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Preclinical models of atherosclerosis. The future of Hybrid PET/MR technology for the early detection of vulnerable plaque

Published online by Cambridge University Press:  08 April 2016

Irene Cuadrado ,
Marta Saura ,
Borja Castejón ,
Ana María Martin ,
Irene Herruzo ,
Nikolaos Balatsos ,
Jose Luis Zamorano  and
Carlos Zaragoza
Irene Cuadrado
Affiliation:
Departmentof Physiology, University of Alcala, School of Medicine, Ctra Madrid Barcelona, Km 3,300, 28875 Alcala de Henares, Madrid, Spain
Marta Saura
Affiliation:
Departmentof Physiology, University of Alcala, School of Medicine, Ctra Madrid Barcelona, Km 3,300, 28875 Alcala de Henares, Madrid, Spain
Borja Castejón
Affiliation:
Cardiology Department, University Francisco de Vitoria/Hospital Ramón y Cajal, Ctra. Colmenar Viejo, km 9,100, 28034 Madrid, Spain
Ana María Martin
Affiliation:
Cardiology Department, University Francisco de Vitoria/Hospital Ramón y Cajal, Ctra. Colmenar Viejo, km 9,100, 28034 Madrid, Spain
Irene Herruzo
Affiliation:
Cardiology Department, University Francisco de Vitoria/Hospital Ramón y Cajal, Ctra. Colmenar Viejo, km 9,100, 28034 Madrid, Spain
Nikolaos Balatsos
Affiliation:
Department of Biochemistry and Biotechnology, University of Thessaly, Ploutonos 26, 412 21 Larissa, Greece
Jose Luis Zamorano
Affiliation:
Cardiology Department, University Francisco de Vitoria/Hospital Ramón y Cajal, Ctra. Colmenar Viejo, km 9,100, 28034 Madrid, Spain
Carlos Zaragoza*
Affiliation:
Cardiology Department, University Francisco de Vitoria/Hospital Ramón y Cajal, Ctra. Colmenar Viejo, km 9,100, 28034 Madrid, Spain
*
*Corresponding author: Carlos Zaragoza, Cardiology Department, University Francisco de Vitoria/Hospital Ramón y Cajal, Ctra. Colmenar Viejo, km 9,100, 28034 Madrid, Spain. E-mail: [email protected]
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Abstract

Cardiovascular diseases are the leading cause of death in developed countries. The aetiology is currently multifactorial, thus making them very difficult to prevent. Preclinical models of atherothrombotic diseases, including vulnerable plaque-associated complications, are now providing significant insights into pathologies like atherosclerosis, and in combination with the most recent advances in new non-invasive imaging technologies, they have become essential tools to evaluate new therapeutic strategies, with which can forecast and prevent plaque rupture. Positron emission tomography (PET)/computed tomography imaging is currently used for plaque visualisation in clinical and pre-clinical cardiovascular research, albeit with significant limitations. However, the combination of PET and magnetic resonance imaging (MRI) technologies is still the best option available today, as combined PET/MRI scans provide simultaneous data acquisition together with high quality anatomical information, sensitivity and lower radiation exposure for the patient. The coming years may represent a new era for the implementation of PET/MRI in clinical practice, but first, clinically efficient attenuation correction algorithms and research towards multimodal reagents and safety issues should be validated at the preclinical level.

Type
Review
Information
Expert Reviews in Molecular Medicine , Volume 18 , 2016 , e6
Copyright
Copyright © Cambridge University Press 2016 

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