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Glycerol-3-phosphate acyltransferases and metabolic syndrome: recent advances and future perspectives

Published online by Cambridge University Press:  05 September 2022

Yinqiong Huang Open the ORCID record for Yinqiong Huang [Opens in a new window] ,
Keyue Hu ,
Shu Lin Open the ORCID record for Shu Lin [Opens in a new window]  and
Xiahong Lin
Yinqiong Huang
Affiliation:
Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Keyue Hu
Affiliation:
Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Shu Lin*
Affiliation:
Centre of Neurological and Metabolic Research, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China Diabetes and Metabolism Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
Xiahong Lin
Affiliation:
Department of endocrinology, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China
*
Author for correspondence: Shu Lin, E-mail: [email protected]
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Abstract

Triglycerol-3-phosphate acyltransferases (GPATs) are the key enzymes in the first step of the synthesis of triacylglycerol (TAG). In mammals, there are four isoforms of GPATs. GPAT1 and GPAT2 are localised in the outer mitochondrial membrane, while GPAT3 and GPAT4 are localised in the endoplasmic reticulum. Previous research has emphasised that GPAT plays a critical effect on the development of metabolic syndromes, such as liver steatosis, obesity, and insulin resistance. In this review, we will critically evaluate the regulatory effects of GPATs isoforms in metabolic syndrome. In addition, we also discuss perspectives on clinical intervention strategies for the neurometabolic disease.

Keywords

Glycerol-3-phosphate acyltransferasesinsulin resistancemetabolic syndromeobesitytriacylglycerol
Type
Review
Information
Expert Reviews in Molecular Medicine , Volume 24 , 2022 , e30
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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