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Haematopoietic stem cell transplantation: can our genes predict clinical outcome?

Published online by Cambridge University Press:  02 November 2007

Anne M. Dickinson ,
Jane L. Harrold  and
Hannah Cullup
Anne M. Dickinson*
Affiliation:
School of Clinical and Laboratory Sciences, Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, UK.
Jane L. Harrold
Affiliation:
School of Clinical and Laboratory Sciences, Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, UK.
Hannah Cullup
Affiliation:
School of Clinical and Laboratory Sciences, Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, UK.
*
*Corresponding author: Anne Dickinson, Institute of Cellular Medicine, School of Clinical and Laboratory Sciences, Newcastle upon Tyne, NE2 4HH, UK. Tel/Fax: +44 (0)191 222 6794; E-mail: [email protected]
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Abstract

Haematopoietic stem cell transplantation (HSCT) is currently the only curative treatment for many patients with malignant and non-malignant haematological diseases. The success of HSCT is greatly reduced by the development of complications, which include graft-versus-host disease (GVHD), relapse and infection. Human leukocyte antigen (HLA) matching of patients and donors is essential, but does not completely prevent these complications; non-HLA genes may also have an impact upon transplant outcome. Polymorphisms within genes that are associated with an individual's capability to mount an immune response to alloantigen and infectious pathogens and/or response to drugs (pharmacogenomics) are all currently being studied for their association with HSCT outcome. This review summarises the potential role of non-HLA polymorphisms in predicting HSCT outcome, from studies on retrospective transplant cohorts of HLA-identical siblings and matched unrelated donors. The clinical relevance and interpretation of non-HLA genetics, and how these could be used alongside clinical risk factors in HSCT, are also discussed.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 9 , Issue 29 , November 2007 , pp. 1 - 19
Copyright
Copyright © Cambridge University Press 2007

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References

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Further reading, resources and contacts

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Wysocki, C.A. et al. (2005) Leukocyte migration and graft-versus-host disease. Blood 105, 4191-4199CrossRefGoogle ScholarPubMed
Ruggeri, L. et al. (2006) Allogeneic hematopoietic transplantation and natural killer cell recognition of missing self. Immunol Rev 214, 202-218CrossRefGoogle ScholarPubMed