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The complex metabolism of trimethylamine in humans: endogenous and exogenous sources

Published online by Cambridge University Press:  29 April 2016

Jyoti Chhibber-Goel ,
Anamika Gaur ,
Varsha Singhal ,
Neeraj Parakh ,
Balram Bhargava  and
Amit Sharma
Jyoti Chhibber-Goel
Affiliation:
Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
Anamika Gaur
Affiliation:
Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
Varsha Singhal
Affiliation:
Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
Neeraj Parakh
Affiliation:
Cardiothoracic Sciences Centre, All India Institute of Medical Sciences, New Delhi, India
Balram Bhargava
Affiliation:
Cardiothoracic Sciences Centre, All India Institute of Medical Sciences, New Delhi, India
Amit Sharma*
Affiliation:
Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
*
*Corresponding author: Amit Sharma, Group Leader, Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India. E-mail: [email protected]
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Abstract

Trimethylamine (TMA) is a tertiary amine with a characteristic fishy odour. It is synthesised from dietary constituents, including choline, L-carnitine, betaine and lecithin by the action of microbial enzymes during both healthy and diseased conditions in humans. Trimethylaminuria (TMAU) is a disease typified by its association with the characteristic fishy odour because of decreased TMA metabolism and excessive TMA excretion. Besides TMAU, a number of other diseases are associated with abnormal levels of TMA, including renal disorders, cancer, obesity, diabetes, cardiovascular diseases and neuropsychiatric disorders. Aside from its role in pathobiology, TMA is a precursor of trimethylamine-N-oxide that has been associated with an increased risk of athero-thrombogenesis. Additionally, TMA is a major air pollutant originating from vehicular exhaust, food waste and animal husbandry industry. The adverse effects of TMA need to be monitored given its ubiquitous presence in air and easy absorption through human skin. In this review, we highlight multifaceted attributes of TMA with an emphasis on its physiological, pathological and environmental impacts. We propose a clinical surveillance of human TMA levels that can fully assess its role as a potential marker of microbial dysbiosis-based diseases.

Type
Review
Information
Expert Reviews in Molecular Medicine , Volume 18 , 2016 , e8
Copyright
Copyright © Cambridge University Press 2016 

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References

1. National Institute for Occupational Safety and Health (NIOSH). (2015) Trimethylamine. Centre for Disease Control http://www.cdc.gov/niosh/npg/npgd0636.html Google Scholar
2. Burg, A.B. Sr. and Green, A.A. (1943) Addition compounds of trimethylamine with boron fluoride and its methyl derivatives. Journal of the American Chemical Society 65, 1838-1841 CrossRefGoogle Scholar
3. Wilson, H.C. (1964) On the origin of menstrual taboos. American Anthropologist 66, 622-625 CrossRefGoogle Scholar
4. Ashley-Montagu, M.F. (1938) Trimethylamine in menstruous women. Nature 142, 1121-1122 CrossRefGoogle Scholar
5. Wastl, H. (1942) Effects of trimethylamine on growth and sexual development in the rat. Journal of Physiology 101, 192-199 CrossRefGoogle ScholarPubMed
6. Wang, Z. et al. (2011) Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472, 57-63 CrossRefGoogle ScholarPubMed
7. Doree, C. and Golla, F. (1911) Trimethylamine as a normal constituent of human blood, urine and cerebrospinal fluid. Journal of Biochemistry 5, 306-324 Google Scholar
8. Cashman, J.R. (2002) Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism. Pharmacogenomics 3, 325-339 CrossRefGoogle ScholarPubMed
9. Rappert, S. and Muller, R. (2005) Odor compounds in waste gas emissions from agricultural operations and food industries. Waste Management 25, 887-907 CrossRefGoogle ScholarPubMed
