Osteopontin in macrophage function

Susan R. Rittling

doi:10.1017/S1462399411001839

Osteopontin in macrophage function

Published online by Cambridge University Press: 26 April 2011

Susan R. Rittling

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Susan R. Rittling: Affiliation:
The Forsyth Institute, 245 First St, Cambridge, MA 02142, USA. E-mail: [email protected]

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Abstract

The secreted phosphorylated protein osteopontin (OPN) is expressed in a variety of tissues and bodily fluids, and is associated with pathologies including tissue injury, infection, autoimmune disease and cancer. Macrophages are ubiquitous, heterogeneous cells that mediate aspects of cell and tissue damage in all these pathologies. Here, the role of OPN in macrophage function is reviewed. OPN is expressed in macrophage cells in multiple pathologies, and the regulation of its expression in these cells has been described in vitro. The protein has been implicated in multiple functions of macrophages, including cytokine expression, expression of inducible nitric oxide synthase, phagocytosis and migration. Indeed, the role of OPN in cells of the macrophage lineage might underlie its physiological role in many pathologies. However, there are numerous instances where the published literature is inconsistent, especially in terms of OPN function in vitro. Although the heterogeneity of OPN and its receptors, or of macrophages themselves, might underlie some of these inconsistencies, it is important to understand the role of OPN in macrophage biology in order to exploit its function therapeutically.

Type: Review Article
Information: Expert Reviews in Molecular Medicine , Volume 13 , March 2011 , e15

DOI: https://doi.org/10.1017/S1462399411001839 [Opens in a new window]
Copyright: Copyright © Cambridge University Press 2011

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Osteopontin in macrophage function

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Osteopontin in macrophage function

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