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Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment

Published online by Cambridge University Press:  30 January 2015

Esak Lee ,
Niranjan B. Pandey  and
Aleksander S. Popel
Esak Lee
Affiliation:
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Niranjan B. Pandey
Affiliation:
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Aleksander S. Popel*
Affiliation:
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
*
*Corresponding author: Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 611 Traylor Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA. E-mail: [email protected]
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Abstract

Tumour and organ microenvironments are crucial for cancer progression and metastasis. Crosstalk between multiple non-malignant cell types in the microenvironments and cancer cells promotes tumour growth and metastasis. Blood and lymphatic endothelial cells (BEC and LEC) are two of the components in the microenvironments. Tumour blood vessels (BV), comprising BEC, serve as conduits for blood supply into the tumour, and are important for tumour growth as well as haematogenous tumour dissemination. Lymphatic vessels (LV), comprising LEC, which are relatively leaky compared with BV, are essential for lymphogenous tumour dissemination. In addition to describing the conventional roles of the BV and LV, we also discuss newly emerging roles of these endothelial cells: their crosstalk with cancer cells via molecules secreted by the BEC and LEC (also called angiocrine and lymphangiocrine factors). This review suggests that BEC and LEC in various microenvironments can be orchestrators of tumour progression and proposes new mechanism-based strategies to discover new therapies to supplement conventional anti-angiogenic and anti-lymphangiogenic therapies.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 17 , 2015 , e3
Copyright
Copyright © Cambridge University Press 2015 

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