10. Ho, K.L., Chung, Y.C. and Tseng, C.P. (2008) Continuous deodorization and bacterial community analysis of a biofilter treating nitrogen-containing gases from swine waste storage pits. Bioresource Technology 99, 2757-2765 CrossRefGoogle ScholarPubMed
11. Rehbein, P.J.G. et al. (2011) Cloud and fog processing enhanced gas-to-particle partitioning of trimethylamine. Environmental Science & Technology 45, 4346-4352 CrossRefGoogle ScholarPubMed
12. Diab, Y. et al. (2013) Characteristic analysis for odor gas emitted from food waste anaerobic fermentation in the pretreatment workshop. Journal of Air & Waste Management Association 63, 1173-81Google Scholar
13. Usunomena, U. et al. (2012) N-nitrosodimethylamine (NDMA), liver function enzymes, renal function parameters and oxidative stress parameters: a review. British Journal of Pharmacology and Toxicology 3, 165-176 Google Scholar
14. Zeisel, S.H., daCosta, K.A. and LaMont, J.T. (1988) Mono-, di- and trimethylamine in human gastric fluid: potential substrates for nitrosodimethylamine formation. Carcinogenesis 9, 179-181 Google Scholar
15. Koeth, R. et al. (2013) Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature Medicine 19, 576-85Google Scholar
16. Wang, Z. et al. (2015) Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis. Cell 163, 1585-1595 CrossRefGoogle ScholarPubMed
17. NCBI. (2015) Trimethylamine. Open chemistry database https://pubchem.ncbi.nlm.nih.gov/compound/1146#sec Google Scholar
18. Lee, M.B. et al. (2006) Validation of (1)H NMR spectroscopy as an analytical tool for methylamine metabolites in urine. Clinica Chemicha Acta 365, 264-269 Google Scholar
19. Mills, G.A., Walker, V. and Mughal, H. (1999) Quantitative determination of trimethylamine in urine by solid-phase microextraction and gas chromatography-mass spectrometry. Journal of Chromatography B, Biomedical Science and Application 723, 281-285 Google Scholar
20. daCosta, K.-A., Vrbanac, J.J. and Zeisel, S.H. (1990) The measurement of dimethylamine, trimethylamine, and trimethylamine N-oxide using capillary gas chromatography-mass spectrometry. Analytical Biochemistry 187, 234-239 Google Scholar
21. Johnson, D.W. (2008) A flow injection electrospray ionization tandem mass spectrometric method for the simultaneous measurement of trimethylamine and trimethylamine N-oxide in urine. Journal of Mass Spectrometry 43, 495-509 CrossRefGoogle ScholarPubMed
22. Mamer, O.A., Choinière, L. and Lesimple, A. (2010) Measurement of urinary trimethylamine and trimethylamine oxide by direct infusion electrospray quadrupole time-of-flight spectrometry. Analytical Biochemistry 406, 80-82 Google Scholar
23. Hsu, W.Y. et al. (2007) Rapid screening assay of trimethylaminuria in urine with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry 21, 1915-1919 Google Scholar
24. Pablos, J.L. et al. (2015) Solid polymer substrates and coated fibers containing 2,4,6-trinitrobenzene motifs as smart labels for the visual detection of biogenic amine vapors. Chemistry (Easton) 21, 8733-8736 Google Scholar
25. Lee, S.H. et al. (2015) Bioelectronic nose combined with a microfluidic system for the detection of gaseous trimethylamine. Biosensors and Bioelectronics 71, 179-185 CrossRefGoogle ScholarPubMed
26. Suska, A. et al. (2009) G protein-coupled receptor mediated trimethylamine sensing. Biosensors and Bioelectronics 25, 715-720 Google Scholar
27. Wallrabenstein, I. et al. (2013) Human trace Amine-Associated Receptor TAAR5 can be activated by Trimethylamine. PLoS ONE 8(2), e54950 CrossRefGoogle ScholarPubMed
28. Zhang, A.Q., Mitchell, S.C. and Smith, R.L. (1999) Dietary precursors of trimethylamine in man: a pilot study. Food and Chemical Toxicology 37, 515-520 CrossRefGoogle ScholarPubMed
29. Zhu, Y. et al. (2014) Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. Proceedings of the National Academy of Sciences of the United States of America 111, 4268-4273 Google Scholar
30. Craciun, S. and Balskus, E.P. (2012) Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme. Proceedings of the National Academy of Sciences of the United States of America 109, 21307-21312 CrossRefGoogle ScholarPubMed
