Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-27T03:24:27.243Z Has data issue: false hasContentIssue false
  • English
  • Français

Designer functionalised self-assembling peptide nanofibre scaffolds for cartilage tissue engineering

Published online by Cambridge University Press:  04 August 2014

Bin He ,
Xiao Yuan ,
Aiguo Zhou ,
Hua Zhang  and
Dianming Jiang
Bin He
Affiliation:
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Xiao Yuan
Affiliation:
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Aiguo Zhou
Affiliation:
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Hua Zhang
Affiliation:
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Dianming Jiang*
Affiliation:
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
*
*Corresponding author:D. Jiang, No. 1 Yi Xue Yuan Road, Yuzhong District, Chongqing, 400016, China. Tel: 008689011212; Fax: 008689011212; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Owing to the limited regenerative capacity of cartilage tissue, cartilage repair remains a challenge in clinical treatment. Tissue engineering has emerged as a promising and important approach to repair cartilage defects. It is well known that material scaffolds are regarded as a fundamental element of tissue engineering. Novel biomaterial scaffolds formed by self-assembling peptides consist of nanofibre networks highly resembling natural extracellular matrices, and their fabrication is based on the principle of molecular self-assembly. Indeed, peptide nanofibre scaffolds have obtained much progress in repairing various damaged tissues (e.g. cartilage, bone, nerve, heart and blood vessel). This review outlines the rational design of peptide nanofibre scaffolds and their potential in cartilage tissue engineering.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 16 , 2014 , e12
Copyright
Copyright © Cambridge University Press 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Hendriks, J., Riesle, J. and van Blitterswijk, C.A. (2007) Co-culture in cartilage tissue engineering. Journal of Tissue Engineering and Regenerative Medicine 1, 170-178CrossRefGoogle ScholarPubMed
2Mano, J.F. and Reis, R.L. (2007) Osteochondral defects: present situation and tissue engineering approaches. Journal of Tissue Engineering and Regenerative Medicine 1, 261-273CrossRefGoogle ScholarPubMed
3Swieszkowski, W. et al. (2007) Repair and regeneration of osteochondral defects in the articular joints. Biomolecular Engineering 24, 489-495CrossRefGoogle ScholarPubMed
4Reddi, A.H., Becerra, J. and Andrades, J.A. (2011) Nanomaterials and hydrogel scaffolds for articular cartilage regeneration. Tissue Engineering Part B Reviews 17, 301-305CrossRefGoogle ScholarPubMed
5Bovee, J.V. et al. (2010) Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nature Reviews Cancer 10, 481-488CrossRefGoogle ScholarPubMed
6Cully, M. (2013) Regenerative medicine: adhesive-hydrogel composite developed to repair damaged cartilage. Nature Reviews Rheumatology 9, 135CrossRefGoogle ScholarPubMed
7Block, J.A. (2014) Osteoarthritis: OA guidelines: improving care or merely codifying practice? Nature Reviews Rheumatology 10, 324-326.CrossRefGoogle ScholarPubMed
8Firestein, G.S. (2003) Evolving concepts of rheumatoid arthritis. Nature 423, 356-361CrossRefGoogle ScholarPubMed
9Benders, K.E. et al. (2013) Extracellular matrix scaffolds for cartilage and bone regeneration. Trends in Biotechnology 31, 169-176CrossRefGoogle ScholarPubMed
10Chung, C. and Burdick, J.A. (2008) Engineering cartilage tissue. Advanced Drug Delivery Reviews 60, 243-262CrossRefGoogle ScholarPubMed
