The role of macrophages in inflammatory bowel diseases

Sigrid E.M. Heinsbroek; Siamon Gordon

doi:10.1017/S1462399409001069

The role of macrophages in inflammatory bowel diseases

Published online by Cambridge University Press: 14 May 2009

Sigrid E.M. Heinsbroek and

Siamon Gordon

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Sigrid E.M. Heinsbroek*: Affiliation:
Department of Gastroenterology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Siamon Gordon: Affiliation:
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
*: *Corresponding author: Sigrid Heinsbroek, Department of Gastroenterology, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. Tel: +31 20 5664109; Fax: +31 20 6917033; E-mail: [email protected]

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Abstract

The small and large intestine contain the largest number of macrophages in the body and these cells are strategically located directly underneath the epithelial layer, enabling them to sample the lumen. Such intestinal macrophages have a different phenotype from other tissue macrophages in that they ingest and may kill microbes but they do not mediate strong pro-inflammatory responses upon microbial recognition. These properties are essential for maintaining a healthy intestine. It is generally accepted that tolerance to the intestinal flora is lost in inflammatory bowel diseases, and genes involved in microbial recognition, killing and macrophage activation have already been associated with these diseases. In this review, we shed light on the intestinal macrophage and how it influences intestinal immunity.

Type: Review Article
Information: Expert Reviews in Molecular Medicine , Volume 11 , July 2009 , e14

DOI: https://doi.org/10.1017/S1462399409001069 [Opens in a new window]
Copyright: Copyright © Cambridge University Press 2009

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