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Targeting the molecular basis for tumour hypoxia

Published online by Cambridge University Press:  15 April 2005

Veronica A. Carroll  and
Margaret Ashcroft
Veronica A. Carroll
Affiliation:
Cell Growth Regulation and Angiogenesis Laboratory, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
Margaret Ashcroft
Affiliation:
Cell Growth Regulation and Angiogenesis Laboratory, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
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Abstract

Tumour hypoxia stems from impaired oxygen delivery as a result of a disorganised tumour vasculature and inadequate blood supply. Hypoxic tumours are highly resistant to chemotherapy and radiation therapy and correlate with a poor patient prognosis. Hypoxia is a powerful stimulus for the expression of genes involved in cell survival and angiogenesis. A key factor in this process is hypoxia-inducible factor (HIF), which regulates transcription of hypoxia-activated genes. Efforts are currently under way to develop targeted cancer therapeutics to hypoxia-activated pathways, and in particular to the transcription factor HIF.

Keywords

Tumour hypoxiaHIFtargeted cancer therapeuticsangiogenesis
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 7 , Issue 6 , 15 April 2005 , pp. 1 - 16
Copyright
© Cambridge University Press 2005

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