11Ouzzine, M., Venkatesan, N. and Fournel-Gigleux, S. (2012) Proteoglycans and cartilage repair. Methods in Molecular Biology 836, 339-355CrossRefGoogle ScholarPubMed
12Ateshian, G.A. (2007) Artificial cartilage: weaving in three dimensions. Nature Materials 6, 89-90CrossRefGoogle ScholarPubMed
13Temenoff, J.S. and Mikos, A.G. (2000) Review: tissue engineering for regeneration of articular cartilage. Biomaterials 21, 431-440CrossRefGoogle ScholarPubMed
14Ochi, M. et al. (2001) Current concepts in tissue engineering technique for repair of cartilage defect. Artificial Organs 25, 172-179CrossRefGoogle ScholarPubMed
15Panseri, S. et al. (2012) Osteochondral tissue engineering approaches for articular cartilage and subchondral bone regeneration. Knee Surgery Sports Traumatology Arthroscopy 20, 1182-1191CrossRefGoogle ScholarPubMed
16Gomoll, A.H. et al. (2010) The subchondral bone in articular cartilage repair: current problems in the surgical management. Knee Surgery Sports Traumatology Arthroscopy 18, 434-447CrossRefGoogle ScholarPubMed
17Handorf, A.M. and Li, W.J. (2014) Induction of mesenchymal stem cell chondrogenesis through sequential administration of growth factors within specific temporal windows. Journal of Cellular Physiology 229, 162-171CrossRefGoogle ScholarPubMed
18He, B., Xiao, Y. and Jiang, D. (2014) Molecular self-assembly guides the fabrication of peptide nanofiber scaffolds for nerve repair. RSC Advances 4, 23610-23621.CrossRefGoogle Scholar
19Lutolf, M.P. and Hubbell, J.A. (2005) Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nature Biotechnology 23, 47-55CrossRefGoogle ScholarPubMed
20Place, E.S., Evans, N.D. and Stevens, M.M. (2009) Complexity in biomaterials for tissue engineering. Nature Materials 8, 457-470CrossRefGoogle ScholarPubMed
21Hosseinkhani, H., Hosseinkhani, M. and Kobayashi, H. (2006) Design of tissue-engineered nanoscaffold through self-assembly of peptide amphiphile. Journal of Bioactive and Compatible Polymers 21, 277-296CrossRefGoogle Scholar
22Freed, L.E. et al. (2006) Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling. Tissue Engineering 12, 3285-3305CrossRefGoogle ScholarPubMed
23Dvir, T. et al. (2011) Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology 6, 13-22CrossRefGoogle ScholarPubMed
24Tuan, R.S. (2013) Regenerative medicine in 2012: the coming of age of musculoskeletal tissue engineering. Nature Reviews Rheumatology 9, 74-76CrossRefGoogle ScholarPubMed
25Ebihara, G. et al. (2012) Cartilage repair in transplanted scaffold-free chondrocyte sheets using a minipig model. Biomaterials 33, 3846-3851CrossRefGoogle ScholarPubMed
26Kokemueller, H. et al. (2010) Prefabrication of vascularized bioartificial bone grafts in vivo for segmental mandibular reconstruction: experimental pilot study in sheep and first clinical application. International Journal of Oral and Maxillofacial Surgery 39, 379-387CrossRefGoogle ScholarPubMed
27Hosseinkhani, H. et al. (2007) Bone regeneration on a collagen sponge self-assembled peptide-amphiphile nanofiber hybrid scaffold. Tissue Engineering 13, 11-19CrossRefGoogle ScholarPubMed
28Kehoe, S., Zhang, X.F. and Boyd, D. (2012) FDA approved guidance conduits and wraps for peripheral nerve injury: a review of materials and efficacy. Injury 43, 553-572CrossRefGoogle ScholarPubMed
29Segers, V.F. and Lee, R.T. (2011) Biomaterials to enhance stem cell function in the heart. Circulation Research 109, 910-922CrossRefGoogle ScholarPubMed
30Dolgin, E. (2011) Taking tissue engineering to heart. Nature Medicine 17, 1032-1035CrossRefGoogle ScholarPubMed
31Drewa, T., Adamowicz, J. and Sharma, A. (2012) Tissue engineering for the oncologic urinary bladder. Nature Reviews Urology 9, 561-572CrossRefGoogle ScholarPubMed
