Norovirus–host interaction: implications for disease control and prevention

Ming Tan; Xi Jiang

doi:10.1017/S1462399407000348

Norovirus–host interaction: implications for disease control and prevention

Published online by Cambridge University Press: 11 July 2007

Ming Tan and

Xi Jiang

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Ming Tan: Affiliation:
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA.
Xi Jiang*: Affiliation:
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA.
*: *Corresponding author: Xi Jiang, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH45229-3039, USA. Tel: +1 513 636 0119; Fax: +1 513 636 7655; E-mail: [email protected]

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Abstract

Noroviruses (NVs) are a major cause of acute gastroenteritis epidemics in both developing and developed countries and affect people of all ages. Three main human histo-blood group antigens (HBGAs) – the ABO, Lewis and secretor families – are involved in NV recognition and eight strain-specific receptor-binding patterns in two major binding groups have been described. The receptor-binding interface is located at the outermost surface of the P domain of the viral capsid. Each interface contains two major binding sites and each site interacts with a carbohydrate side-chain of the HBGAs via multiple hydrogen bonds. Soluble HBGAs in human milk are able to block binding of NV to HBGA receptors, suggesting a potential decoy receptor for the protection of infants from NV infection. Phylogenetic analysis has revealed limited genetic relatedness among NVs with similar receptor-binding patterns. This review summarises and discusses recent advances and highlights implications for future studies in the control and prevention of NV gastroenteritis.

Type: Review Article
Information: Expert Reviews in Molecular Medicine , Volume 9 , Issue 19 , July 2007 , pp. 1 - 22

DOI: https://doi.org/10.1017/S1462399407000348 [Opens in a new window]
Copyright: Copyright © Cambridge University Press 2007

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Norovirus–host interaction: implications for disease control and prevention

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