31. Delgado, S. et al. (2006) Interindividual differences in microbial counts and biochemical-associated variables in the feces of healthy Spanish adults. Digestive Diseases and Sciences 51, 737-743 Google Scholar
32. Motika, M.S. et al. (2009) Novel variants of the human Flavin-containing Monooxygenase 3 (FMO3) gene associated with Trimethylaminuria. Molecular Genetics and Metabolism 97, 128-135 CrossRefGoogle ScholarPubMed
33. Chen, Y. et al. (2011) Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase. Proceedings of the National Academy of Sciences of the United States of America 108, 17791-17796 Google Scholar
34. Winter, S.E., Lopez, C.A. and Bäumler, A.J. (2013) The dynamics of gut-associated microbial communities during inflammation. EMBO Reports 14, 319-327 CrossRefGoogle ScholarPubMed
35. Balagam, B. and Richardson, D.E. (2008) The mechanism of carbon dioxide catalysis in the hydrogen peroxide N-oxidation of amines. Inorganic Chemistry 47, 1173-1178 CrossRefGoogle ScholarPubMed
36. Schöneich, C. (2005) Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease. Biochimica et Biophysica Acta – Proteins Proteomics 1703, 111-119 CrossRefGoogle ScholarPubMed
37. Kim, S.G., Bae, H.S. and Lee, S.T. (2001) A novel denitrifying bacterial isolate that degrades trimethylamine both aerobically and anaerobically via two different pathways. Archives of Microbiology 176, 271-277 Google Scholar
38. Colby, J. and Zatman, L.J. (1973) Trimethylamine metabolism in obligate and facultative methylotrophs. Biochemical Journal 132, 101-112 Google Scholar
39. Shi, W., Mersfelder, J. and Hille, R. (2005) The interaction of trimethylamine dehydrogenase and electron-transferring flavoprotein. Journal of Biological Chemistry 280, 20239-20246 CrossRefGoogle ScholarPubMed
40. Zhu, Y. et al. (2014) Identification and characterization of trimethylamine N-oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2. Environmental Microbiology 16, 3318-3330 Google Scholar
41. Sintermann, J., Schallhart, S. and Kajos, M. (2014) Trimethylamine emissions in animal husbandry. Biogeosciences 11, 5073-5085 Google Scholar
42. Silva, P.J. et al. (2008) Trimethylamine as precursor to secondary organic aerosol formation via nitrate radical reaction in the atmosphere. Environmental Science & Technology 42, 4689-4696 Google Scholar
43. Murphy, S.M. et al. (2007) Secondary aerosol formation from atmospheric reactions of aliphatic amines. Atmospheric Chemistry and Physics Discussion 7, 289-349 Google Scholar
44. Healy, R.M. et al. (2015) Single-particle speciation of alkylamines in ambient aerosol at five European sites. Analytical and Bioanalytical Chemistry 407, 5899-5909 CrossRefGoogle ScholarPubMed
45. Kenyon, S. et al. (2004) The passage of trimethylamine across rat and human skin. Food and Chemical Toxicology 42, 1619-1628 Google Scholar
46. Ongwandee, M., Bettinger, S.S. and Morrison, G.C. (2005) Influence of ammonia and carbon dioxide on the sorption of a basic organic pollutant to a mineral surface. Environmental Science & Technology 15, 408-419 Google ScholarPubMed
47. Ongwandee, M. and Morrison, G.C. (2008) Influence of ammonia and carbon dioxide on the sorption of a basic organic pollutant to carpet and latex-painted gypsum board. Environmental Science & Technology 42, 5415-5420 CrossRefGoogle ScholarPubMed
48. Amoore, J.E. and Forrester, L.J. (1976) Specific anosmia to trimethylamine: the fishy primary odour. Journal of Chemical Ecology 2, 49-56 CrossRefGoogle Scholar
49. Solbu, E.H., Jellestad, F.K. and Strætkvern, K.O. (1990) Children's sensitivity to odor of trimethylamine. Journal of Chemical Ecology 16, 1829-1840 Google Scholar
50. Humbert, J.R. et al. (1970) Trimethylaminuria: the fish-odour syndrome. Lancet 2, 770-771 Google Scholar
51. Wise, P.M. et al. (2011) Individuals reporting idiopathic malodor production: demographics and incidence of trimethylaminuria. American Journal of Medicine 124, 1058-1063 Google Scholar