32Kropp, B.P. and Zwischenberger, J.B. (2006) Tissue-engineered autologous bladders: new possibilities for cystoplasty. Nature Clinical Practice Urology 3, 588-589CrossRefGoogle ScholarPubMed
33Kopesky, P.W. et al. (2010) Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells. Tissue Engineering Part A 16, 465-477CrossRefGoogle ScholarPubMed
34Kisiday, J.D. et al. (2008) Evaluation of adult equine bone marrow- and adipose-derived progenitor cell chondrogenesis in hydrogel cultures. Journal of Orthopaedic Research 26, 322-331CrossRefGoogle ScholarPubMed
35Shah, R.N. et al. (2010) Supramolecular design of self-assembling nanofibers for cartilage regeneration. Proceedings of the National Academy of Sciences of the United States of America 107, 3293-3298CrossRefGoogle ScholarPubMed
36Zhang, S. (2003) Fabrication of novel biomaterials through molecular self-assembly. Nature Biotechnology 21, 1171-1178CrossRefGoogle ScholarPubMed
37Loo, Y., Zhang, S. and Hauser, C.A. (2012) From short peptides to nanofibers to macromolecular assemblies in biomedicine. Biotechnology Advances 30, 593-603CrossRefGoogle ScholarPubMed
38Zhao, X. and Zhang, S. (2006) Molecular designer self-assembling peptides. Chemical Society Reviews 35, 1105-1110CrossRefGoogle ScholarPubMed
39Hartgerink, J.D., Beniash, E. and Stupp, S.I. (2002) Peptide-amphiphile nanofibers: a versatile scaffold for the preparation of self-assembling materials. Proceedings of the National Academy of Sciences of the United States of America 99, 5133-5138CrossRefGoogle ScholarPubMed
40Hosseinkhani, H., Hong, P.D. and Yu, D.S. (2013) Self-assembled proteins and peptides for regenerative medicine. Chemical Reviews 113, 4837-4861CrossRefGoogle ScholarPubMed
41Cui, H., Webber, M.J. and Stupp, S.I. (2010) Self-assembly of peptide amphiphiles: from molecules to nanostructures to biomaterials. Biopolymers 94, 1-18CrossRefGoogle ScholarPubMed
42Matson, J.B. and Stupp, S.I. (2012) Self-assembling peptide scaffolds for regenerative medicine. Chemical Communications (Camb) 48, 26-33CrossRefGoogle ScholarPubMed
43Stephanopoulos, N., Ortony, J.H. and Stupp, S.I. (2013) Self-assembly for the synthesis of functional biomaterials. Acta Materialia 61, 912-930CrossRefGoogle ScholarPubMed
44Zhang, S. et al. (1993) Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane. Proceedings of the National Academy of Sciences of the United States of America 90, 3334-3338CrossRefGoogle Scholar
45Gelain, F., Horii, A. and Zhang, S. (2007) Designer self-assembling peptide scaffolds for 3-D tissue cell cultures and regenerative medicine. Macromolecular Bioscience 7, 544-551CrossRefGoogle ScholarPubMed
46Hartgerink, J.D., Beniash, E. and Stupp, S.I. (2001) Self-assembly and mineralization of peptide-amphiphile nanofibers. Science 294, 1684-1688CrossRefGoogle ScholarPubMed
47Hosseinkhani, H. et al. (2006) Ectopic bone formation in collagen sponge self-assembled peptide-amphiphile nanofibers hybrid scaffold in a perfusion culture bioreactor. Biomaterials 27, 5089-5098CrossRefGoogle Scholar
48Schneider, J.P. et al. (2002) Responsive hydrogels from the intramolecular folding and self-assembly of a designed peptide. Journal of the American Chemical Society 124, 15030-15037CrossRefGoogle ScholarPubMed
49Pochan, D.J. et al. (2003) Thermally reversible hydrogels via intramolecular folding and consequent self-assembly of a de novo designed peptide. Journal of the American Chemical Society 125, 11802-11803CrossRefGoogle ScholarPubMed
50Collier, J.H. and Messersmith, P.B. (2003) Enzymatic modification of self-assembled peptide structures with tissue transglutaminase. Bioconjugate Chemistry 14, 748-755CrossRefGoogle ScholarPubMed
