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Tissue engineering: TGF-β superfamily members and delivery systems in bone regeneration

Published online by Cambridge University Press:  13 February 2004

Lentsha N. Ramoshebi ,
Thato N. Matsaba ,
June Teare ,
Louise Renton ,
Janet Patton  and
Ugo Ripamonti
Lentsha N. Ramoshebi
Affiliation:
Bone Research Laboratory, Medical Research Council of South Africa and the University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.
Thato N. Matsaba
Affiliation:
Bone Research Laboratory, Medical Research Council of South Africa and the University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.
June Teare
Affiliation:
Bone Research Laboratory, Medical Research Council of South Africa and the University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.
Louise Renton
Affiliation:
Bone Research Laboratory, Medical Research Council of South Africa and the University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.
Janet Patton
Affiliation:
Bone Research Laboratory, Medical Research Council of South Africa and the University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.
Ugo Ripamonti
Affiliation:
Bone Research Laboratory, Medical Research Council of South Africa and the University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.
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Abstract

The induction of bone formation requires three parameters that interact in a highly regulated process: soluble osteoinductive signals, capable responding cells, and a supporting matrix substratum or insoluble signal. The use of recombinant and naturally derived bone morphogenetic proteins and transforming growth factor βs (TGF-βs) has increased our understanding of the functions of these morphogens during the induction of endochondral bone formation. In addition, growing understanding of the cellular interactions of living tissues with synthetic biomaterials has led to the in vivo induction of bone formation using porous biomimetic matrices as an alternative to the use of autografts for bone regeneration. This review outlines the basis of bone tissue engineering by members of the TGF-β superfamily, focusing on their delivery systems and the intrinsic induction of bone formation by specific biomimetic matrices with a defined geometry.

Keywords

osteogenesisbone inductiontissue engineeringbiomaterialsdelivery systembone morphogenetic proteinsBNPstransforming growth factor betaTGF-beta
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 4 , Issue 20 , 2 September 2002 , pp. 1 - 11
Copyright
© Cambridge University Press 2002

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