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Published online by Cambridge University Press: 15 December 2005
Reports in the 1970's by Snyder and others of opioid receptors in the brain and the substantia gelatinosa of the spinal cord triggered a search for endogenous opioid ligands (β-endorphin and the encephalin peptides) which might modify pain transmission. It was not long after that morphine was administered into the human epidural space for pain control, including obstetric patients.