51Jung, J.P., et al. (2008) Modulating the mechanical properties of self-assembled peptide hydrogels via native chemical ligation. Biomaterials 29, 2143-2151CrossRefGoogle ScholarPubMed
52Dong, H. et al. (2007) Self-assembly of multidomain peptides: balancing molecular frustration controls conformation and nanostructure. Journal of the American Chemical Society 129, 12468-12472CrossRefGoogle ScholarPubMed
53Aulisa, L., Dong, H. and Hartgerink, J.D. (2009) Self-assembly of multidomain peptides: sequence variation allows control over cross-linking and viscoelasticity. Biomacromolecules 10, 2694-2698CrossRefGoogle ScholarPubMed
54Zhao, F., Ma, M.L. and Xu, B. (2009) Molecular hydrogels of therapeutic agents. Chemical Society Reviews 38, 883-891CrossRefGoogle ScholarPubMed
55Gazit, E. (2007) Self-assembled peptide nanostructures: the design of molecular building blocks and their technological utilization. Chemical Society Reviews 36, 1263-1269CrossRefGoogle ScholarPubMed
56Ulijn, R.V. and Smith, A.M. (2008) Designing peptide based nanomaterials. Chemical Society Reviews 37, 664-675CrossRefGoogle ScholarPubMed
57Hosseinkhani, H., Kobayashi, H. and Tabata, Y. (2006) Design of tissue-engineered nano-scaffold using peptide amphiphile for regenerative medicine. Peptide Science 2005, 341-344Google Scholar
58Hosseinkhani, H., Hosseinkhani, M. and Khademhosseini, A. (2006) Tissue regeneration through self-assembled peptide amphiphile nanofibers. Yakhte Medical Journal 8, 204-209Google Scholar
59Holmes, T.C. et al. (2000) Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Proceedings of the National Academy of Sciences of the United States of America 97, 6728-6733CrossRefGoogle ScholarPubMed
60Schneider, A., Garlick, J.A. and Egles, C. (2008) Self-assembling peptide nanofiber scaffolds accelerate wound healing. PLoS ONE 3, e1410CrossRefGoogle ScholarPubMed
61Guo, H.D. et al. (2010) Transplantation of marrow-derived cardiac stem cells carried in designer self-assembling peptide nanofibers improves cardiac function after myocardial infarction. Biochemical and Biophysical Research Communications 399, 42-48CrossRefGoogle ScholarPubMed
62Yoshimi, R. et al. (2009) Self-assembling peptide nanofiber scaffolds, platelet-rich plasma, and mesenchymal stem cells for injectable bone regeneration with tissue engineering. Journal of Craniofacial Surgery 20, 1523-1530CrossRefGoogle ScholarPubMed
63Kisiday, J. et al. (2002) Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proceedings of the National Academy of Sciences of the United States of America 99, 9996-10001CrossRefGoogle ScholarPubMed
64Liu, J. et al. (2010) Self-assembly-peptide hydrogels as tissue-engineering scaffolds for three-dimensional culture of chondrocytes in vitro. Macromolecular Bioscience 10, 1164-1170CrossRefGoogle ScholarPubMed
65Tysseling-Mattiace, V.M. et al. (2008) Self-assembling nanofibers inhibit glial scar formation and promote axon elongation after spinal cord injury. Journal of Neuroscience 28, 3814-3823CrossRefGoogle ScholarPubMed
66Okada, S. et al. (2006) Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nature Medicine 12, 829-834CrossRefGoogle ScholarPubMed
67Kyle, S. et al. (2010) Recombinant self-assembling peptides as biomaterials for tissue engineering. Biomaterials 31, 9395-9405CrossRefGoogle ScholarPubMed
68Zhou, M. et al. (2009) Self-assembled peptide-based hydrogels as scaffolds for anchorage-dependent cells. Biomaterials 30, 2523-2530CrossRefGoogle ScholarPubMed
69Jackson, R.W. and Dieterichs, C. (2003) The results of arthroscopic lavage and debridement of osteoarthritic knees based on the severity of degeneration: a 4- to 6-year symptomatic follow-up. Arthroscopy 19, 13-20CrossRefGoogle ScholarPubMed
