006; 195 (1): 201–7. Epub 2006/03/21.CrossRefGoogle ScholarPubMed
47Mayhew, TM, Ohadike, C, Baker, PN, Crocker, IP, Mitchell, C, Ong, SS. Stereological investigation of placental morphology in pregnancies complicated by pre-eclampsia with and without intrauterine growth restriction. Placenta 2003; 24 (2–3): 219–26. Epub 2003/02/05.Google Scholar
48Valensise, H, Vasapollo, B, Gagliardi, G, Novelli, GP. Early and late preeclampsia: two different maternal hemodynamic states in the latent phase of the disease. Hypertension 2008; 52 (5): 873–80. Epub 2008/10/01.Google Scholar
49Nicholson, JK, Holmes, E, Kinross, J, Burcelin, R, Gibson, G, Jia, W, et al.Host-gut microbiota metabolic interactions. Science 2012; 336 (6086): 1262–67. Epub 2012/06/08.Google Scholar
50Hooper, LV, Littman, DR, Macpherson, AJ. Interactions between the microbiota and the immune system. Science 2012; 336 (6086): 1268–73. Epub 2012/06/08.Google Scholar
51Brantsaeter, AL, Myhre, R, Haugen, M, Myking, S, Sengpiel, V, Magnus, P, et al.Intake of probiotic food and risk of preeclampsia in primiparous women: the Norwegian Mother and Child Cohort Study. Am J Epidemiol 2011; 174 (7): 807–15. Epub 2011/08/09.Google Scholar
52Maynard, CL, Elson, CO, Hatton, RD, Weaver, CT. Reciprocal interactions of the intestinal microbiota and immune system. Nature 2012; 489 (7415): 231–41. Epub 2012/09/14.Google Scholar
53Bergen, NE, Jaddoe, VW, Timmermans, S, Hofman, A, Lindemans, J, Russcher, H, et al.Homocysteine and folate concentrations in early pregnancy and the risk of adverse pregnancy outcomes: the Generation R Study. BJOG 2012; 119 (6): 739–51. Epub 2012/04/12.Google Scholar
54Lamkanfi, M, Walle, LV, Kanneganti, TD. Deregulated inflammasome signaling in disease. Immunol Rev 2011; 243 (1): 163–73. Epub 2011/09/03.CrossRefGoogle ScholarPubMed