52. Rehman, H. (1999) Fish odour syndrome. Postgraduate Medical Journal 75, 451-452 CrossRefGoogle Scholar
53. Bain, M.A. et al. (2006) Accumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis. Nephrology Dialysis Transplantation 21, 1300-1304 Google Scholar
54. Simenhoff, M.L. et al. (1978) Bacterial populations of the small intestine in uremia. Nephron 22, 63-68 Google Scholar
55. Hao, X. et al. (2013) Distinct metabolic profile of primary focal segmental glomerulosclerosis revealed by NMR-based metabolomics. PLoS ONE 8, 1-10 CrossRefGoogle ScholarPubMed
56. Tang, W.H. et al. (2015) Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circulation Research 116, 448-455 Google Scholar
57. Fayad, L.M. et al. (2014) Characterization of peripheral nerve sheath tumors with 3 T proton MR spectroscopy. American Journal of Neuroradiology 35, 1035-1041 CrossRefGoogle Scholar
58. Zira, A.N. et al. (2010) 1H NMR metabonomic analysis in renal cell carcinoma: a possible diagnostic tool. Journal of Proteome Research 9, 4038-4044 Google Scholar
59. Gao, H. et al. (2008) Metabonomic profiling of renal cell carcinoma: high-resolution proton nuclear magnetic resonance spectroscopy of human serum with multivariate data analysis. Analytica Chemica Acta 624, 269-277 CrossRefGoogle ScholarPubMed
60. Xia, K. et al. (2014) Discovery of systematic responses and potential biomarkers induced by ochratoxin A using metabolomics. Food Additives & Contaminants Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 31, 1904-1913 Google ScholarPubMed
61. Wang, L., Li, Y. and He, G. (2014) Degradation of typical N-nitrosodimethylamine (NDMA) precursors and its formation potential in anoxic-aerobic (AO) activated sludge system. Journal of Environmental Science and Health Part A Toxic/Hazardous Substances and Environmental Engineering 49, 1727-1739 Google ScholarPubMed
62. Pierson, M.D. and Smoot, L.A. (1982) Nitrite, nitrite alternatives, and the control of Clostridium botulinum in cured meats. Critical Reviews in Food Science and Nutrition 17, 141-187 CrossRefGoogle ScholarPubMed
63. Guengerich, F.P., Kim, D.H. and Iwasaki, M. (1991) Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chemical Research in Toxicology 4, 168-179 CrossRefGoogle ScholarPubMed
64. Schönthal, A.H. (2012) Endoplasmic reticulum stress: its role in disease and novel prospects for therapy. Scientifica (Cairo) . 2012, 857516 Google ScholarPubMed
65. Cnop, M., Foufelle, F. and Velloso, L.A. (2012) Endoplasmic reticulum stress, obesity and diabetes. Trends in Molecular Medicine 18, 59-68 Google Scholar
66. Miao, J. et al. (2015) Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis. Nature Communications 6, 6498 CrossRefGoogle ScholarPubMed
67. Pitsavos, C. et al. (2006) Diet, exercise and the metabolic syndrome. Review of Diabetic Studies 3, 118-126 CrossRefGoogle ScholarPubMed
68. Quigley, E.M.M. (2013) Gut bacteria in health and disease. Gastroenterology and Hepatology 9, 560-569 Google ScholarPubMed
69. Swidsinski, A. et al. (2005) Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease. Journal of Clinical Microbiology 43, 3380-3389 Google Scholar
70. Murdoch, T.B. et al. (2008) Urinary metabolic profiles of inflammatory bowel disease in interleukin-10 gene-deficient mice. Analytical Chemistry 80, 5524-5531 Google Scholar
71. Srinivasa, S. et al. (2015) Plaque burden in HIV-infected patients is associated with serum intestinal microbiota-generated trimethylamine. AIDS 29, 443-452 Google Scholar
72. Shariff, M.I.F. et al. (2011) Urinary metabolic biomarkers of hepatocellular carcinoma in an Egyptian population: a validation study. Journal of Proteome Research 10, 1828-1836 Google Scholar
73. Alkhouri, N. et al. (2014) Analysis of breath volatile organic compounds as a noninvasive tool to diagnose nonalcoholic fatty liver disease in children. European Journal of Gastroenterology and Hepatology 26, 82-87 Google Scholar