70Shannon, F.J. et al. (2001) Short-term benefit of arthroscopic washout in degenerative arthritis of the knee. International Orthopaedics 25, 242-245CrossRefGoogle ScholarPubMed
71Kon, E. et al. (2012) ACI and MACI. Journal of Knee Surgery 25, 17-22Google ScholarPubMed
72Marlovits, S. et al. (2006) Cartilage repair: generations of autologous chondrocyte transplantation. European Journal of Radiology 57, 24-31CrossRefGoogle ScholarPubMed
73Zheng, M.H. et al. (2007) Matrix-induced autologous chondrocyte implantation (MACI): biological and histological assessment. Tissue Engineering 13, 737-746CrossRefGoogle ScholarPubMed
74Hangody, L. et al. (1998) Mosaicplasty for the treatment of articular cartilage defects: application in clinical practice. Orthopedics 21, 751-756CrossRefGoogle ScholarPubMed
75Raub, C.B. et al. (2013) Microstructural remodeling of articular cartilage following defect repair by osteochondral autograft transfer. Osteoarthritis Cartilage 21, 860-868CrossRefGoogle ScholarPubMed
76Bugbee, W., Cavallo, M. and Giannini, S. (2012) Osteochondral allograft transplantation in the knee. Journal of Knee Surgery 25, 109-116Google ScholarPubMed
77Steadman, J.R., Rodkey, W.G. and Briggs, K.K. (2002) Microfracture to treat full-thickness chondral defects: surgical technique, rehabilitation, and outcomes. Journal of Knee Surgery 15, 170-176Google ScholarPubMed
78Clair, B.L., Johnson, A.R. and Howard, T. (2009) Cartilage repair: current and emerging options in treatment. Foot Ankle Specialist 2, 179-188CrossRefGoogle ScholarPubMed
79Ahmed, T.A. and Hincke, M.T. (2010) Strategies for articular cartilage lesion repair and functional restoration. Tissue Engineering Part B Reviews 16, 305-329CrossRefGoogle ScholarPubMed
80Huey, D.J., Hu, J.C. and Athanasiou, K.A. (2012) Unlike bone, cartilage regeneration remains elusive. Science 338, 917-921CrossRefGoogle ScholarPubMed
81Mithoefer, K. et al. (2009) Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence-based systematic analysis. American Journal of Sports Medicine 37, 2053-2063CrossRefGoogle ScholarPubMed
82Dhinsa, B.S. and Adesida, A.B. (2012) Current clinical therapies for cartilage repair, their limitation and the role of stem cells. Current Stem Cell Research Therapy 7, 143-148CrossRefGoogle ScholarPubMed
83Vinatier, C. et al. (2009) Cartilage engineering: a crucial combination of cells, biomaterials and biofactors. Trends in Biotechnology 27, 307-314CrossRefGoogle ScholarPubMed
84Chen, W.C. et al. (2011) Evaluating osteochondral defect repair potential of autologous rabbit bone marrow cells on type II collagen scaffold. Cytotechnology 63, 13-23CrossRefGoogle ScholarPubMed
85Shin, H., Olsen, B.D. and Khademhosseini, A. (2012) The mechanical properties and cytotoxicity of cell-laden double-network hydrogels based on photocrosslinkable gelatin and gellan gum biomacromolecules. Biomaterials 33, 3143-3152CrossRefGoogle ScholarPubMed
86Ahmed, T.A. et al. (2011) Fibrin glues in combination with mesenchymal stem cells to develop a tissue-engineered cartilage substitute. Tissue Engineering Part A 17, 323-335CrossRefGoogle ScholarPubMed
87Schmidt, J.J., Jeong, J. and Kong, H. (2011) The interplay between cell adhesion cues and curvature of cell adherent alginate microgels in multipotent stem cell culture. Tissue Engineering Part A 17, 2687-2694CrossRefGoogle ScholarPubMed
88Bougault, C. et al. (2012) Dynamic compression of chondrocyte-agarose constructs reveals new candidate mechanosensitive genes. PLoS ONE 7, 17CrossRefGoogle ScholarPubMed
89Jayakumar, R. et al. (2011) Biomaterials based on chitin and chitosan in wound dressing applications. Biotechnology Advances 29, 322-337CrossRefGoogle ScholarPubMed
