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Molecular pathogenesis and clinical implications of eczema herpeticum

Published online by Cambridge University Press:  14 July 2008

Caroline Bussmann ,
Wen-Ming Peng ,
Thomas Bieber  and
Natalija Novak
Caroline Bussmann
Affiliation:
Department of Dermatology and Allergology, University of Bonn, Bonn, Germany.
Wen-Ming Peng
Affiliation:
Department of Dermatology and Allergology, University of Bonn, Bonn, Germany.
Thomas Bieber
Affiliation:
Department of Dermatology and Allergology, University of Bonn, Bonn, Germany.
Natalija Novak*
Affiliation:
Department of Dermatology and Allergology, University of Bonn, Bonn, Germany.
*
*Corresponding author: Natalija Novak, Department of Dermatology and Allergology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. Tel: +49 228 287 15370; Fax: +49 228 287 14333; E-mail: [email protected]
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Abstract

A subgroup of patients with atopic dermatitis develops one or more episodes of a severe viral skin infection caused by herpes simplex virus superimposed on eczematous skin lesions. This condition is named atopic dermatitis complicated by eczema herpeticum. Characteristic features of patients developing eczema herpeticum include an early age of onset of atopic dermatitis with a persistent and severe course into adulthood, predilection for eczematous skin lesions in the head and neck area, elevated total serum IgE levels and increased allergen sensitisation. Deficiencies at the level of both the innate and the adaptive immune system, which have been identified in atopic dermatitis, are much more pronounced in this subgroup. Predisposing cellular factors include a reduced number of plasmacytoid dendritic cells in the epidermis and a modified capacity of these cells to produce type I interferons after allergen challenge. In addition, lower levels of antimicrobial peptides in the skin of atopic dermatitis patients, resulting in part from a Th2-prone micromilieu, contribute to the lack of an effective defence against viral attack. In this review, we summarise the current knowledge of the molecular pathogenesis of eczema herpeticum.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 10 , October 2008 , e21
Copyright
Copyright © Cambridge University Press 2008

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References

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Further reading, resources and contacts

Bieber, T. (2008) Atopic dermatitis. N Engl J Med 358, 1483-1494CrossRefGoogle ScholarPubMed
Reitamo, S., Luger, T. and Steinhoff, M. (2008) Textbook of Atopic Dermatitis. Informa Healthcare.CrossRefGoogle Scholar
Burns, T., Griffiths, C., Breathnach, S. and Cox, N. (2004) Rook's Textbook of Dermatology (7th edn), Blackwell.CrossRefGoogle Scholar
Bieber, T. (2008) Atopic dermatitis. N Engl J Med 358, 1483-1494CrossRefGoogle ScholarPubMed
Reitamo, S., Luger, T. and Steinhoff, M. (2008) Textbook of Atopic Dermatitis. Informa Healthcare.CrossRefGoogle Scholar
Burns, T., Griffiths, C., Breathnach, S. and Cox, N. (2004) Rook's Textbook of Dermatology (7th edn), Blackwell.CrossRefGoogle Scholar