74. Hanouneh, I.A. et al. (2014) The breathprints in patients with liver disease identify novel breath biomarkers in alcoholic hepatitis. Clinical Gastroenterology and Hepatology 12, 516-523 CrossRefGoogle ScholarPubMed
75. George, J. et al. (2001) Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen. Toxicology 156, 129-138 Google Scholar
76. Hecht, S.S. (1997) Approaches to cancer prevention based on an understanding of N-nitrosamine carcinogenesis. Proceedings of the Society for Experimental Biology and Medicine 216, 181-191 CrossRefGoogle Scholar
77. Pellicciari, A. et al. (2011) Epilepsy and trimethylaminuria: a new case report and literature review. Brain & Development 33, 593-596 Google Scholar
78. McConnell, H.W. et al. (1997) Trimethylaminuria associated with seizures and behavioural disturbance: a case report. Seizure 6, 317-321 Google Scholar
79. Chang, W.P., Wu, J.J.S. and Shyu, B.C. (2013) Thalamic modulation of cingulate Seizure activity via the regulation of gap junctions in mice Thalamocingulate slice. PLoS ONE 8(5), e62952 Google ScholarPubMed
80. Bocian, R. et al. (2011) Gap junction modulation of hippocampal formation theta and local cell discharges in anesthetized rats. European Journal of Neuroscience 33, 471-481 CrossRefGoogle ScholarPubMed
81. Luo, Y., Zhu, J. and Gao, Y. (2012) Metabolomic analysis of the plasma of patients with high-altitude pulmonary edema (HAPE) using 1H NMR. Molecular Biosystems 8, 1783-1788 CrossRefGoogle Scholar
82. Paul, S. et al. (2015) High altitude pulmonary edema: an update on Omics data and redefining susceptibility. Proteomics and Bioinformatics 8, 116-125 Google Scholar
83. Maitre, L. et al. (2014) Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother-child cohort study. BioMed Central Medicine 12, 110 Google ScholarPubMed
84. Koren, O. et al. (2012) Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell 150, 470-480 CrossRefGoogle ScholarPubMed
85. Di Cianni, G. et al. (2003) Intermediate metabolism in normal pregnancy and in gestational diabetes. Diabetes/Metabolism Research Reviews 19, 259-270 CrossRefGoogle ScholarPubMed
86. Lain, K.Y. and Catalano, P.M. (2007) Metabolic changes in pregnancy. Clinical Obstetrics and Gynecology 50, 938-948 Google Scholar
87. Scott, M., Nelson, P.M. and Poston, L. (2010) Maternal metabolism and obesity: Modifiable determinants of pregnancy outcome. Human Reproduction Update 16, 255-275 Google Scholar
88. Wang, Z. et al. (2014) Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry. Analytical Biochemistry 455, 35-40 Google Scholar
89. Mark Brown, J. and Hazen, S.L. (2014) Meta-organismal nutrient metabolism as a basis of cardiovascular disease. Current Opinion in Lipidology 25, 48-53 Google Scholar
90. Lewis, G.D. et al. (2008) Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. Journal of Clinical Investigation 118, 3503-3512 CrossRefGoogle ScholarPubMed
91. Hartiala, J. et al. (2014) Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine. Arteriosclerosis Thrombosis and Vascular Biology 34, 1307-1313 Google Scholar
92. Tang, W.H. et al. (2015) Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure. Journal of Cardiac Failure 21, 91-96 Google Scholar
93. Kaysen, G.A. et al. (2015) Associations of trimethylamine N-oxide with nutritional and inflammatory biomarkers and cardiovascular outcomes in patients new to dialysis. Journal of Renal Nutrition 25(4), 351-6Google Scholar
94. Rasmussen, L.G. et al. (2012) Assessment of the effect of high or low protein diet on the human urine metabolome as measured by NMR. Nutrients 4, 112-131 Google Scholar
95. Lloyd, A.J. et al. (2011) Use of mass spectrometry fingerprinting to identify urinary metabolites after consumption of specific foods. American Journal of Clinical Nutrition 94, 981-991 CrossRefGoogle ScholarPubMed
96. Mondul, A.M. et al. (2015) Metabolomic analysis of prostate cancer risk in a prospective cohort: the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. International Journal of Cancer 137(9), 1-26 Google Scholar