90Chen, C.H. et al. (2013) Hyaluronan enhances bone marrow cell therapy for myocardial repair after infarction. Molecular Therapy 21, 670-679CrossRefGoogle ScholarPubMed
91Oshima, Y. et al. (2009) Variation of mesenchymal cells in polylactic acid scaffold in an osteochondral repair model. Tissue Engineering Part C Methods 15, 595-604CrossRefGoogle Scholar
92Nair, L.S. and Laurencin, C.T. (2007) Biodegradable polymers as biomaterials. Progress in Polymer Science 32, 762-798CrossRefGoogle Scholar
93Jeong, C.G., Zhang, H. and Hollister, S.J. (2012) Three-dimensional polycaprolactone scaffold-conjugated bone morphogenetic protein-2 promotes cartilage regeneration from primary chondrocytes in vitro and in vivo without accelerated endochondral ossification. Journal of Biomedical Materials Research Part A 100, 2088-2096CrossRefGoogle ScholarPubMed
94Endres, M. et al. (2012) An ovine in vitro model for chondrocyte-based scaffold-assisted cartilage grafts. Journal of Orthopaedic Surgery and Research 7, 37CrossRefGoogle ScholarPubMed
95Hsu, S.H. et al. (2006) Evaluation of biodegradable polyesters modified by type II collagen and Arg-Gly-Asp as tissue engineering scaffolding materials for cartilage regeneration. Artificial Organs 30, 42-55CrossRefGoogle ScholarPubMed
96Lee, S.H. and Shin, H. (2007) Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering. Advanced Drug Delivery Reviews 59, 339-359CrossRefGoogle ScholarPubMed
97Capito, R.M. and Spector, M. (2003) Scaffold-based articular cartilage repair. IEEE Engineering in Medicine and Biology Magazine 22, 42-50CrossRefGoogle ScholarPubMed
98Getgood, A. et al. (2009) Articular cartilage tissue engineering: today's research, tomorrow's practice? Journal of Bone and Joint Surgery – British Volume 91, 565-576CrossRefGoogle ScholarPubMed
99Hartgerink, J.D., Zubarev, E.R. and Stupp, S.I. (2001) Supramolecular one-dimensional objects. Current Opinion in Solid State and Materials Science 5, 355-361CrossRefGoogle Scholar
100Yanlian, Y. et al. (2009) Designer self-assembling peptide nanomaterials. Nano Today 4, 193-210CrossRefGoogle Scholar
101Hauser, C.A. and Zhang, S. (2010) Designer self-assembling peptide nanofiber biological materials. Chemical Society Reviews 39, 2780-2790CrossRefGoogle ScholarPubMed
102Zhang, S. (2002) Emerging biological materials through molecular self-assembly. Biotechnology Advances 20, 321-339CrossRefGoogle ScholarPubMed
103Caplan, M.R. et al. (2002) Control of self-assembling oligopeptide matrix formation through systematic variation of amino acid sequence. Biomaterials 23, 219-227CrossRefGoogle ScholarPubMed
104Chen, P. (2005) Self-assembly of ionic-complementary peptides: a physicochemical viewpoint. Colloids and Surfaces A: Physicochemical and Engineering Aspects 261, 3-24CrossRefGoogle Scholar
105Luo, Z., Zhao, X. and Zhang, S. (2008) Structural dynamic of a self-assembling peptide d-EAK16 made of only D-amino acids. PLoS One 3, e2364CrossRefGoogle ScholarPubMed
106Yokoi, H., Kinoshita, T. and Zhang, S. (2005) Dynamic reassembly of peptide RADA16 nanofiber scaffold. Proceedings of the National Academy of Sciences of the United States of America 102, 8414-8419CrossRefGoogle ScholarPubMed
107Gelain, F., Horii, A. and Zhang, S. (2007) Designer self-assembling peptide scaffolds for 3-d tissue cell cultures and regenerative medicine. Macromolecular Bioscience 7, 544-551CrossRefGoogle ScholarPubMed
108Luo, Z., Wang, S. and Zhang, S. (2011) Fabrication of self-assembling D-form peptide nanofiber scaffold d-EAK16 for rapid hemostasis. Biomaterials 32, 2013-2020CrossRefGoogle ScholarPubMed
