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Molecular mechanisms underlying nutrient-stimulated incretin secretion

Published online by Cambridge University Press:  05 January 2010

Helen E. Parker ,
Frank Reimann  and
Fiona M. Gribble
Helen E. Parker
Affiliation:
Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, CB2 0XY, UK.
Frank Reimann
Affiliation:
Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, CB2 0XY, UK.
Fiona M. Gribble*
Affiliation:
Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, CB2 0XY, UK.
*
*Corresponding author: Fiona M. Gribble, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0XY, UK. E-mail: [email protected]
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Abstract

The incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released from enteroendocrine cells in the intestinal epithelium in response to nutrient ingestion. The actions of GLP-1 and GIP – not only on local gut physiology but also on glucose homeostasis, appetite control and fat metabolism – have made these hormones an attractive area for drug discovery programmes. The potential range of strategies to target the secretion of these hormones therapeutically has been limited by an incomplete understanding of the mechanisms underlying their release. The use of organ and whole-animal perfusion techniques, cell line models and primary L- and K-cells has led to the identification of a variety of pathways involved in the sensing of carbohydrate, fat and protein in the gut lumen. This review focuses on our current understanding of these signalling mechanisms that might underlie nutrient responsiveness of L- and K-cells.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 12 , January 2010 , e1
Copyright
Copyright © Cambridge University Press 2010

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References

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Further reading, resources and contacts

Holst, J.J. (2007) The physiology of glucagon-like peptide 1. Physiological Reviews 87, 1409-1439Google Scholar
http://www.glucagon.com/Google Scholar