97. Bag, S. et al. (2015) NMR (1H and 13C) based signatures of abnormal choline metabolism in oral squamous cell carcinoma with no prominent Warburg effect. Biochemical Biophysical Research Communications 459, 574-578 Google Scholar
98. Bae, S. et al. (2014) Plasma choline metabolites and colorectal cancer risk in the Women's Health Initiative Observational Study. Cancer Research 74, 7442-7452 Google Scholar
99. Klepacki, J. et al. (2015) A high-performance liquid chromatography - tandem mass spectrometry – based targeted metabolomics kidney dysfunction marker panel in human urine. Clinica Chimica Acta 446, 43-53 Google Scholar
100. Somashekar, B.S. et al. (2011) Metabolic profiling of lung granuloma in Mycobacterium tuberculosis infected guinea pigs: ex vivo 1H magic angle spinning NMR studies. Journal of Proteome Research 2, 4186-4195 Google Scholar
101. Boraphech, P. and Thiravetyan, P. (2015) Trimethylamine (fishy odor) adsorption by biomaterials: effect of fatty acids, alkanes, and aromatic compounds in waxes. Journal of Hazardous Materials 284, 269-277 Google Scholar
102. Boraphech, P. and Thiravetyan, P. (2015) Removal of trimethylamine (fishy odor) by C3 and CAM plants. Environmental Science and Pollution Research 22, 11543-11557 Google Scholar
103. Vieira, S.M. and Pagovich, O.E. (2014) Diet, microbiota and autoimmune diseases. Lupus 23, 518-526 CrossRefGoogle ScholarPubMed
104. Zarrinpar, A. et al. (2014) Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. Cell Metabolism 20, 1006-1017 Google Scholar
105. Glick-Bauer, M. and Yeh, M.-C. (2014) The health advantage of a vegan diet: exploring the gut microbiota connection. Nutrients 6, 4822-4838 Google Scholar
106. Chang, C.T. et al. (2004) Biofiltration of trimethylamine-containing waste gas by entrapped mixed microbial cells. Chemosphere 55, 751-756 CrossRefGoogle ScholarPubMed
107. Ho, K.L. et al. (2008) Biofiltration of trimethylamine, dimethylamine, and methylamine by immobilized Paracoccus sp. CP2 and Arthrobacter sp. CP1. Chemosphere 72, 250-256 Google Scholar
108. Smits, L.P. et al. (2013) Therapeutic potential of fecal microbiota transplantation. Gastroenterology 145, 946-953 CrossRefGoogle ScholarPubMed
109. Wilson Tang, W.H. et al. (2013) Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. New England Journal of Medicine 368, 1575-1584 Google Scholar
110. Lidbury, Ian DEA, Murrell, J.C. and Chen, Y. (2015) Trimethylamine and trimethylamine N-oxide are supplementary energy sources for a marine heterotrophic bacterium: implications for marine carbon and nitrogen cycling. International Society for Microbial Ecology 9, 760-769 Google ScholarPubMed
111. Dridi, B. et al. (2012) Methanomassiliicoccus luminyensis gen. nov., sp. nov., a methanogenic archaeon isolated from human faeces. International Journal of Systematic and Evolutionary Microbiology 62, 1902-1907 Google Scholar
112. Brugère, J.F., et al. (2014) Archaebiotics: proposed therapeutic use of archaea to prevent trimethylaminuria and cardiovascular disease. Gut Microbes 5, 5-10 Google Scholar
113. Ozasa, H. et al. (2014) Trimethylamine generation in patients receiving hemodialysis treated with L-carnitine. Clinical Kidney Journal 7, 329-329 CrossRefGoogle ScholarPubMed
114. Endre, Z.H. et al. (2011) Breath ammonia and trimethylamine allow real-time monitoring of haemodialysis efficacy. Physiological Measurement 32, 115-130 CrossRefGoogle ScholarPubMed
115. Zhou, X.M. et al. (2012) Metabonomic classification and detection of small molecule biomarkers of malignant pleural effusions. Analytical and Bioanalytical Chemistry 404, 3123-3133 CrossRefGoogle ScholarPubMed
116. Mirvish, S.S. (1995) Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC. Cancer Letters 93, 17-48 Google Scholar
117. Craciun, S.L., Marks, J.A. and Balskus, E.P. (2014) Characterization of choline trimethylamine-lyase expands the chemistry of glycyl radical enzymes. ASC Chemical Biology 18, 1408-1413 Google Scholar
118. Romano, K.A. et al. (2015) Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide. mBio 6, e02481-e02414 Google Scholar