109Matson, J.B., Zha, R.H. and Stupp, S.I. (2011) Peptide self-assembly for crafting functional biological materials. Current Opinion in Solid State and Materials Science 15, 225-235CrossRefGoogle ScholarPubMed
110Hosseinkhani, H. et al. (2006) Osteogenic differentiation of mesenchymal stem cells in self-assembled peptide-amphiphile nanofibers. Biomaterials 27, 4079-4086CrossRefGoogle ScholarPubMed
111Hosseinkhani, H., Hosseinkhani, M. and Kobayashi, H. (2006) Proliferation and differentiation of mesenchymal stem cells using self-assembled peptide amphiphile nanofibers. Biomedical Materials 1, 8-15CrossRefGoogle ScholarPubMed
112Jung, J.P. et al. (2009) Co-assembling peptides as defined matrices for endothelial cells. Biomaterials 30, 2400-2410CrossRefGoogle ScholarPubMed
113Jayawarna, V. et al. (2009) Introducing chemical functionality in Fmoc-peptide gels for cell culture. Acta Biomaterialia 5, 934-943CrossRefGoogle ScholarPubMed
114Chen, J.L. et al. (2014) Extracellular matrix production in vitro in cartilage tissue engineering. Stem Cells 8, 14-15Google Scholar
115Friedl, P. et al. (2012) New dimensions in cell migration. Nature Reviews Molecular Cell Biology 13, 743-747CrossRefGoogle ScholarPubMed
116Nelson, C.M. and Bissell, M.J. (2006) Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. Annual Review of Cell and Developmental Biology 22, 287-309CrossRefGoogle ScholarPubMed
117Hynes, R.O. (2009) The extracellular matrix: not just pretty fibrils. Science 326, 1216-1219CrossRefGoogle Scholar
118Baumann, K. (2012) Stem cells: holding tight onto the niche. Nature Reviews Molecular Cell Biology 13, 278-279Google Scholar
119Branco, M.C. et al. (2009) Macromolecular diffusion and release from self-assembled beta-hairpin peptide hydrogels. Biomaterials 30, 1339-1347CrossRefGoogle ScholarPubMed
120Koutsopoulos, S. et al. (2009) Controlled release of functional proteins through designer self-assembling peptide nanofiber hydrogel scaffold. Proceedings of the National Academy of Sciences of the United States of America 106, 4623-4628CrossRefGoogle ScholarPubMed
121Woerly, S. et al. (2001) Spinal cord repair with PHPMA hydrogel containing RGD peptides (NeuroGel). Biomaterials 22, 1095-1111CrossRefGoogle ScholarPubMed
122Graf, J. et al. (1987) A pentapeptide from the laminin B1 chain mediates cell adhesion and binds the 67,000 laminin receptor. Biochemistry 26, 6896-6900CrossRefGoogle Scholar
123Jucker, M., Kleinman, H.K. and Ingram, D.K. (1991) Fetal rat septal cells adhere to and extend processes on basement membrane, laminin, and a synthetic peptide from the laminin A chain sequence. Journal of Neuroscience Research 28, 507-517CrossRefGoogle Scholar
124Ruoslahti, E. and Pierschbacher, M.D. (1986) Arg–Gly–Asp: a versatile cell recognition signal. Cell 44, 517-518CrossRefGoogle ScholarPubMed
125Smith Callahan, L.A. et al. (2013) Maximizing phenotype constraint and extracellular matrix production in primary human chondrocytes using arginine–glycine–aspartate concentration gradient hydrogels. Acta Biomaterialia 9, 7420-7428CrossRefGoogle ScholarPubMed
126Potter, W., Kalil, R.E. and Kao, W.J. (2008) Biomimetic material systems for neural progenitor cell-based therapy. Frontiers in Bioscience 13, 806-821CrossRefGoogle ScholarPubMed
127Zhang, Z.X. et al. (2010) Compatibility of neural stem cells with functionalized self-assembling peptide scaffold in vitro. Biotechnology and Bioengineering 15, 545-551Google Scholar
128Boontheekul, T. and Mooney, D.J. (2003) Protein-based signaling systems in tissue engineering. Current Opinion in Biotechnology 14, 559-565CrossRefGoogle ScholarPubMed
