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Genetic factors underlying prostate cancer

Published online by Cambridge University Press:  13 February 2004

Jian-Hua Luo  and
Yan Ping Yu
Jian-Hua Luo
Affiliation:
Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA.
Yan Ping Yu
Affiliation:
Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA.
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Abstract

Prostate cancer is one of the leading causes of cancer-related death in the USA. In the past decade, tremendous progress has been made in the identification and understanding of the genetic factors related to prostate cancer development. Unlike many other types of cancers, only a small fraction of prostate cancer cases are aggressive and life-threatening. The factors related to prostate cancer development and progression appear complex and diverse. This review summarises some of the important findings in the areas of genome and gene expression abnormalities in prostate cancer, and aims to provide a comprehensive view of new developments in these areas.

Keywords

prostate cancergenomegene expressionchromosomemethylationhereditaryhigh-throughput analysismutation
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 5 , Issue 12 , 15 April 2003 , pp. 1 - 26
Copyright
© Cambridge University Press 2003

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