Role of chemokines in proteinuric kidney disorders

Juan Antonio Moreno; Sara Moreno; Alfonso Rubio-Navarro; Carmen Gómez-Guerrero; Alberto Ortiz; Jesús Egido

doi:10.1017/erm.2014.3

Role of chemokines in proteinuric kidney disorders

Published online by Cambridge University Press: 17 February 2014

Juan Antonio Moreno ,

Sara Moreno ,

Alfonso Rubio-Navarro ,

Carmen Gómez-Guerrero ,

Alberto Ortiz and

Jesús Egido

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Juan Antonio Moreno*: Affiliation:
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain
Sara Moreno: Affiliation:
Department of Biotechnology, INIA, Madrid, Spain
Alfonso Rubio-Navarro: Affiliation:
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain
Carmen Gómez-Guerrero: Affiliation:
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain
Alberto Ortiz: Affiliation:
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain Fundacion Renal Iñigo Alvarez de Toledo/Instituto Reina Sofia de Investigacion Nefrologica (FRIAT/IRSIN), Spain
Jesús Egido: Affiliation:
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain Fundacion Renal Iñigo Alvarez de Toledo/Instituto Reina Sofia de Investigacion Nefrologica (FRIAT/IRSIN), Spain Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain
*: *Corresponding author: Juan Antonio Moreno, IIS-Fundación Jiménez Díaz, Avda. Reyes Católicos 2, 28040 Madrid, Spain. E-mail: [email protected]

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Abstract

Experimental and human studies have shown that proteinuria contributes to the progression of renal disease. Overexposure to filtered proteins promotes the expression and release of chemokines by tubular epithelial cells, thus leading to inflammatory cell recruitment and renal impairment. This review focuses on recent progress in cellular and molecular understanding of the role of chemokines in the pathogenesis of proteinuria-induced renal injury, as well as their clinical implications and therapeutic potential.

Type: Review Article
Information: Expert Reviews in Molecular Medicine , Volume 16 , 2014 , e3

DOI: https://doi.org/10.1017/erm.2014.3 [Opens in a new window]
Copyright: Copyright © Cambridge University Press 2014

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Role of chemokines in proteinuric kidney disorders

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