129Richardson, T.P. et al. (2001) Polymeric system for dual growth factor delivery. Nature Biotechnology 19, 1029-1034CrossRefGoogle ScholarPubMed
130Hosseinkhani, H., Kobayashi, H. and Tabata, Y. (2006) Selective differentiation of cardiomyocyte cells by using peptide amphiphile nanofibers. Peptide Science 2005, 63-66Google Scholar
131Hosseinkhani, H. et al. (2006) Enhanced angiogenesis through controlled release of basic fibroblast growth factor from peptide amphiphile for tissue regeneration. Biomaterials 27, 5836-5844CrossRefGoogle ScholarPubMed
132Gelain, F., Unsworth, L.D. and Zhang, S. (2010) Slow and sustained release of active cytokines from self-assembling peptide scaffolds. Journal of Controlled Release 145, 231-239CrossRefGoogle ScholarPubMed
133Hosseinkhani, H. et al. (2007) Bone regeneration through controlled release of bone morphogenetic protein-2 from 3-D tissue engineered nano-scaffold. Journal of Controlled Release 117, 380-386CrossRefGoogle ScholarPubMed
134Freeman, I., Kedem, A. and Cohen, S. (2008) The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins. Biomaterials 29, 3260-3268CrossRefGoogle ScholarPubMed
135Dvir, T. et al. (2009) Prevascularization of cardiac patch on the omentum improves its therapeutic outcome. Proceedings of the National Academy of Sciences of the United States of America 106, 14990-14995CrossRefGoogle ScholarPubMed
136Mujeeb, A. et al. (2013) Self-assembled octapeptide scaffolds for in vitro chondrocyte culture. Acta Biomaterialia 9, 4609-4617CrossRefGoogle ScholarPubMed
137Kopesky, P.W. et al. (2014) Sustained delivery of bioactive TGF-beta1 from self-assembling peptide hydrogels induces chondrogenesis of encapsulated bone marrow stromal cells. Journal of Biomedical Materials Research Part A 102, 1275-1285CrossRefGoogle ScholarPubMed
138Florine, E.M. et al. (2013) Effects of dexamethasone on mesenchymal stromal cell chondrogenesis and aggrecanase activity: comparison of agarose and self-assembling peptide scaffolds. Cartilage 4, 63-74CrossRefGoogle ScholarPubMed
139Kopesky, P.W. et al. (2010) Adult equine bone marrow stromal cells produce a cartilage-like ECM mechanically superior to animal-matched adult chondrocytes. Matrix Biology 29, 427-438CrossRefGoogle ScholarPubMed
140Erickson, I.E. et al. (2009) Differential maturation and structure-function relationships in mesenchymal stem cell- and chondrocyte-seeded hydrogels. Tissue Engineering Part A 15, 1041-1052CrossRefGoogle ScholarPubMed
141Ustun, S. et al. (2013) Growth and differentiation of prechondrogenic cells on bioactive self-assembled peptide nanofibers. Biomacromolecules 14, 17-26CrossRefGoogle ScholarPubMed
142Fernandez-Muinos, T. et al. (2014) Matrix dimensions, stiffness, and structural properties modulate spontaneous chondrogenic commitment of mouse embryonic fibroblasts. Tissue Engineering Part A 20, 1145-1155CrossRefGoogle ScholarPubMed
143Bussmann, B.M. et al. (2013) Chondrogenic potential of human dermal fibroblasts in a contractile, soft, self-assembling, peptide hydrogel. Journal of Tissue Engineering and Regenerative Medicine. Published online ahead of print, doi: 10.1002/term.1766Google Scholar
144Kisiday, J.D. et al. (2004) Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds. Journal of Biomechanics 37, 595-604CrossRefGoogle ScholarPubMed
145Maher, S.A. et al. (2010) A nanofibrous cell-seeded hydrogel promotes integration in a cartilage gap model. Journal of Tissue Engineering and Regenerative Medicine 4, 25-29Google Scholar
146Miller, R.E. et al. (2010) Effect of self-assembling peptide, chondrogenic factors, and bone marrow-derived stromal cells on osteochondral repair. Osteoarthritis Cartilage 18, 1608-1619CrossRefGoogle ScholarPubMed