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Recent advances in understanding the molecular basis of group B Streptococcus virulence

Published online by Cambridge University Press:  22 September 2008

Heather C. Maisey ,
Kelly S. Doran  and
Victor Nizet
Heather C. Maisey
Affiliation:
Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Kelly S. Doran
Affiliation:
Department of Biology, San Diego State University, San Diego, CA, USA.
Victor Nizet*
Affiliation:
Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
*
*Corresponding author: Victor Nizet, Professor of Pediatrics and Pharmacy, University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences, 9500 Gilman Drive, La Jolla, CA 92093-0687, USA. Tel:  + 1 858 534 7408; Fax:  + 1 858 534 5611; E-mail: [email protected]
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Abstract

Group B Streptococcus commonly colonises healthy adults without symptoms, yet under certain circumstances displays the ability to invade host tissues, evade immune detection and cause serious invasive disease. Consequently, Group B Streptococcus remains a leading cause of neonatal pneumonia, sepsis and meningitis. Here we review recent information on the bacterial factors and mechanisms that direct host–pathogen interactions involved in the pathogenesis of Group B Streptococcus infection. New research on host signalling and inflammatory responses to Group B Streptococcus infection is summarised. An understanding of the complex interplay between Group B Streptococcus and host provides valuable insight into pathogen evolution and highlights molecular targets for therapeutic intervention.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 10 , October 2008 , e27
Copyright
Copyright © Cambridge University Press 2008

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References

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Further reading, resources and contacts

Clinical information on GBS infection can be found at the following websites:

Centers for Disease Control (USA):

http://www.cdc.gov/groupbstrep/Google Scholar
http://www.emedicine.com/Med/topic2185.htmGoogle Scholar
http://www.gbss.org.uk/Google Scholar
http://www.groupbstrep.org/Google Scholar
http://www.cdc.gov/groupbstrep/Google Scholar
http://www.emedicine.com/Med/topic2185.htmGoogle Scholar
http://www.gbss.org.uk/Google Scholar
http://www.groupbstrep.org/Google Scholar